HitPredict

Interactor 1: SYNE4 (Q8N205)
Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4)
Gene: SYNE4

Interactor 2: KLC4 (Q9NSK0)
Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8)
Gene: KLC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.50	0.644

Property	Details
Experiments	25416956, 26186194, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 404 Hs			1 619
+	Hs
		1323883 SYNE4_HUMAN (1-404): 0: 704: 100.00		KLC2_HUMAN (12-619): 2.15e-106: 335: 68.65
+	Hs
		1060544 SYNE4_HUMAN (1-404): 0: 704: 100.00		KLC1_HUMAN (1-544): 8.98e-98: 311: 68.99
+	Mm
		1298751 SYNE4_MOUSE (1-404): 0: 618: 65.35		KLC4_MOUSE (1-619): 1.53e-123: 380: 94.35
+	Mm
		312237 SYNE4_MOUSE (1-404): 0: 618: 65.35		KLC2_MOUSE (1-611): 1.25e-103: 328: 67.43
+	Hs
		1242675 SYNE4_HUMAN (1-404): 0: 704: 100.00		KLC3_HUMAN (290-617): 7.47e-28: 119: 32.74
+	Mm
		312232 SYNE4_MOUSE (1-404): 0: 618: 65.35		KLC1_MOUSE (376-580): 8.06e-10: 63.5: 18.18
+	Mm
		1298750 SYNE4_MOUSE (1-404): 0: 618: 65.35		KLC3_MOUSE (51-255): 5.6e-09: 60.8: 14.55