Protein: CASP6
Caspase-6 (CASP-6) (CSP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18 (Caspase-6 subunit p20); Caspase-6 subunit p11 (Caspase-6 subunit p10)]

Gene: CASP6
Organism: Homo sapiens
Interactions: 239
UniProt ID: P55212

Gene Ontology (top 5):
GO:0002218 - activation of innate immune response
GO:0004197 - cysteine-type endopeptidase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

936975

CASP6
Caspase-6

8

17

Small-scale

0.968

High

937002

CASP8
Caspase-8

3

17

Small-scale

0.845

High

840028

CASP3
Caspase-3

2

18

Small-scale

0.825

High

936981

XIAP
E3 ubiquitin-protein ligase XIAP

2

20

Small-scale

0.754

High

936976

MTPN
Myotrophin

1

1

High-throughput

0.691

High

936899

CASP7
Caspase-7

1

19

Small-scale

0.666

High

937079

CASPA
Caspase-10

1

17

Small-scale

0.647

High

842947

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

0

High-throughput

0.630

High

936987

GABP1
GA-binding protein subunit beta-1

1

0

High-throughput

0.630

High

529433

TAU
Microtubule-associated protein tau

2

7

Small-scale

0.602

High

936977

IPKA
cAMP-dependent protein kinase inhibitor alpha

2

0

High-throughput

0.580

High

937070

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

937089

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

937123

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

0

High-throughput

0.556

High

225550

AAKB2
5'-AMP-activated protein kinase subunit beta-2

1

3

High-throughput

0.541

High

936991

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

High-throughput

0.541

High

937142

NEMO
NF-kappa-B essential modulator

1

3

High-throughput

0.541

High

937129

PHF11
PHD finger protein 11

1

5

High-throughput

0.536

High

937141

IRAK3
Interleukin-1 receptor-associated kinase 3

1

1

Small-scale

0.536

High

48280

E2F8
Transcription factor E2F8

1

1

High-throughput

0.515

High

131374

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.515

High

134945

EMAL1
Echinoderm microtubule-associated protein-like 1

1

5

High-throughput

0.515

High

193763

PER1
Period circadian protein homolog 1

1

3

High-throughput

0.515

High

220080

TGM5
Protein-glutamine gamma-glutamyltransferase 5

1

2

High-throughput

0.515

High

249322

DLX3
Homeobox protein DLX-3

1

1

High-throughput

0.515

High

253069

PLIN3
Perilipin-3

1

2

High-throughput

0.515

High

261007

SHOX2
Short stature homeobox protein 2

1

2

High-throughput

0.515

High

369448

AACT
Alpha-1-antichymotrypsin

1

6

High-throughput

0.515

High

371575

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.515

High

413488

P53
Cellular tumor antigen p53

1

5

High-throughput

0.515

High

483441

ANXA4
Annexin A4

1

1

High-throughput

0.515

High

505884

JMJD7
Bifunctional peptidase and

1

1

High-throughput

0.515

High

605983

CAN2
Calpain-2 catalytic subunit

1

2

High-throughput

0.515

High

635066

CAN3
Calpain-3

1

4

High-throughput

0.515

High

647429

SCP2
Sterol carrier protein 2

1

2

High-throughput

0.515

High

652296

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

2

High-throughput

0.515

High

666817

CCNC
Cyclin-C

1

2

High-throughput

0.515

High

698206

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

1

High-throughput

0.515

High

708839

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

1

High-throughput

0.515

High

764579

CTNB1
Catenin beta-1

1

2

High-throughput

0.515

High

783211

TRI23
E3 ubiquitin-protein ligase TRIM23

1

1

High-throughput

0.515

High

843421

HD
Huntingtin

1

4

High-throughput

0.515

High

877431

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

1

High-throughput

0.515

High

928395

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.515

High

936978

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.515

High

936982

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

1

High-throughput

0.515

High

936985

TF65
Transcription factor p65

1

3

High-throughput

0.515

High

936988

RING1
E3 ubiquitin-protein ligase RING1

1

6

High-throughput

0.515

High

936989

PPARA
Peroxisome proliferator-activated receptor alpha

1

5

High-throughput

0.515

High

936992

TP53B
TP53-binding protein 1

1

3

High-throughput

0.515

High

936997

TBB2A
Tubulin beta-2A chain

1

3

High-throughput

0.515

High

937003

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.515

High

937004

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.515

High

937009

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

3

High-throughput

0.515

High

937010

ZN829
Zinc finger protein 829

1

2

High-throughput

0.515

High

937015

GLYR1
Cytokine-like nuclear factor N-PAC

1

3

