Protein: CL12B
C-type lectin domain family 12 member B (Macrophage antigen H)

Gene: CL12B, CLEC12B
Organism: Homo sapiens
Interactions: 188
UniProt ID: Q2HXU8

Gene Ontology (top 5):
GO:0002769 - natural killer cell inhibitory signaling pathway
GO:0009897 - external side of plasma membrane
GO:0019903 - protein phosphatase binding
GO:0030246 - carbohydrate binding
GO:0030547 - signaling receptor inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1064059

MFGM
Lactadherin

2

12

High-throughput

0.776

High

603788

ITA2
Integrin alpha-2

1

4

High-throughput

0.691

High

719719

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

20

High-throughput

0.691

High

1105733

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

15

High-throughput

0.691

High

1177804

LRC24
Leucine-rich repeat-containing protein 24

1

16

High-throughput

0.691

High

1177819

R4RL2
Reticulon-4 receptor-like 2

1

9

High-throughput

0.691

High

270210

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.618

High

320874

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

11

High-throughput

0.618

High

931951

EPHB4
Ephrin type-B receptor 4

1

6

High-throughput

0.618

High

1177813

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

12

High-throughput

0.618

High

1177821

AMGO3
Amphoterin-induced protein 3

1

17

High-throughput

0.618

High

1177854

PTPRU
Receptor-type tyrosine-protein phosphatase U

1

5

High-throughput

0.618

High

1177861

LIGO1
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

1

13

High-throughput

0.618

High

1177865

LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

1

13

High-throughput

0.618

High

1177870

HPLN3
Hyaluronan and proteoglycan link protein 3

1

6

High-throughput

0.618

High

1177874

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

15

High-throughput

0.618

High

1177877

LRRC3
Leucine-rich repeat-containing protein 3

1

7

High-throughput

0.618

High

1177879

CNTP3
Contactin-associated protein-like 3

1

13

High-throughput

0.618

High

1177892

FPRP
Prostaglandin F2 receptor negative regulator

1

4

High-throughput

0.618

High

1177905

JAG2
Protein jagged-2

1

10

High-throughput

0.618

High

1031670

ILRL1
Interleukin-1 receptor-like 1

2

4

High-throughput

0.606

High

144432

SCD
Stearoyl-CoA desaturase

2

2

High-throughput

0.553

High

770858

OPRM
Mu-type opioid receptor

2

3

High-throughput

0.553

High

1030361

PMP22
Peripheral myelin protein 22

2

7

High-throughput

0.553

High

1092762

MALL
MAL-like protein

2

7

High-throughput

0.553

High

1177801

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

2

1

High-throughput

0.553

High

1177829

LSME2
Leucine-rich single-pass membrane protein 2

2

1

High-throughput

0.553

High

1177834

JAGN1
Protein jagunal homolog 1

2

2

High-throughput

0.553

High

1177864

SC22A
Vesicle-trafficking protein SEC22a

2

7

High-throughput

0.553

High

1177895

LPAR3
Lysophosphatidic acid receptor 3

2

9

High-throughput

0.553

High

1177906

PLLP
Plasmolipin

2

8

High-throughput

0.553

High

1177846

MSPD2
Motile sperm domain-containing protein 2

2

2

High-throughput

0.549

High

283689

GPC4
Glypican-4

1

6

High-throughput

0.536

High

335389

GDF11
Growth/differentiation factor 11

1

2

High-throughput

0.536

High

337532

LARG1
Xylosyl- and glucuronyltransferase LARGE1

1

6

High-throughput

0.536

High

363357

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.536

High

448033

ITAV
Integrin alpha-V

1

4

High-throughput

0.536

High

582383

B4GT1
Beta-1,4-galactosyltransferase 1

1

4

High-throughput

0.536

High

833467

WNT5A
Protein Wnt-5a

1

1

High-throughput

0.536

High

844200

ECE1
Endothelin-converting enzyme 1

1

4

High-throughput

0.536

High

885473

MA2A2
Alpha-mannosidase 2x

1

4

High-throughput

0.536

High

1083104

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

13

High-throughput

0.536

High

1089100

HYAL2
Hyaluronidase-2

1

2

High-throughput

0.536

High

1116711

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

4

High-throughput

0.536

High

1162127

MA2A1
Alpha-mannosidase 2

1

4

High-throughput

0.536

High

1177818

GALT7
N-acetylgalactosaminyltransferase 7

1

13

High-throughput

0.536

High

1177825

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

13

High-throughput

0.536

High

1177832

GLT16
Polypeptide N-acetylgalactosaminyltransferase 16

1

13

High-throughput

0.536

High

1177833

GALT4
Polypeptide N-acetylgalactosaminyltransferase 4

1

13

High-throughput

0.536

High

1177850

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

10

High-throughput

0.536

High

1177852

FAM3C
Protein FAM3C

1

9

High-throughput

0.536

High

