HitPredict

Interactor 1: RC3H2 (Q9HBD1)
Roquin-2 (EC 2.3.2.27) (Membrane-associated nucleic acid-binding protein) (RING finger and CCCH-type zinc finger domain-containing protein 2) (RING finger protein 164) (RING-type E3 ubiquitin transferase Roquin-2)
Gene: RC3H2

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	30209976
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~zf-CCCH
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1191 Hs			1 559
+	Hs
		1054598 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1288632 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1272104 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		1329984 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PABP3_HUMAN (479-559): 6.17e-13: 73.4: 19.75
+	Hs
		1031467 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516698 RC3H2_HUMAN (1-1191): 0: 1105: 100.00		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		1136342 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00
+	Hs
		1054374 RC3H1_HUMAN (1-1108): 0: 788: 49.30		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1136223 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1136210 RC3H1_HUMAN (1-1108): 0: 788: 49.30		CELF1_HUMAN (98-214): 1.29e-17: 87.5: 26.50
+	Hs
		1136287 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PABP3_HUMAN (479-559): 6.17e-13: 73.4: 19.75
+	Hs
		1031360 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516550 RC3H1_HUMAN (1-1108): 0: 788: 49.30		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		1054314 MDC1_HUMAN (442-806): 1.14e-11: 71.8: 12.21		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		257643 ANR17_HUMAN (335-957): 1.44e-12: 74.7: 8.44		RBM23_HUMAN (113-300): 2.1e-16: 83.6: 26.60
+	Hs
		516595 KMT2C_HUMAN (351-895): 4.49e-14: 79.7: 9.35		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64