HitPredict

Interactor 1: TICRR (Q7Z2Z1)
Treslin (TopBP1-interacting checkpoint and replication regulator) (TopBP1-interacting, replication-stimulating protein)
Gene: TICRR

Interactor 2: TOPB1 (Q92547)
DNA topoisomerase 2-binding protein 1 (DNA topoisomerase II-beta-binding protein 1) (TopBP1) (DNA topoisomerase II-binding protein 1)
Gene: TOPBP1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 0.60 0.747

The method score is based on:

Property Details
Experiments 23696651, 28439015, 23704573, 30295604, 30695077, 33503405, 21700459
Identification Methods affinity chromatography technology, pull down, proximity labelling technology, two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0007095 - mitotic G2 DNA damage checkpoint signaling
GO:0010212 - response to ionizing radiation
and 1 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 1910
Hs

1 1522
+ Xl
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm

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Last updated: 11Aug2025