HitPredict

Interactor 1: ARHGQ (Q96DR7)
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)
Gene: ARHGEF26

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.50	0.633

Property	Details
Experiments	32203420, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 871 Hs			1 197
+	Hs
		1288532 ARHGQ_HUMAN (1-871): 0: 549: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		159251 ARHGQ_HUMAN (1-871): 0: 549: 100.00		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		1021546 ARHGQ_HUMAN (1-871): 0: 549: 100.00		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		1271019 ARHGQ_HUMAN (1-871): 0: 549: 100.00		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Mm
		88351 D3YYY8_MOUSE (1-871): 2.93e-176: 533: 86.27		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		1138663 ARHGG_HUMAN (179-871): 7.61e-106: 344: 41.30		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1033880 ARHGG_HUMAN (179-871): 7.61e-106: 344: 41.30		SNTB2_HUMAN (61-179): 3e-32: 123: 35.25
+	Hs
		548755 VAV_HUMAN (376-806): 2.68e-78: 273: 16.20		LIN7C_HUMAN (1-197): 1.38e-57: 181: 100.00
+	Hs
		1021513 ARHGG_HUMAN (179-871): 7.61e-106: 344: 41.30		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		1138654 ARHGG_HUMAN (179-871): 7.61e-106: 344: 41.30		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02
+	Mm
		57002 OBSCN_MOUSE (27-858): 3.08e-80: 286: 12.82		A2AKD7_MOUSE (40-184): 1.21e-30: 118: 26.71
+	Hs
		942359 ARHG8_HUMAN (386-796): 4.49e-83: 280: 17.90		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		1021522 ARHG8_HUMAN (386-796): 4.49e-83: 280: 17.90		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		1191348 ARHG8_HUMAN (386-796): 4.49e-83: 280: 17.90		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Hs
		1191350 ARHG8_HUMAN (386-796): 4.49e-83: 280: 17.90		SNX27_HUMAN (91-175): 2.59e-12: 66.6: 38.14
+	Hs
		1191351 ARHG8_HUMAN (386-796): 4.49e-83: 280: 17.90		MAGI1_HUMAN (94-172): 5.41e-10: 60.1: 35.44
+	Mm
		57873 KALRN_MOUSE (431-866): 1.08e-62: 233: 15.19		DLG2_MOUSE (23-196): 1.12e-25: 105: 23.63
+	Mm
		1164175 ARHG8_MOUSE (269-848): 4.01e-80: 272: 15.66		MAGI1_MOUSE (94-172): 1.82e-10: 61.2: 36.71
+	Mm
		57852 KALRN_MOUSE (431-866): 1.08e-62: 233: 15.19		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		224721 KALRN_HUMAN (424-866): 8.06e-63: 233: 14.51		LNX1_HUMAN (14-179): 1.21e-17: 82.1: 22.02