1177872

CSTN3
Calsyntenin-3

1

4

High-throughput

0.536

High

1177897

CEIP2
Cell surface hyaluronidase CEMIP2

1

9

High-throughput

0.536

High

1120616

DAG1
Dystroglycan 1

1

0

High-throughput

0.513

High

49595

GXLT2
Glucoside xylosyltransferase 2

1

6

High-throughput

0.489

High

143738

WN10B
Protein Wnt-10b

1

1

High-throughput

0.489

High

160818

TOR1B
Torsin-1B

1

4

High-throughput

0.489

High

161040

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

High-throughput

0.489

High

175374

PLXB2
Plexin-B2

1

20

High-throughput

0.489

High

219812

CHSTA
Carbohydrate sulfotransferase 10

1

5

High-throughput

0.489

High

230793

EXTL3
Exostosin-like 3

1

5

High-throughput

0.489

High

250934

TPST1
Protein-tyrosine sulfotransferase 1

1

2

High-throughput

0.489

High

251089

B4GT3
Beta-1,4-galactosyltransferase 3

1

4

High-throughput

0.489

High

253845

TPST2
Protein-tyrosine sulfotransferase 2

1

2

High-throughput

0.489

High

269670

PLXA2
Plexin-A2

1

17

High-throughput

0.489

High

282589

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

1

High-throughput

0.489

High

320983

SUN1
SUN domain-containing protein 1

1

5

High-throughput

0.489

High

337260

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

1

9

High-throughput

0.489

High

341313

ECEL1
Endothelin-converting enzyme-like 1

1

4

High-throughput

0.489

High

343850

SEM4F
Semaphorin-4F

1

9

High-throughput

0.489

High

476500

STS
Steryl-sulfatase

1

2

High-throughput

0.489

High

488802

FURIN
Furin

1

2

High-throughput

0.489

High

560970

GP1BB
Platelet glycoprotein Ib beta chain

1

14

High-throughput

0.489

High

618190

AMD
Peptidyl-glycine alpha-amidating monooxygenase

1

1

High-throughput

0.489

High

648281

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

4

High-throughput

0.489

High

687105

MGAT1
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

1

4

High-throughput

0.489

High

755399

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

4

High-throughput

0.489

High

906283

GPC3
Glypican-3

1

6

High-throughput

0.489

High

907911

PLXA3
Plexin-A3

1

16

High-throughput

0.489

High

914846

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

1

1

High-throughput

0.489

High

914864

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.489

High

1010469

EREP3
Protein ENTREP3

1

3

High-throughput

0.489

High

1032589

AT2B2
Plasma membrane calcium-transporting ATPase 2

1

5

High-throughput

0.489

High

1038191

GCNT1
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase

1

2

High-throughput

0.489

High

1071246

TMM62
Transmembrane protein 62

1

1

High-throughput

0.489

High

1106162

TUSC3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3

1

2

High-throughput

0.489

High

1116867

MOGS
Mannosyl-oligosaccharide glucosidase

1

1

High-throughput

0.489

High

1125843

FZD2
Frizzled-2

1

4

High-throughput

0.489

High

1126017

GAS6
Growth arrest-specific protein 6

1

15

High-throughput

0.489

High

1131468

MBTP1
Membrane-bound transcription factor site-1 protease

1

2

High-throughput

0.489

High

1157357

EXT1
Exostosin-1

1

5

High-throughput

0.489

High

1164030

SIA4B
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

1

8

High-throughput

0.489

High

1164333

CGT
2-hydroxyacylsphingosine 1-beta-galactosyltransferase

1

3

High-throughput

0.489

High

1177800

UD3A2
UDP-glucuronosyltransferase 3A2

1

3

High-throughput

0.489

High

1177802

OFUT4
GDP-fucose protein O-fucosyltransferase 4

1

1

High-throughput

0.489

High

1177805

DIK1A
Divergent protein kinase domain 1A

1

5

High-throughput

0.489

High

1177806

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

1

1

High-throughput

0.489

High

1177807

DIK1B
Divergent protein kinase domain 1B

1

5

High-throughput

0.489

High

1177808

B4GN3
Beta-1,4-N-acetylgalactosaminyltransferase 3

1

4

High-throughput

0.489

High

1177812

ARSK
Arylsulfatase K

1

2

High-throughput

0.489

High

1177815

CHSS3
Chondroitin sulfate synthase 3

1

9

High-throughput

0.489

High

1177816

B4GN4
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 1

1

5

High-throughput

0.489

High

1177817

CHST3
Carbohydrate sulfotransferase 3

1

1

High-throughput

0.489

High

1177820

LRP11
Low-density lipoprotein receptor-related protein 11

1

5

High-throughput

0.489

High

1177822

CHSS1
Chondroitin sulfate synthase 1

1

9

High-throughput

0.489

High

1177827

K2013
Uncharacterized protein KIAA2013

1

2

High-throughput

0.489

High

1177828

K319L
Dyslexia-associated protein KIAA0319-like protein

1

3

High-throughput

0.489

High

1177830

GPC2
Glypican-2 [Cleaved into: Secreted glypican-2]

