HitPredict

Interactor 1: ASXL1 (Q8IXJ9)
Polycomb group protein ASXL1 (Additional sex combs-like protein 1)
Gene: ASXL1

Interactor 2: MBD6 (Q96DN6)
Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)
Gene: MBD6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	36180891, 27705803
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1541 Hs			1 1003
+	Hs
		1312435 ASXL1_HUMAN (1-1541): 0: 2382: 100.00		MBD5_HUMAN (1-547): 6.86e-27: 121: 25.57
+	Hs
		1312397 ASXL1_HUMAN (1-1541): 0: 2382: 100.00		KMT2C_HUMAN (294-823): 6.68e-14: 78.9: 18.80
+	Hs
		1260613 ASXL2_HUMAN (1474-1541): 1.15e-23: 111: 55.88		MBD6_HUMAN (1-1003): 1e-98: 335: 100.00
+	Hs
		1387738 ASXL3_HUMAN (363-661): 2.64e-10: 67.9: 25.72		MBD6_HUMAN (1-1003): 1e-98: 335: 100.00
+	Hs
		1260630 ASXL2_HUMAN (1474-1541): 1.15e-23: 111: 55.88		MBD5_HUMAN (1-547): 6.86e-27: 121: 25.57
+	Hs
		1260603 ASXL2_HUMAN (1474-1541): 1.15e-23: 111: 55.88		KMT2C_HUMAN (294-823): 6.68e-14: 78.9: 18.80
+	Hs
		1421200 ASXL3_HUMAN (363-661): 2.64e-10: 67.9: 25.72		MBD5_HUMAN (1-547): 6.86e-27: 121: 25.57
+	Hs
		1338273 ASXL3_HUMAN (363-661): 2.64e-10: 67.9: 25.72		KMT2C_HUMAN (294-823): 6.68e-14: 78.9: 18.80