HitPredict

Interactor 1: SH3G3 (Q99963)
Endophilin-A3 (EEN-B2) (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3)
Gene: SH3GL3

Interactor 2: DYN3 (Q9UQ16)
Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)
Gene: DNM3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18602463
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Hs			1 869
+	Hs
		1307442 SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Hs
		1307425 SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30		DYN3_HUMAN (1-869): 0: 1080: 100.00
+	Hs
		840808 SH3G3_HUMAN (1-347): 9.83e-90: 274: 100.00		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Mm
		760455 SH3G3_MOUSE (1-346): 1.4e-88: 271: 86.71		DYN1_MOUSE (1-847): 0: 1035: 78.90
+	Hs
		840807 SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		983405 SH3G2_HUMAN (1-347): 8.3e-86: 264: 65.91		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Mm
		760454 SH3G2_MOUSE (1-347): 4.35e-85: 262: 65.63		DYN1_MOUSE (1-847): 0: 1035: 78.90
+	Rn
		192355 SH3G3_RAT (1-346): 1.05e-86: 266: 86.99		DYN1_RAT (1-852): 0: 1028: 78.22
+	Rn
		192351 SH3G2_RAT (1-347): 3.62e-85: 262: 65.63		DYN1_RAT (1-852): 0: 1028: 78.22
+	Hs
		840806 SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Hs
		983404 SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30		DYN1_HUMAN (1-852): 0: 1035: 78.56
+	Mm
		760453 SH3G1_MOUSE (1-347): 3.99e-79: 247: 66.85		DYN1_MOUSE (1-847): 0: 1035: 78.90
+	Rn
		193636 SH3G1_RAT (1-347): 1.14e-78: 246: 66.30		DYN1_RAT (1-852): 0: 1028: 78.22
+	Mm
		760467 SHLB1_MOUSE (10-342): 1.64e-66: 215: 23.65		DYN1_MOUSE (1-847): 0: 1035: 78.90
+	Mm
		760473 SRC8_MOUSE (7-343): 2.48e-52: 183: 13.24		DYN2_MOUSE (1-869): 0: 1038: 79.21
+	Hs
		840692 SRC8_HUMAN (7-343): 2.64e-50: 177: 14.49		DYN2_HUMAN (1-869): 0: 1041: 79.21
+	Dm
		649303 SH3G3_DROME (1-346): 3.61e-70: 225: 49.19		DYN_DROME (6-861): 0: 974: 64.46
+	Ce
		70029 SH3GH_CAEEL (1-345): 1.27e-65: 213: 42.93		DYN1_CAEEL (3-815): 0: 947: 62.09
+	Hs
		128631 SH3G1_HUMAN (1-347): 7.8e-80: 249: 66.30		DNM1L_HUMAN (6-750): 0: 788: 38.25
+	Hs
		128646 SHLB2_HUMAN (10-342): 1.05e-58: 196: 20.57		DNM1L_HUMAN (6-750): 0: 788: 38.25