1

6

High-throughput

0.489

High

1177831

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

6

High-throughput

0.489

High

1177835

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

1

5

High-throughput

0.489

High

1177836

DCBD1
Discoidin, CUB and LCCL domain-containing protein 1

1

12

High-throughput

0.489

High

1177837

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.489

High

1177838

GOLM1
Golgi membrane protein 1

1

2

High-throughput

0.489

High

1177841

TTC13
Tetratricopeptide repeat protein 13

1

2

High-throughput

0.489

High

1177843

NETO2
Neuropilin and tolloid-like protein 2

1

7

High-throughput

0.489

High

1177844

CHSTE
Carbohydrate sulfotransferase 14

1

5

High-throughput

0.489

High

1177845

SIA7C
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3

1

8

High-throughput

0.489

High

1177847

PXYP1
2-phosphoxylose phosphatase 1

1

3

High-throughput

0.489

High

1177848

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

4

High-throughput

0.489

High

1177853

TM131
Transmembrane protein 131

1

2

High-throughput

0.489

High

1177855

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

8

High-throughput

0.489

High

1177856

SEM4D
Semaphorin-4D

1

9

High-throughput

0.489

High

1177857

NXPE3
NXPE family member 3

1

1

High-throughput

0.489

High

1177859

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

7

High-throughput

0.489

High

1177860

C1GLC
C1GALT1-specific chaperone 1

1

6

High-throughput

0.489

High

1177868

H6ST2
Heparan-sulfate 6-O-sulfotransferase 2

1

2

High-throughput

0.489

High

1177869

DCBD2
Discoidin, CUB and LCCL domain-containing protein 2

1

17

High-throughput

0.489

High

1177871

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

6

High-throughput

0.489

High

1177873

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.489

High

1177875

SFXN3
Sideroflexin-3

1

4

High-throughput

0.489

High

1177876

CHID1
Chitinase domain-containing protein 1

1

1

High-throughput

0.489

High

1177881

SEM6A
Semaphorin-6A

1

9

High-throughput

0.489

High

1177883

TOR3A
Torsin-3A

1

2

High-throughput

0.489

High

1177884

SIA7D
Alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase

1

8

High-throughput

0.489

High

1177885

S38AA
Solute carrier family 38 member 10

1

6

High-throughput

0.489

High

1177886

PGAP6
Post-GPI attachment to proteins factor 6

1

1

High-throughput

0.489

High

1177888

CHSTC
Carbohydrate sulfotransferase 12

1

5

High-throughput

0.489

High

1177889

CHST7
Carbohydrate sulfotransferase 7

1

1

High-throughput

0.489

High

1177890

EMIL3
EMILIN-3

1

10

High-throughput

0.489

High

1177891

IMPA3
Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase

1

1

High-throughput

0.489

High

1177893

CHPF2
Chondroitin sulfate glucuronyltransferase

1

8

High-throughput

0.489

High

1177898

PLXA1
Plexin-A1

1

16

High-throughput

0.489

High

1177899

POMT2
Protein O-mannosyl-transferase 2

1

2

High-throughput

0.489

High

1177901

CCPG1
Cell cycle progression protein 1

1

5

High-throughput

0.489

High

1177902

GRID1
Glutamate receptor ionotropic, delta-1

1

1

High-throughput

0.489

High

1177904

MINP1
Multiple inositol polyphosphate phosphatase 1

