HitPredict

Interactor 1: CYFP2 (Q96F07)
Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)
Gene: CYFIP2

Interactor 2: WASF3 (Q9UPY6)
Actin-binding protein WASF3 (Protein WAVE-3) (Verprolin homology domain-containing protein 3) (Wiskott-Aldrich syndrome protein family member 3) (WASP family protein member 3)
Gene: WASF3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	FragX_IP~WH2
Common GO terms	GO:0031209 - SCAR complex GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1278 Hs			1 502
+	Hs
		1267028 CYFP2_HUMAN (1-1278): 0: 2164: 100.00		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		1290821 CYFP2_HUMAN (1-1278): 0: 2164: 100.00		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Mm
		1131096 CYFP2_MOUSE (1-1278): 0: 2126: 97.97		WASF2_MOUSE (1-484): 9.89e-66: 222: 42.56
+	Mm
		1131134 CYFP2_MOUSE (1-1278): 0: 2126: 97.97		WASF1_MOUSE (1-500): 1.12e-58: 204: 43.21
+	Bt
		94414 F1MX60_BOVIN (1-1278): 0: 2120: 97.81		WASF1_BOVIN (1-500): 9.32e-59: 205: 43.93
+	Hs
		1184673 CYFP1_HUMAN (1-1277): 0: 2040: 85.92		WASF3_HUMAN (1-502): 1.19e-73: 243: 100.00
+	Hs
		1184637 CYFP1_HUMAN (1-1277): 0: 2040: 85.92		WASF1_HUMAN (1-500): 3.42e-59: 206: 43.57
+	Hs
		1184678 CYFP1_HUMAN (1-1277): 0: 2040: 85.92		WASF2_HUMAN (1-484): 2.01e-57: 200: 43.60
+	Mm
		1186404 CYFP1_MOUSE (1-1277): 0: 2032: 85.68		WASF1_MOUSE (1-500): 1.12e-58: 204: 43.21
+	Mm
		1186412 CYFP1_MOUSE (1-1277): 0: 2032: 85.68		ANR17_MOUSE (114-474): 8.08e-23: 104: 11.36
+	Dm
		94639 CYFIP_DROME (1-1277): 0: 1898: 64.75		F2FB81_DROME (1-209): 1.43e-42: 162: 54.55
+	Dd
		1122141 PIRA_DICDI (7-1249): 0: 1445: 36.98		SCAR_DICDI (23-501): 1.2e-28: 119: 22.04