Interactor 1: CASP8 (Q8IRY7)
Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
Gene: Dredd
Interactor 2: NFKB1 (Q94527)
Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
Gene: Rel
Species: Drosophila melanogaster
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.67 | 1.00 | 0.820 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24891502, 19497884, unassigned4 |
| Identification Methods | enzymatic study, experimental interaction detection |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Ank_2~Peptidase_C14 |
| Common GO terms | GO:0002230 - positive regulation of defense response to virus by host GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006955 - immune response GO:0006963 - positive regulation of antibacterial peptide biosynthetic process and 5 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
