HitPredict

Interactor 1: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Interactor 2: Q9VNF6 (Q9VNF6)
Metastasis associated 1-like, isoform A
Gene: MTA1-like

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25294943
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl, Hist_deacetyl~Myb_DNA-binding
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003714 - transcription corepressor activity GO:0005654 - nucleoplasm GO:0016581 - NuRD complex and 1 others more... GO:0030261 - chromosome condensation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 521 Dm			1 880
+	Dm
		81423 HDAC1_DROME (1-521): 0: 674: 100.00		B7Z0T5_DROME (10-880): 0: 716: 95.75
+	Hs
		1270490 HDAC2_HUMAN (2-488): 0: 659: 76.59		RERE_HUMAN (168-875): 1.71e-82: 292: 19.73
+	Hs
		1270488 HDAC2_HUMAN (2-488): 0: 659: 76.59		RCOR3_HUMAN (232-762): 2.92e-73: 250: 15.64
+	Dm
		1196991 HDAC1_DROME (1-521): 0: 674: 100.00		Q86BH2_DROME (226-770): 4.78e-61: 228: 17.13
+	Dm
		1276528 HDAC1_DROME (1-521): 0: 674: 100.00		Q9NHX6_DROME (226-770): 3.91e-60: 225: 17.13
+	Hs
		1270515 HDAC2_HUMAN (2-488): 0: 659: 76.59		RCOR1_HUMAN (230-656): 2.3e-64: 226: 13.53
+	Hs
		1223936 HDAC2_HUMAN (2-488): 0: 659: 76.59		RCOR2_HUMAN (218-750): 1e-63: 225: 14.86
+	Mm
		936416 HDAC2_MOUSE (2-488): 0: 655: 76.18		RCOR2_MOUSE (218-750): 4.13e-63: 223: 14.50
+	Mm
		936418 HDAC2_MOUSE (2-488): 0: 655: 76.18		RCOR1_MOUSE (230-653): 1.45e-63: 223: 14.09
+	Hs
		1189328 HDAC2_HUMAN (2-488): 0: 659: 76.59		MIER3_HUMAN (217-583): 4.26e-61: 218: 17.16
+	Hs
		1162162 HDAC2_HUMAN (2-488): 0: 659: 76.59		MDEAS_HUMAN (224-556): 2.38e-55: 209: 13.15
+	Hs
		1231960 HDAC2_HUMAN (2-488): 0: 659: 76.59		MIER2_HUMAN (207-580): 1.62e-53: 197: 16.71
+	Dm
		1123842 HDAC1_DROME (1-521): 0: 674: 100.00		RCOR_DROME (229-757): 2.26e-47: 180: 14.50
+	Hs
		1229946 HDAC2_HUMAN (2-488): 0: 659: 76.59		MIER1_HUMAN (224-578): 1.04e-48: 182: 19.34
+	Dm
		51892 HDAC1_DROME (1-521): 0: 674: 100.00		A1Z6Z7_DROME (225-403): 1.29e-42: 166: 23.42
+	Hs
		1270415 HDAC2_HUMAN (2-488): 0: 659: 76.59		MTA3_HUMAN (1-79): 1.06e-32: 136: 62.03
+	Hs
		1031919 HDAC2_HUMAN (2-488): 0: 659: 76.59		MTA1_HUMAN (1-63): 1.52e-27: 121: 71.43
+	Hs
		296092 HDAC2_HUMAN (2-488): 0: 659: 76.59		MTA2_HUMAN (1-73): 2.19e-27: 120: 57.53
+	Mm
		936419 HDAC2_MOUSE (2-488): 0: 655: 76.18		MTA1_MOUSE (1-63): 6.02e-27: 119: 71.43
+	Hs
		1270546 HDAC2_HUMAN (2-488): 0: 659: 76.59		NCOR2_HUMAN (329-874): 2.3e-13: 76.7: 11.22