HitPredict

Interactor 1: SLX4 (Q8IY92)
Structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
Gene: SLX4

Interactor 2: ARIP4 (Q9Y4B4)
Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2)
Gene: RAD54L2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	37071664, 19596235
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1834 Hs			1 1467
+	Hs
		855472 SLX4_HUMAN (1-1834): 0: 1473: 100.00		ATRX_HUMAN (23-1102): 0: 622: 28.75
+	Hs
		1314428 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD8_HUMAN (5-1158): 2.55e-180: 597: 16.61
+	Hs
		1186489 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD9_HUMAN (2-1156): 5.94e-176: 586: 16.04
+	Hs
		903409 SLX4_HUMAN (1-1834): 0: 1473: 100.00		SMCA4_HUMAN (23-1125): 2.82e-179: 580: 16.78
+	Hs
		1132819 SLX4_HUMAN (1-1834): 0: 1473: 100.00		CHD4_HUMAN (114-1305): 4.93e-176: 576: 14.44
+	Hs
		1314436 SLX4_HUMAN (1-1834): 0: 1473: 100.00		HELLS_HUMAN (116-938): 1.17e-180: 561: 21.18
+	Hs
		1042890 SLX4_HUMAN (1-1834): 0: 1473: 100.00		ERCC6_HUMAN (300-891): 1.09e-50: 199: 28.36
+	Hs
		854319 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD8_HUMAN (5-1158): 2.55e-180: 597: 16.61
+	Hs
		854358 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD7_HUMAN (4-1297): 4.59e-178: 592: 15.00
+	Hs
		855429 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		ATRX_HUMAN (23-1102): 0: 622: 28.75
+	Hs
		854060 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD4_HUMAN (114-1305): 4.93e-176: 576: 14.44
+	Hs
		854021 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		CHD3_HUMAN (108-1358): 1.25e-174: 574: 14.39
+	Hs
		853939 KI67_HUMAN (889-1833): 6.4e-23: 109: 11.20		SMCA2_HUMAN (23-1109): 1.02e-174: 566: 16.58
+	Hs
		1129591 MDC1_HUMAN (757-1462): 4.4e-17: 90.6: 10.56		CHD4_HUMAN (114-1305): 4.93e-176: 576: 14.44
+	Hs
		1030699 ANK2_HUMAN (790-1770): 6.65e-09: 63.5: 12.86		CHD8_HUMAN (5-1158): 2.55e-180: 597: 16.61
+	Hs
		903530 CABIN_HUMAN (864-1723): 7.69e-09: 63.1: 10.42		SMCA4_HUMAN (23-1125): 2.82e-179: 580: 16.78