High-throughput

0.515

High

937021

PKHG4
Puratrophin-1

1

2

High-throughput

0.515

High

937025

AKCL1
Aldo-keto reductase family 1 member C8

1

2

High-throughput

0.515

High

937032

LEG9C
Galectin-9C

1

2

High-throughput

0.515

High

937033

OTU7B
OTU domain-containing protein 7B

1

6

High-throughput

0.515

High

937036

ESRP1
Epithelial splicing regulatory protein 1

1

1

High-throughput

0.515

High

937050

TRI69
E3 ubiquitin-protein ligase TRIM69

1

5

High-throughput

0.515

High

937062

RNF10
E3 ubiquitin-protein ligase RNF10

1

2

High-throughput

0.515

High

937068

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.515

High

937074

CHMP7
Charged multivesicular body protein 7

1

1

High-throughput

0.515

High

937076

JADE3
Protein Jade-3

1

2

High-throughput

0.515

High

937077

DPF1
Zinc finger protein neuro-d4

1

5

High-throughput

0.515

High

937082

SPSB1
SPRY domain-containing SOCS box protein 1

1

6

High-throughput

0.515

High

937083

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.515

High

937086

HBAP1
HSPB1-associated protein 1

1

2

High-throughput

0.515

High

937092

ZN597
Zinc finger protein 597

1

3

High-throughput

0.515

High

937094

BTBD9
BTB/POZ domain-containing protein 9

1

4

High-throughput

0.515

High

937099

MEP50
Methylosome protein WDR77

1

1

High-throughput

0.515

High

937100

CAB45
45 kDa calcium-binding protein

1

1

High-throughput

0.515

High

937108

ATG10
Ubiquitin-like-conjugating enzyme ATG10

1

1

High-throughput

0.515

High

937118

SHLB2
Endophilin-B2

1

2

High-throughput

0.515

High

937119

HELLS
Lymphoid-specific helicase

1

5

High-throughput

0.515

High

937120

FGF21
Fibroblast growth factor 21

1

1

High-throughput

0.515

High

937121

BRWD1
Bromodomain and WD repeat-containing protein 1

1

5

High-throughput

0.515

High

937127

KLHL3
Kelch-like protein 3

1

3

High-throughput

0.515

High

937132

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.515

High

937138

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

1

High-throughput

0.515

High

937140

ACL7B
Actin-like protein 7B

1

7

High-throughput

0.515

High

937106

GBP3
Guanylate-binding protein 3

1

0

High-throughput

0.513

High

937115

IL26
Interleukin-26

1

0

High-throughput

0.513

High

937008

MK06
Mitogen-activated protein kinase 6

1

8

High-throughput

0.508

High

442649

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

464888

SP1
Transcription factor Sp1

1

2

Small-scale

0.501

High

936993

TRAF1
TNF receptor-associated factor 1

1

18

Small-scale

0.501

High

937000

UBE4A
Ubiquitin conjugation factor E4 A

1

2

Small-scale

0.501

High

937045

CSN6
COP9 signalosome complex subunit 6

1

5

Small-scale

0.501

High

937085

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.501

High

937135

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.501

High

936983

SATB1
DNA-binding protein SATB1

1

0

Small-scale

0.493

High

2014

A0A0A0MR05
Target of rapamycin complex subunit LST8

1

0

High-throughput

0.493

High

129689

CBX4
E3 SUMO-protein ligase CBX4

1

0

High-throughput

0.493

High

137325

ELL2
RNA polymerase II elongation factor ELL2

1

0

High-throughput

0.493

High

144087

WNT7A
Protein Wnt-7a

1

0

High-throughput

0.493

High

937113

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.493

High

937114

CD209
CD209 antigen

1

0

High-throughput

0.493

High

937116

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

High-throughput

0.493

High

937117

FERY3
Ferry endosomal RAB5 effector complex subunit 3

1

0

High-throughput

0.493

High

185084

TELT
Telethonin

1

0

High-throughput

0.493

High

229314

ZBT14
Zinc finger and BTB domain-containing protein 14

1

0

High-throughput

0.493

High

250521

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.493

High

261909

PP1RB
E3 ubiquitin-protein ligase PPP1R11

1

0

High-throughput

0.493

High

445456

APOA4
Apolipoprotein A-IV

1

0

High-throughput

0.493

High

483057

CLCA
Clathrin light chain A

1

0

High-throughput

0.493

High

617208

ATF4
Cyclic AMP-dependent transcription factor ATF-4

1

0

High-throughput

0.493

High

762079

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.493

High

785811

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.493

High

787737

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

High-throughput

0.493

High

791221

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

884297

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.493

High

930285

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.493

High

931183

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.493

High

936979

