HitPredict

Interactor 1: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	30587576, 31253590, 36423380, 21145461, 31950832
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 334 Hs			1 780
+	Hs
		1042204 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1041128 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		CUL1_HUMAN (11-780): 0: 748: 27.84
+	Hs
		1043142 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1043493 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	At
		1227343 CSN5A_ARATH (1-334): 5.43e-121: 354: 65.69		CUL3A_ARATH (16-780): 0: 759: 23.18
+	Hs
		1041423 CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00		CUL2_HUMAN (6-780): 0: 699: 26.36
+	At
		1228142 CSN5B_ARATH (1-334): 8.46e-119: 348: 66.57		CUL4_ARATH (16-780): 0: 694: 24.09
+	Ce
		954204 CSN5_CAEEL (5-329): 4.44e-108: 321: 56.88		CUL3_CAEEL (17-780): 0: 658: 21.47
+	Hs
		849195 PSMD7_HUMAN (52-325): 1.07e-66: 214: 14.79		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		124855 EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		177020 EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Sp
		142913 CSN5_SCHPO (23-279): 5.4e-81: 250: 43.35		CUL1_SCHPO (3-780): 0: 680: 24.97
+	Hs
		805526 BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Sp
		293444 CSN5_SCHPO (23-279): 5.4e-81: 250: 43.35		CUL3_SCHPO (9-780): 0: 612: 20.78
+	Sc
		1014851 CSN5_YEAST (22-299): 9.32e-57: 191: 29.51		CDC53_YEAST (6-780): 0: 600: 21.43