HitPredict

Interactor 1: BMI1B (Q7T3E6)
Polycomb complex protein BMI-1-B (Polycomb group RING finger protein 4-B)
Gene: BMI1B

Interactor 2: Q804D1 (Q804D1)
E3 SUMO-protein ligase CBX4 (Polycomb 2)
Gene: cbx4

Species: Danio rerio

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21195142
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0035102 - PRC1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 324 Dr			1 477
+	Dr
		1281817 BMI1A_DANRE (1-322): 1.67e-92: 279: 74.30		Q804D1_DANRE (1-477): 7.01e-130: 386: 100.00
+	Hs
		129671 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX4_HUMAN (1-475): 9.92e-100: 312: 40.57
+	Hs
		129672 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX4_HUMAN (1-475): 9.92e-100: 312: 40.57
+	Mm
		237300 PCGF2_MOUSE (1-320): 1.24e-83: 258: 59.41		CBX4_MOUSE (1-475): 2.24e-102: 318: 40.51
+	Mm
		683118 BMI1_MOUSE (1-322): 1.06e-98: 295: 76.85		CBX2_MOUSE (2-473): 1.52e-68: 229: 20.08
+	Hs
		765521 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX2_HUMAN (2-473): 1.21e-66: 225: 20.45
+	Mm
		683133 BMI1_MOUSE (1-322): 1.06e-98: 295: 76.85		CBX8_MOUSE (1-394): 9.4e-63: 210: 21.14
+	Hs
		765905 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX8_HUMAN (1-394): 2.95e-59: 201: 19.37
+	Hs
		766090 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX2_HUMAN (2-473): 1.21e-66: 225: 20.45
+	Hs
		338780 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX6_HUMAN (1-393): 2.94e-55: 191: 19.80
+	Mm
		662900 PCGF2_MOUSE (1-320): 1.24e-83: 258: 59.41		CBX2_MOUSE (2-473): 1.52e-68: 229: 20.08
+	Hs
		766124 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX8_HUMAN (1-394): 2.95e-59: 201: 19.37
+	Hs
		338781 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX6_HUMAN (1-393): 2.94e-55: 191: 19.80
+	Hs
		765823 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		MPP8_HUMAN (6-340): 1.14e-38: 151: 14.94
+	Hs
		351372 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX7_HUMAN (1-230): 1.55e-40: 147: 29.63
+	Hs
		351373 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX7_HUMAN (1-230): 1.55e-40: 147: 29.63
+	Hs
		765219 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX5_HUMAN (11-123): 6.19e-24: 100: 25.66
+	Hs
		765466 BMI1_HUMAN (1-322): 1.69e-99: 298: 76.62		CBX3_HUMAN (9-72): 2.54e-22: 96: 39.06
+	Mm
		662909 PCGF2_MOUSE (1-320): 1.24e-83: 258: 59.41		CBX7_MOUSE (1-127): 6.64e-32: 121: 48.03
+	Hs
		766087 PCGF2_HUMAN (1-320): 2.39e-89: 272: 60.29		CBX3_HUMAN (9-72): 2.54e-22: 96: 39.06