Protein: HEL2
E3 ubiquitin-protein ligase HEL2 (EC 2.3.2.27) (Histone E3 ligase 2) (RING-type E3 ubiquitin transferase HEL2)

Gene: HEL2
Organism: Saccharomyces cerevisiae S288C
Interactions: 52
UniProt ID: Q05580

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding
GO:0010629 - negative regulation of gene expression
GO:0016567 - protein ubiquitination
GO:0022626 - cytosolic ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585729

UBC4
Ubiquitin-conjugating enzyme E2 4

5

3

Small-scale

0.718

High

435363

RS3
Small ribosomal subunit protein uS3

4

1

Small-scale

0.683

High

802387

RS20
Small ribosomal subunit protein uS10

3

1

Small-scale

0.667

High

919666

ASCC3
RQC trigger complex helicase SLH1

2

2

Small-scale

0.601

High

792248

GBLP
Small ribosomal subunit protein RACK1

2

5

Small-scale

0.586

High

646537

RAD53
Serine/threonine-protein kinase RAD53

2

0

Small-scale

0.569

High

689663

RS7A
Small ribosomal subunit protein eS7A

2

1

Small-scale

0.543

High

1043595

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.536

High

382349

H4
Histone H4

1

1

Small-scale

0.512

High

587335

ABP1
Actin-binding protein

1

1

High-throughput

0.501

High

599405

FUS3
Mitogen-activated protein kinase FUS3

1

0

High-throughput

0.480

High

656878

KC12
Casein kinase I homolog 2

1

0

High-throughput

0.480

High

801925

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.480

High

518129

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.479

High

531404

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

645536

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.479

High

836897

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.479

High

514838

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

680068

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

708191

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

781608

RQT4
RQC trigger complex subunit RQT4

1

0

Small-scale

0.458

High

806500

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

807924

BFR1
Nuclear segregation protein BFR1

1

0

High-throughput

0.458

High

817290

ARB1
ABC transporter ATP-binding protein ARB1

1

0

High-throughput

0.458

High

824947

TM108
Protein TMA108

1

0

High-throughput

0.458

High

917594

CUE3
RQC trigger complex subunit CUE3

1

0

Small-scale

0.458

High

1051639

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1051641

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1051642

HAA1
Transcriptional activator HAA1

1

0

High-throughput

0.458

High

735561

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.457

High

870683

RS7B
Small ribosomal subunit protein eS7B

1

1

Small-scale

0.457

High

393334

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

510822

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.445

High

525159

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

527683

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

546281

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

819799

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

925055

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

1051640

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

824552

6P21
6-phosphofructo-2-kinase 1

1

0

High-throughput

0.426

High

1051637

HEL2
E3 ubiquitin-protein ligase HEL2

1

1

Small-scale

0.408

High

800363

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.279

Low

1051638

YP114
Uncharacterized TLC domain-containing protein YPR114W

1

0

High-throughput

0.269

Low

823449

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

455265

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

513221

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

694643

SPT5
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

826838

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

963720

H3
Histone H3

1

0

Small-scale

0.249

Low

1044749

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

924733

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025