Protein: PCGF2
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)

Gene: PCGF2
Organism: Homo sapiens
Interactions: 93
UniProt ID: P35227

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001701 - in utero embryonic development
GO:0001739 - sex chromatin
GO:0003677 - DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

766113

RING2
E3 ubiquitin-protein ligase RING2

17

19

Small-scale

0.988

High

766085

RING1
E3 ubiquitin-protein ligase RING1

13

19

Small-scale

0.983

High

766124

CBX8
Chromobox protein homolog 8

11

20

Small-scale

0.981

High

766090

CBX2
Chromobox protein homolog 2

10

20

Small-scale

0.974

High

129672

CBX4
E3 SUMO-protein ligase CBX4

10

20

Small-scale

0.972

High

766103

RYBP
RING1 and YY1-binding protein

7

20

High-throughput

0.965

High

766102

YAF2
YY1-associated factor 2

7

20

Small-scale

0.960

High

351373

CBX7
Chromobox protein homolog 7

6

20

Small-scale

0.957

High

338781

CBX6
Chromobox protein homolog 6

6

20

High-throughput

0.947

High

765179

BMI1
Polycomb complex protein BMI-1

4

20

Small-scale

0.892

High

766096

BCORL
BCL-6 corepressor-like protein 1

3

19

High-throughput

0.861

High

766079

UBC9
SUMO-conjugating enzyme UBC9

3

20

Small-scale

0.857

High

766068

PCGF2
Polycomb group RING finger protein 2

2

19

Small-scale

0.768

High

766082

PHC1
Polyhomeotic-like protein 1

12

20

Small-scale

0.759

High

766101

PHC2
Polyhomeotic-like protein 2

11

20

Small-scale

0.759

High

766098

BCOR
BCL-6 corepressor

2

20

High-throughput

0.754

High

766105

PHC3
Polyhomeotic-like protein 3

8

20

Small-scale

0.749

High

766111

SCMH1
Polycomb protein SCMH1

4

20

High-throughput

0.699

High

766112

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.698

High

766127

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

20

High-throughput

0.698

High

507599

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.691

High

766093

H2B2E
Histone H2B type 2-E

1

18

High-throughput

0.691

High

766107

UB2Q2
Ubiquitin-conjugating enzyme E2 Q2

1

0

High-throughput

0.663

High

766076

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

Small-scale

0.647

High

728061

AKT1
RAC-alpha serine/threonine-protein kinase

2

3

Small-scale

0.629

High

766110

LTV1
Protein LTV1 homolog

2

1

High-throughput

0.628

High

766097

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

766094

PCGF3
Polycomb group RING finger protein 3

1

19

High-throughput

0.618

High

766099

PCGF5
Polycomb group RING finger protein 5

1

19

High-throughput

0.618

High

766115

PCGF1
Polycomb group RING finger protein 1

1

19

High-throughput

0.618

High

766117

PCGF6
Polycomb group RING finger protein 6

1

19

High-throughput

0.618

High

766133

SCML1
Sex comb on midleg-like protein 1

2

20

High-throughput

0.611

High

766086

TRAF2
TNF receptor-associated factor 2

2

19

High-throughput

0.606

High

766119

KLH25
Kelch-like protein 25

3

1

High-throughput

0.604

High

766126

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

9

High-throughput

0.604

High

766089

NUCG
Endonuclease G, mitochondrial

2

0

High-throughput

0.602

High

766074

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

15

Small-scale

0.597

High

766108

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

18

Small-scale

0.597

High

718767

CCND2
G1/S-specific cyclin-D2

1

3

Small-scale

0.589

High

282680

E2F6
Transcription factor E2F6

2

15

Small-scale

0.584

High

766084

HSF2
Heat shock factor protein 2

1

2

Small-scale

0.573

High

746182

STX2
Syntaxin-2

2

1

High-throughput

0.553

High

385502

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

19

Small-scale

0.552

High

331502

SPDEF
SAM pointed domain-containing Ets transcription factor

1

12

High-throughput

0.541

High

725128

HXC9
Homeobox protein Hox-C9

1

4

High-throughput

0.541

High

766075

SUMO3
Small ubiquitin-related modifier 3

1

4

High-throughput

0.541

High

766118

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

3

High-throughput

0.541

High

766092

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.536

High

766114

TBA1C
Tubulin alpha-1C chain

1

16

High-throughput

0.536

High

766125

MOV10
Helicase MOV-10

1

7

Small-scale

0.536

High

766128

LANC2
LanC-like protein 2

1

2

High-throughput

0.536

High

766131

FBLN5
Fibulin-5

1

3

High-throughput

0.536

High

766134

NFS1
Cysteine desulfurase

1

1

High-throughput

0.536

High

766069

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.513

High

185473

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

8

High-throughput

0.501

High

335233

CXB5
Gap junction beta-5 protein

1

1

High-throughput

0.494

High

766116

ABHD6
Monoacylglycerol lipase ABHD6

1

1

High-throughput

0.494

High

299082

FLOT1
Flotillin-1

1

4

High-throughput

0.489

High

464122

TPM2
Tropomyosin beta chain

1

7

High-throughput

0.489

High

766072

GBG10

1

1

High-throughput

0.489

High

766088

MSLN
Mesothelin

1

1

High-throughput

0.489

High

766104

KCD17
BTB/POZ domain-containing protein KCTD17

1

5

High-throughput

0.489

High

667585

CDK2
Cyclin-dependent kinase 2

1

9

Small-scale

0.481

High

259528

BRD4
Bromodomain-containing protein 4

1

13

High-throughput

0.479

High

285107

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

487012

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

625220

CSK22
Casein kinase II subunit alpha'

1

20

High-throughput

0.479

High

634326

LMNB1
Lamin-B1

1

20

Small-scale

0.479

High

675385

TYY1
Transcriptional repressor protein YY1

1

20

Small-scale

0.479

High

766070

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

Small-scale

0.479

High

766071

RAGP1
Ran GTPase-activating protein 1

1

5

Small-scale

0.479

High

766073

EMD
Emerin

1

2

Small-scale

0.479

High

766077

DCAF7
DDB1- and CUL4-associated factor 7

1

20

High-throughput

0.479

High

766078

SKP1
S-phase kinase-associated protein 1

1

10

High-throughput

0.479

High

766080

CSK2B
Casein kinase II subunit beta

1

9

High-throughput

0.479

High

766081

CSK21
Casein kinase II subunit alpha

1

20

High-throughput

0.479

High

766083

HSF1
Heat shock factor protein 1

1

2

Small-scale

0.479

High

766087

CBX3
Chromobox protein homolog 3

1

20

High-throughput

0.479

High

766091

PCBP1
Poly(rC)-binding protein 1

1

15

Small-scale

0.479

High

766100

MGAP
MAX gene-associated protein

1

12

High-throughput

0.479

High

766106

KDM2B
Lysine-specific demethylase 2B

1

20

High-throughput

0.479

High

766109

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

20

High-throughput

0.479

High

766121

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

766132

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

766095

DCAF6
DDB1- and CUL4-associated factor 6

1

15

High-throughput

0.445

High

376586

EGF
Pro-epidermal growth factor

1

3

Small-scale

0.437

High

766122

FBRS
Probable fibrosin-1

1

20

High-throughput

0.437

High

766129

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

2

0

High-throughput

0.328

High

766123

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

0

High-throughput

0.316

High

635825

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.282

High

766130

CTNL1
Alpha-catulin

1

0

High-throughput

0.282

High

766120

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025