Protein: SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SFL) (SHFL) (Interferon-regulated antiviral protein) (IRAV) (Repressor of yield of DENV protein) (RyDEN)

Gene: SHFL
Organism: Homo sapiens
Interactions: 106
UniProt ID: Q9NUL5

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685964

KRA59
Keratin-associated protein 5-9

3

18

High-throughput

0.675

High

950418

KR107
Keratin-associated protein 10-7

3

15

High-throughput

0.675

High

950700

KR108
Keratin-associated protein 10-8

3

17

High-throughput

0.675

High

950903

KR109
Keratin-associated protein 10-9

3

17

High-throughput

0.675

High

1230279

K1C40
Keratin, type I cytoskeletal 40

3

1

High-throughput

0.675

High

1410104

KR412
Keratin-associated protein 4-12

3

19

High-throughput

0.675

High

1419038

KRA92
Keratin-associated protein 9-2

3

18

High-throughput

0.675

High

1093973

TRAF1
TNF receptor-associated factor 1

3

0

High-throughput

0.646

High

1206002

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

0

High-throughput

0.646

High

1407106

MDFI
MyoD family inhibitor

3

0

High-throughput

0.646

High

1449885

ADIP
Afadin- and alpha-actinin-binding protein

3

0

High-throughput

0.646

High

1224918

TENS2
Tensin-2

3

0

High-throughput

0.639

High

1449881

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

3

0

High-throughput

0.639

High

505386

KRA23
Keratin-associated protein 2-3

2

17

High-throughput

0.633

High

894198

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

1277425

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.633

High

950134

KR105
Keratin-associated protein 10-5

2

17

High-throughput

0.611

High

1059751

KRA11
Keratin-associated protein 1-1

2

18

High-throughput

0.606

High

1146185

K1H1
Keratin, type I cuticular Ha1

2

1

High-throughput

0.606

High

1235816

KRA57
Keratin-associated protein 5-7

2

15

High-throughput

0.606

High

1307464

KRA13
Keratin-associated protein 1-3

2

18

High-throughput

0.606

High

1419016

KRA93
Keratin-associated protein 9-3

2

18

High-throughput

0.606

High

1419056

KR411
Keratin-associated protein 4-11

2

18

High-throughput

0.606

High

1419074

KRA45
Keratin-associated protein 4-5

2

18

High-throughput

0.606

High

1419085

KRA44
Keratin-associated protein 4-4

2

18

High-throughput

0.606

High

1419155

KRA15
Keratin-associated protein 1-5

2

19

High-throughput

0.606

High

269395

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.580

High

332589

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.580

High

949629

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.580

High

1061897

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1081494

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1143912

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

2

0

High-throughput

0.580

High

1216162

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.580

High

1236160

TEN4
Teneurin-4

2

0

High-throughput

0.580

High

1348537

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

1371455

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.580

High

1397252

LURA1
Leucine rich adaptor protein 1

2

0

High-throughput

0.580

High

1402057

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1418974

KR171
Keratin-associated protein 17-1

2

0

High-throughput

0.580

High

1448363

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

1449882

KLF15
Krueppel-like factor 15

2

0

High-throughput

0.580

High

1449886

ZN835
Zinc finger protein 835

2

0

High-throughput

0.580

High

221190

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.573

High

1419097

KRA42
Keratin-associated protein 4-2

1

18

High-throughput

0.573

High

1449883

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

4

High-throughput

0.573

High

1311479

TRI42
Tripartite motif-containing protein 42

2

4

High-throughput

0.553

High

928564

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.549

High

587232

ITF2
Transcription factor 4

1

0

High-throughput

0.549

High

848184

MAGA1
Melanoma-associated antigen 1

1

0

High-throughput

0.549

High

1104684

IKZF1
DNA-binding protein Ikaros

1

0

High-throughput

0.549

High

1218023

MYOME
Myomegalin

1

0

High-throughput

0.549

High

1389800

DTBP1
Dysbindin

1

0

High-throughput

0.549

High

1411332

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.549

High

1380867

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.541

High

1419307

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.541

High

186591

TRI18
E3 ubiquitin-protein ligase Midline-1

1

4

High-throughput

0.536

High

1254281

UBR3
E3 ubiquitin-protein ligase UBR3

1

1

High-throughput

0.536

High

1311115

UBR1
E3 ubiquitin-protein ligase UBR1

1

1

High-throughput

0.536

High

1232603

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

1279767

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

1419147

KRA24
Keratin-associated protein 2-4

1

17

High-throughput

0.515

High

124844

AIP
AH receptor-interacting protein

1

0

High-throughput

0.513

High

451579

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.513

High

877245

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

1048295

KPCT
Protein kinase C theta type

1

0

High-throughput

0.513

High

1151668

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.513

High

1214983

RN187
E3 ubiquitin-protein ligase RNF187

1

0

High-throughput

0.513

High

1309839

WDFY1
WD repeat and FYVE domain-containing protein 1

1

0

High-throughput

0.513

High

1326554

CARME
Carnosine N-methyltransferase

1

0

High-throughput

0.513

High

1387038

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.513

High

1387851

ZBT10
Zinc finger and BTB domain-containing protein 10

1

0

High-throughput

0.513

High

1389398

RNF31
E3 ubiquitin-protein ligase RNF31

1

0

High-throughput

0.513

High

1403662

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

0

High-throughput

0.513

High

1418812

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.513

High

246158

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

415888

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

705574

GRN
Progranulin

1

0

High-throughput

0.493

High

1449887

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

642

NBPFJ
NBPF family member NBPF19

1

1

High-throughput

0.481

High

949787

KR101
Keratin-associated protein 10-1

1

17

High-throughput

0.481

High

950018

KR103
Keratin-associated protein 10-3

1

19

High-throughput

0.481

High

1449884

CAPS1
Calcium-dependent secretion activator 1

1

1

High-throughput

0.481

High

60255

A2RRN7
CADPS protein

1

1

High-throughput

0.470

High

517122

NT2NC
Notch homolog 2 N-terminal-like protein C

1

2

High-throughput

0.470

High

373270

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

401564

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

872788

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1095818

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

Small-scale

0.458

High

1211674

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

Small-scale

0.458

High

1367388

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1436501

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1233955

Q6ICH2
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.437

High

765927

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

73461

B2CML4
single-stranded DNA cytosine deaminase

1

1

High-throughput

0.407

High

1244399

DRIC1
Aspartate-rich protein 1

3

0

High-throughput

0.352

High

1250326

ATL4
ADAMTS-like protein 4

3

0

High-throughput

0.352

High

1395356

CC136
Coiled-coil domain-containing protein 136

2

0

High-throughput

0.330

High

70502

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

1180128

VWC2
Brorin

2

0

High-throughput

0.316

High

1369113

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.316

High

1017814

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1201334

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

109518

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

301726

WFS1
Wolframin

1

0

High-throughput

0.268

Low

1244015

F199X
Protein FAM199X

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025