Protein: MBD5
Methyl-CpG-binding domain protein 5 (Methyl-CpG-binding protein MBD5)

Gene: MBD5
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9P267

Gene Ontology (top 5):
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome
GO:0007399 - nervous system development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1260630

ASXL2
Putative Polycomb group protein ASXL2

4

6

High-throughput

0.694

High

1446246

UBE2T
Ubiquitin-conjugating enzyme E2 T

3

1

High-throughput

0.667

High

1143020

PMVK
Phosphomevalonate kinase

3

0

High-throughput

0.638

High

1312435

ASXL1
Polycomb group protein ASXL1

2

6

High-throughput

0.611

High

1364639

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

2

High-throughput

0.611

High

1429167

NAA50
N-alpha-acetyltransferase 50

2

0

High-throughput

0.602

High

249675

SNX3
Sorting nexin-3

2

0

High-throughput

0.585

High

909403

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

0

High-throughput

0.585

High

1278822

HDGR2
Hepatoma-derived growth factor-related protein 2

2

0

High-throughput

0.585

High

783762

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.580

High

248251

NDK8
Putative nucleoside diphosphate kinase

2

0

High-throughput

0.528

High

668737

APC
Adenomatous polyposis coli protein

1

0

High-throughput

0.518

High

1372325

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

1085148

SCRN1
Secernin-1

1

0

High-throughput

0.513

High

853423

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.493

High

1454317

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

48395

UBA6
Ubiquitin-like modifier-activating enzyme 6

1

1

High-throughput

0.479

High

141686

DDX3X
ATP-dependent RNA helicase DDX3X

1

5

High-throughput

0.479

High

186088

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.479

High

425062

ADT2
ADP/ATP translocase 2

1

2

High-throughput

0.479

High

447528

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

476408

K1C16
Keratin, type I cytoskeletal 16

1

3

High-throughput

0.479

High

485751

RU2A
U2 small nuclear ribonucleoprotein A'

1

1

High-throughput

0.479

High

487838

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

528367

THIO
Thioredoxin

1

1

High-throughput

0.479

High

542678

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.479

High

558457

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

576583

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.479

High

577915

PLAK
Junction plakoglobin

1

4

High-throughput

0.479

High

608773

DDX5
Probable ATP-dependent RNA helicase DDX5

1

5

High-throughput

0.479

High

616373

RCC1
Regulator of chromosome condensation

1

3

High-throughput

0.479

High

660182

COF1
Cofilin-1

1

1

High-throughput

0.479

High

728002

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

729484

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.479

High

876207

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.479

High

881327

FAS
Fatty acid synthase

1

1

High-throughput

0.479

High

905504

HCFC1
Host cell factor 1

1

1

High-throughput

0.479

High

911136

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.479

High

938414

NH2L1
NHP2-like protein 1

1

1

High-throughput

0.479

High

965295

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

974858

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

High-throughput

0.479

High

980462

H4
Histone H4

1

1

High-throughput

0.479

High

983074

RS25
Small ribosomal subunit protein eS25

1

2

High-throughput

0.479

High

991741

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.479

High

992360

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

1010730

DCD
Dermcidin

1

1

High-throughput

0.479

High

1016658

SRSF3
Serine/arginine-rich splicing factor 3

1

3

High-throughput

0.479

High

1017503

FOXK1
Forkhead box protein K1

1

2

High-throughput

0.479

High

1061192

SRSF1
Serine/arginine-rich splicing factor 1

1

3

High-throughput

0.479

High

1146854

PCBP1
Poly(rC)-binding protein 1

1

4

High-throughput

0.479

High

1148070

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.479

High

1210547

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.479

High

1333174

KDM1B
Lysine-specific histone demethylase 2

1

1

High-throughput

0.479

High

1335019

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1363643

H1X
Histone H1.10

1

1

High-throughput

0.479

High

1369412

DDX17
Probable ATP-dependent RNA helicase DDX17

1

5

High-throughput

0.479

High

1370864

FUBP2
Far upstream element-binding protein 2

1

4

High-throughput

0.479

High

1391820

AURKB
Aurora kinase B

1

1

High-throughput

0.479

High

1407606

TCPH
T-complex protein 1 subunit eta

1

5

High-throughput

0.479

High

1410761

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.479

High

1416886

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

2

High-throughput

0.479

High

1420469

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.479

High

1421200

ASXL3
Putative Polycomb group protein ASXL3

1

6

High-throughput

0.479

High

1429811

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1451807

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.479

High

1453418

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

2

High-throughput

0.479

High

1454291

RCC2
Protein RCC2

1

3

High-throughput

0.479

High

962585

RHOA
Transforming protein RhoA

1

0

High-throughput

0.458

High

1036814

DSG1
Desmoglein-1

1

0

High-throughput

0.458

High

1114510

CUL3
Cullin-3

1

0

High-throughput

0.458

High

999611

HBG1
Hemoglobin subunit gamma-1

1

1

High-throughput

0.437

High

1047494

K1C17
Keratin, type I cytoskeletal 17

1

3

High-throughput

0.437

High

1199729

KLH22
Kelch-like protein 22

1

0

High-throughput

0.426

High

998893

H31
Histone H3.1

1

0

Small-scale

0.391

High

1031134

HMCS1
Hydroxymethylglutaryl-CoA synthase, cytoplasmic

3

0

High-throughput

0.347

High

939659

BID
BH3-interacting domain death agonist

2

0

High-throughput

0.328

High

1362065

LZIC
Protein LZIC

2

0

High-throughput

0.328

High

976785

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.318

High

1454316

S18L2
SS18-like protein 2

2

0

High-throughput

0.316

High

1439273

K1549
UPF0606 protein KIAA1549

1

0

Small-scale

0.265

Low

106777

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

627723

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.249

Low

1232322

CARL2
Capping protein, Arp2/3 and myosin-I linker protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025