1

3

High-throughput

0.489

High

1177907

NALD2
N-acetylated-alpha-linked acidic dipeptidase 2

1

5

High-throughput

0.489

High

1177908

LRP12
Low-density lipoprotein receptor-related protein 12

1

11

High-throughput

0.489

High

1177909

GPC6
Glypican-6 [Cleaved into: Secreted glypican-6]

1

6

High-throughput

0.489

High

1177910

RFNG
Beta-1,3-N-acetylglucosaminyltransferase radical fringe

1

7

High-throughput

0.489

High

1177911

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.489

High

1177912

POMT1
Protein O-mannosyl-transferase 1

1

2

High-throughput

0.489

High

698710

CALX
Calnexin

1

20

High-throughput

0.445

High

1089955

LMAN2
Vesicular integral-membrane protein VIP36

1

7

High-throughput

0.445

High

170782

CLGN
Calmegin

1

20

High-throughput

0.407

High

1177862

RUSF1
RUS family member 1

1

2

High-throughput

0.407

High

1177880

LMA2L
VIP36-like protein

1

7

High-throughput

0.407

High

1177826

TM192
Transmembrane protein 192

2

0

High-throughput

0.313

High

1177851

PIEZ1
Piezo-type mechanosensitive ion channel component 1

2

0

High-throughput

0.313

High

322143

GLCE
D-glucuronyl C5-epimerase

1

0

High-throughput

0.279

Low

339267

MPC2
Mitochondrial pyruvate carrier 2

1

0

High-throughput

0.279

Low

895351

S26A2
Sulfate transporter

1

0

High-throughput

0.279

Low

1028102

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1160384

TAZ
Tafazzin

1

0

High-throughput

0.279

Low

1175799

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

1177799

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

1177803

ERFE
Erythroferrone

1

0

High-throughput

0.279

Low

1177809

MYORG
Myogenesis-regulating glycosidase

1

0

High-throughput

0.279

Low

1177810

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.279

Low

1177811

FIGL1
Fidgetin-like protein 1

1

0

High-throughput

0.279

Low

1177814

MIC27
MICOS complex subunit MIC27

1

0

High-throughput

0.279

Low

1177823

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.279

Low

1177824

GLBL2
Beta-galactosidase-1-like protein 2

1

0

High-throughput

0.279

Low

1177839

PGLT1
Protein O-glucosyltransferase 1

1

0

High-throughput

0.279

Low

1177840

PCYXL
Prenylcysteine oxidase 1-like

1

0

High-throughput

0.279

Low

1177842

P5I13
Tumor protein p53-inducible protein 13

1

0

High-throughput

0.279

Low

1177849

ABHD3
Phospholipase ABHD3

1

0

High-throughput

0.279

Low

1177858

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.279

Low

1177863

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

1177866

LMLN
Leishmanolysin-like peptidase

1

0

High-throughput

0.279

Low

1177867

NAR5
Ecto-ADP-ribosyltransferase 5

1

0

High-throughput

0.279

Low

1177878

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.279

Low

1177882

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

1177887

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

1177894

CATF
Cathepsin F

1

0

High-throughput

0.279

Low

1177896

GAK1A
Golgi-associated kinase 1A

1

0

High-throughput

0.279

Low

1177900

DSE
Dermatan-sulfate epimerase

1

0

High-throughput

0.279

Low

1177903

PPT2
Lysosomal thioesterase PPT2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025