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.493

High

936990

RBBP4
Histone-binding protein RBBP4

1

0

High-throughput

0.493

High

936994

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.493

High

936996

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.493

High

936998

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.493

High

936999

BAAT
Bile acid-CoA:amino acid N-acyltransferase

1

0

High-throughput

0.493

High

937001

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

937005

NAB2
NGFI-A-binding protein 2

1

0

High-throughput

0.493

High

937022

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

1

0

High-throughput

0.493

High

937024

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.493

High

937029

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.493

High

937031

ADAL
N6-Methyl-AMP deaminase

1

0

High-throughput

0.493

High

937037

H3C
Histone H3.3C

1

0

High-throughput

0.493

High

937039

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.493

High

937043

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.493

High

937048

EST1A
Telomerase-binding protein EST1A

1

0

High-throughput

0.493

High

937051

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.493

High

937052

ARCH
Protein archease

1

0

High-throughput

0.493

High

937059

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.493

High

937061

MINY1
Ubiquitin carboxyl-terminal hydrolase MINDY-1

1

0

High-throughput

0.493

High

937063

KCD17
BTB/POZ domain-containing protein KCTD17

1

0

High-throughput

0.493

High

937067

PEPL1
Probable aminopeptidase NPEPL1

1

0

High-throughput

0.493

High

937069

NUP37
Nucleoporin Nup37

1

0

High-throughput

0.493

High

937078

SYMPK
Symplekin

1

0

High-throughput

0.493

High

937081

TET5B
Terminal nucleotidyltransferase 5B

1

0

High-throughput

0.493

High

937087

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.493

High

937088

SNF8
Vacuolar-sorting protein SNF8

1

0

High-throughput

0.493

High

937091

ZN333
Zinc finger protein 333

1

0

High-throughput

0.493

High

937093

KAD8
Adenylate kinase 8

1

0

High-throughput

0.493

High

937095

ALKB3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

1

0

High-throughput

0.493

High

937096

PCY2
Ethanolamine-phosphate cytidylyltransferase

1

0

High-throughput

0.493

High

937097

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.493

High

937098

DPYL5
Dihydropyrimidinase-related protein 5

1

0

High-throughput

0.493

High

937101

HAUS8
HAUS augmin-like complex subunit 8

1

0

High-throughput

0.493

High

937102

PHF23
PHD finger protein 23

1

0

High-throughput

0.493

High

937103

MTNA
Methylthioribose-1-phosphate isomerase

1

0

High-throughput

0.493

High

937104

SHP1L
Testicular spindle-associated protein SHCBP1L

1

0

High-throughput

0.493

High

937105

SPY4
Protein sprouty homolog 4

1

0

High-throughput

0.493

High

937107

CK054
Ester hydrolase C11orf54

1

0

High-throughput

0.493

High

937109

LHX5
LIM/homeobox protein Lhx5

1

0

High-throughput

0.493

High

937111

PAAT
ATPase PAAT

1

0

High-throughput

0.493

High

937112

GBB4
Guanine nucleotide-binding protein subunit beta-4

1

0

High-throughput

0.493

High

937125

VPS54
Vacuolar protein sorting-associated protein 54

1

0

High-throughput

0.493

High

937131

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.493

High

937133

JUPI1
Jupiter microtubule associated homolog 1

1

0

High-throughput

0.493

High

937134

OCTC
Peroxisomal carnitine O-octanoyltransferase

1

0

High-throughput

0.493

High

937136

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

1

0

High-throughput

0.493

High

937137

NAGA
N-acetylglucosamine-6-phosphate deacetylase

1

0

High-throughput

0.493

High

937041

HACD2
Very-long-chain

1

1

High-throughput

0.489

High

936995

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.486

High

937006

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.486

High

241214

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

384647

CRYAB
Alpha-crystallin B chain

1

10

Small-scale

0.479

High

767805

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

937044

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

937139

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

Small-scale

0.479

High

46756

A0A384MDV8
Plasma protease C1 inhibitor

1

7

High-throughput

0.470

High

85127

B7Z3E8
cDNA FLJ51208

1

2

High-throughput

0.470

High

690701

AOFB
Amine oxidase [flavin-containing] B

1

2

High-throughput

0.470

High

867704

RGR
RPE-retinal G protein-coupled receptor

1

1

High-throughput

0.470

High

936986

Q05CR2
ZNF248 protein

