Protein: MBD6
Methyl-CpG-binding domain protein 6 (Methyl-CpG-binding protein MBD6)

Gene: MBD6
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q96DN6

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1260613

ASXL2
Putative Polycomb group protein ASXL2

7

20

High-throughput

0.748

High

1312407

ASXL1
Polycomb group protein ASXL1

2

8

High-throughput

0.611

High

1364511

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

2

High-throughput

0.611

High

1023144

RBM10
RNA-binding protein 10

2

2

High-throughput

0.606

High

222172

NCK2
Cytoplasmic protein NCK2

2

15

High-throughput

0.553

High

1387746

DUS12
Dual specificity protein phosphatase 12

1

0

High-throughput

0.518

High

1387747

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

505600

ATX1L
Ataxin-1-like

1

2

High-throughput

0.481

High

141610

DDX3X
ATP-dependent RNA helicase DDX3X

1

7

High-throughput

0.479

High

143182

NFIB
Nuclear factor 1 B-type

1

11

High-throughput

0.479

High

185919

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

7

High-throughput

0.479

High

214898

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

5

High-throughput

0.479

High

256949

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.479

High

424989

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.479

High

447302

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

474199

NFIC
Nuclear factor 1 C-type

1

15

High-throughput

0.479

High

476372

K1C16
Keratin, type I cytoskeletal 16

1

5

High-throughput

0.479

High

485707

RU2A
U2 small nuclear ribonucleoprotein A'

1

4

High-throughput

0.479

High

487627

PARP1
Poly [ADP-ribose] polymerase 1

1

13

High-throughput

0.479

High

528321

THIO
Thioredoxin

1

4

High-throughput

0.479

High

542614

TOP2A
DNA topoisomerase 2-alpha

1

2

High-throughput

0.479

High

558322

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

576496

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

2

High-throughput

0.479

High

577853

PLAK
Junction plakoglobin

1

13

High-throughput

0.479

High

608696

DDX5
Probable ATP-dependent RNA helicase DDX5

1

8

High-throughput

0.479

High

616349

RCC1
Regulator of chromosome condensation

1

5

High-throughput

0.479

High

658331

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

660139

COF1
Cofilin-1

1

2

High-throughput

0.479

High

675621

TYY1
Transcriptional repressor protein YY1

1

5

High-throughput

0.479

High

727924

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.479

High

729396

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

6

High-throughput

0.479

High

775898

HNF1B
Hepatocyte nuclear factor 1-beta

1

16

High-throughput

0.479

High

905459

HCFC1
Host cell factor 1

1

8

High-throughput

0.479

High

911046

IMA1
Importin subunit alpha-1

1

5

High-throughput

0.479

High

938392

NH2L1
NHP2-like protein 1

1

2

High-throughput

0.479

High

944721

KLF3
Krueppel-like factor 3

1

9

High-throughput

0.479

High

959901

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.479

High

965152

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.479

High

970031

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.479

High

971863

1433E
14-3-3 protein epsilon

1

2

High-throughput

0.479

High

974812

SMD3
Small nuclear ribonucleoprotein Sm D3

1

1

High-throughput

0.479

High

980118

H4
Histone H4

1

7

High-throughput

0.479

High

983020

RS25
Small ribosomal subunit protein eS25

1

2

High-throughput

0.479

High

986623

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

991665

DYL1
Dynein light chain 1, cytoplasmic

1

3

High-throughput

0.479

High

992296

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.479

High

1008282

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.479

High

1016555

SRSF3
Serine/arginine-rich splicing factor 3

1

8

High-throughput

0.479

High

1017465

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.479

High

1029724

FOXK2
Forkhead box protein K2

1

8

High-throughput

0.479

High

1061086

SRSF1
Serine/arginine-rich splicing factor 1

1

8

High-throughput

0.479

High

1089794

ILF3
Interleukin enhancer-binding factor 3

1

11

High-throughput

0.479

High

1120282

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

4

High-throughput

0.479

High

1131796

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.479

High

1136833

MO4L2
Mortality factor 4-like protein 2

1

3

High-throughput

0.479

High

1146765

PCBP1
Poly(rC)-binding protein 1

1

8

High-throughput

0.479

High

1146967

PCBP2
Poly(rC)-binding protein 2

1

8

High-throughput

0.479

High

1147997

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.479

High

1210500

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.479

High

1278962

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

12

High-throughput

0.479

High

1333167

KDM1B
Lysine-specific histone demethylase 2

1

6

High-throughput

0.479

High

1334754

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

1363597

H1X
Histone H1.10

1

1

High-throughput

0.479

High

1369344

DDX17
Probable ATP-dependent RNA helicase DDX17

1

8

High-throughput

0.479

High

1370821

FUBP2
Far upstream element-binding protein 2

1

8

High-throughput

0.479

High

1387733

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1387734

RBM14
RNA-binding protein 14

1

3

High-throughput

0.479

High

1387736

MBB1A
Myb-binding protein 1A

1

1

High-throughput

0.479

High

1387737

DPY30
Protein dpy-30 homolog

1

3

High-throughput

0.479

High

1387738

ASXL3
Putative Polycomb group protein ASXL3

1

16

High-throughput

0.479

High

1387739

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

1387740

DDX18
ATP-dependent RNA helicase DDX18

1

9

High-throughput

0.479

High

1387741

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.479

High

1387742

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

1

High-throughput

0.479

High

1387745

MO4L1
Mortality factor 4-like protein 1

1

3

High-throughput

0.479

High

837784

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

969356

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

977329

RS4X
Small ribosomal subunit protein eS4, X isoform

1

0

High-throughput

0.458

High

1323825

INT1
Integrator complex subunit 1

1

0

High-throughput

0.458

High

1387744

HOP2
Homologous-pairing protein 2 homolog

1

0

High-throughput

0.458

High

245643

ZEB2
Zinc finger E-box-binding homeobox 2

1

2

Small-scale

0.445

High

209637

SERA
D-3-phosphoglycerate dehydrogenase

1

5

High-throughput

0.437

High

259035

DNJA2
DnaJ homolog subfamily A member 2

1

5

High-throughput

0.437

High

876113

TCPE
T-complex protein 1 subunit epsilon

1

6

High-throughput

0.437

High

881271

FAS
Fatty acid synthase

1

3

High-throughput

0.437

High

999608

HBG1
Hemoglobin subunit gamma-1

1

2

High-throughput

0.437

High

1010692

DCD
Dermcidin

1

1

High-throughput

0.437

High

1047470

K1C17
Keratin, type I cytoskeletal 17

1

5

High-throughput

0.437

High

1387735

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.437

High

1387743

RCC2
Protein RCC2

1

5

High-throughput

0.437

High


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Last updated: 11Aug2025