1

1

High-throughput

0.470

High

937014

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

1

High-throughput

0.470

High

937023

KRBX4
KRAB domain-containing protein 4

1

5

High-throughput

0.470

High

937040

ASCL4
Achaete-scute homolog 4

1

1

High-throughput

0.470

High

937053

LRC56
Leucine-rich repeat-containing protein 56

1

1

High-throughput

0.470

High

937057

KT222
Keratin-like protein KRT222

1

3

High-throughput

0.470

High

937060

KLH36
Kelch-like protein 36

1

3

High-throughput

0.470

High

937071

KLDC4
Kelch domain-containing protein 4

1

3

High-throughput

0.470

High

937090

LOXL4
Lysyl oxidase homolog 4

1

2

High-throughput

0.470

High

937128

TEFF2
Tomoregulin-2

1

2

High-throughput

0.470

High

421796

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.445

High

936980

NUCB2
Nucleobindin-2

1

5

Small-scale

0.445

High

937018

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

1

Small-scale

0.445

High

937030

A16L1
Autophagy-related protein 16-1

1

4

Small-scale

0.445

High

937073

HDAC7
Histone deacetylase 7

1

6

Small-scale

0.445

High

936984

NUCB1
Nucleobindin-1

1

5

Small-scale

0.407

High

937130

RWD2A
RWD domain-containing protein 2A

1

0

High-throughput

0.279

Low

60829

MBPHL
Myosin-binding protein H-like

1

0

High-throughput

0.268

Low

66167

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.268

Low

178748

SCAM1
Secretory carrier-associated membrane protein 1

1

0

High-throughput

0.268

Low

325534

YIF1A
Protein YIF1A

1

0

High-throughput

0.268

Low

341410

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.268

Low

384247

CO2A1
Collagen alpha-1(II) chain

1

0

High-throughput

0.268

Low

441415

CHLE
Cholinesterase

1

0

High-throughput

0.268

Low

516631

LYNX1
Ly-6/neurotoxin-like protein 1

1

0

High-throughput

0.268

Low

516830

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.268

Low

561972

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

690012

CRBB3
Beta-crystallin B3

1

0

High-throughput

0.268

Low

833494

PTGDS
Prostaglandin-H2 D-isomerase

1

0

High-throughput

0.268

Low

937007

LPAL2
Putative apolipoprotein(a)-like protein 2

1

0

High-throughput

0.268

Low

937011

CMA1D
Protein CIMAP1D

1

0

High-throughput

0.268

Low

937012

CC036
Uncharacterized protein C3orf36

1

0

High-throughput

0.268

Low

937013

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

937016

F135B
Protein FAM135B

1

0

High-throughput

0.268

Low

937017

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

0

High-throughput

0.268

Low

937019

Q53NU3
cDNA, FLJ92284

1

0

High-throughput

0.268

Low

937020

CYBR1
Plasma membrane ascorbate-dependent reductase CYBRD1

1

0

High-throughput

0.268

Low

937026

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.268

Low

937027

EF1DL
Putative elongation factor 1-delta-like protein

1

0

High-throughput

0.268

Low

937028

RUAS1
Putative uncharacterized protein RUSC1-AS1

1

0

High-throughput

0.268

Low

937034

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.268

Low

937035

OGFD2
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2

1

0

High-throughput

0.268

Low

937038

CNST
Consortin

1

0

High-throughput

0.268

Low

937042

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.268

Low

937046

NUP54
Nucleoporin p54

1

0

High-throughput

0.268

Low

937047

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

937049

Q86V28
AP-1 complex subunit gamma

1

0

High-throughput

0.268

Low

937054

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

937055

CF218
Putative uncharacterized protein encoded by LINC00518

1

0

High-throughput

0.268

Low

937056

F177A
Protein FAM177A1

1

0

High-throughput

0.268

Low

937058

CD033
UPF0462 protein C4orf33

1

0

High-throughput

0.268

Low

937064

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.268

Low

937065

WDR31
WD repeat-containing protein 31

1

0

High-throughput

0.268

Low

937066

PRCA1
Protein PROCA1

1

0

High-throughput

0.268

Low

937072

RAB2B
Ras-related protein Rab-2B

1

0

High-throughput

0.268

Low

937075

ABEC4
Putative C->U-editing enzyme APOBEC-4

1

0

High-throughput

0.268

Low

937080

MAL2
Protein MAL2

1

0

High-throughput

0.268

Low

937084

MID49
Mitochondrial dynamics protein MID49

1

0

High-throughput

0.268

Low

937110

NAA60
N-alpha-acetyltransferase 60

1

0

High-throughput

0.268

Low

937122

SEM4G
Semaphorin-4G

1

0

High-throughput

0.268

Low

937124

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

937126

CRCT1
Cysteine-rich C-terminal protein 1

1

0

High-throughput

0.268

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025