Protein: NOD2
Nucleotide-binding oligomerization domain-containing protein 2 (Caspase recruitment domain-containing protein 15) (Inflammatory bowel disease protein 1)

Gene: NOD2
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q9HC29

Gene Ontology (top 5):
GO:0001659 - temperature homeostasis
GO:0002221 - pattern recognition receptor signaling pathway
GO:0002227 - innate immune response in mucosa
GO:0002250 - adaptive immune response
GO:0002606 - positive regulation of dendritic cell antigen processing and presentation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

201829

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

20

15

Small-scale

0.986

High

1301451

ERBIN
Erbin

5

20

Small-scale

0.925

High

957783

XIAP
E3 ubiquitin-protein ligase XIAP

3

9

Small-scale

0.857

High

1335688

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

3

17

Small-scale

0.821

High

667490

CASP1
Caspase-1

2

20

Small-scale

0.789

High

1335689

NLRC4
NLR family CARD domain-containing protein 4

2

17

Small-scale

0.776

High

1318559

NLRP1
NACHT, LRR and PYD domains-containing protein 1

2

19

Small-scale

0.770

High

1329053

CARD9
Caspase recruitment domain-containing protein 9

2

1

Small-scale

0.754

High

443822

VIME
Vimentin

3

8

Small-scale

0.686

High

1036917

SQSTM
Sequestosome-1

4

5

Small-scale

0.686

High

1290066

RNF31
E3 ubiquitin-protein ligase RNF31

4

3

Small-scale

0.686

High

201443

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

7

Small-scale

0.678

High

1146852

A16L1
Autophagy-related protein 16-1

3

4

Small-scale

0.662

High

1317085

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

3

7

Small-scale

0.656

High

1327698

SHRPN
Sharpin

3

1

Small-scale

0.656

High

1299030

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

18

Small-scale

0.653

High

49669

IRGM
Immunity-related GTPase family M protein

2

2

Small-scale

0.646

High

228758

PRKN
E3 ubiquitin-protein ligase parkin

1

11

Small-scale

0.618

High

830296

CASP4
Caspase-4

1

20

Small-scale

0.618

High

1036098

BIRC3
Baculoviral IAP repeat-containing protein 3

1

9

Small-scale

0.618

High

1036352

BIRC2
Baculoviral IAP repeat-containing protein 2

1

9

Small-scale

0.618

High

1038325

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

14

Small-scale

0.618

High

1082640

MK14
Mitogen-activated protein kinase 14

1

3

Small-scale

0.618

High

1166744

CASPC
Inactive caspase-12

1

20

Small-scale

0.618

High

1304519

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

2

Small-scale

0.618

High

1335698

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

18

Small-scale

0.618

High

1335699

CARD8
Caspase recruitment domain-containing protein 8

1

13

Small-scale

0.618

High

537077

TRI27
Zinc finger protein RFP

1

14

Small-scale

0.602

High

1335701

SGT1
Protein SGT1 homolog

2

13

Small-scale

0.601

High

1296171

SCYL1
N-terminal kinase-like protein

1

0

Small-scale

0.589

High

476411

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

Small-scale

0.575

High

980650

TLE1
Transducin-like enhancer protein 1

1

4

Small-scale

0.573

High

1219852

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

2

Small-scale

0.573

High

1261111

TRI41
E3 ubiquitin-protein ligase TRIM41

1

14

Small-scale

0.573

High

1335690

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

0

Small-scale

0.559

High

580107

K1C15
Keratin, type I cytoskeletal 15

1

8

Small-scale

0.552

High

320737

LDOC1
Protein LDOC1

1

0

Small-scale

0.549

High

1013955

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

Small-scale

0.549

High

1082542

2A5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

1

0

Small-scale

0.549

High

1273497

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.549

High

1335702

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.549

High

504785

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.536

High

624372

MYL9
Myosin regulatory light polypeptide 9

1

3

High-throughput

0.536

High

681608

DNJA1
DnaJ homolog subfamily A member 1

1

5

High-throughput

0.536

High

825258

RL34
Large ribosomal subunit protein eL34

1

1

High-throughput

0.536

High

833341

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.536

High

900274

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.536

High

959314

S25A3
Solute carrier family 25 member 3

1

3

High-throughput

0.536

High

1034809

TMED1
Transmembrane emp24 domain-containing protein 1

1

4

High-throughput

0.536

High

1313966

TMED9
Transmembrane emp24 domain-containing protein 9

1

2

High-throughput

0.536

High

1335697

CHIP
E3 ubiquitin-protein ligase CHIP

1

5

High-throughput

0.536

High

1335703

HDGR3
Hepatoma-derived growth factor-related protein 3

1

1

High-throughput

0.536

High

1318221

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

3

Small-scale

0.527

High

1335693

CHMP5
Charged multivesicular body protein 5

1

2

Small-scale

0.527

High

1335706

P2R3B
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta

1

1

Small-scale

0.527

High

321939

RIGI
Antiviral innate immune response receptor RIG-I

1

8

Small-scale

0.515

High

1184987

CSN6
COP9 signalosome complex subunit 6

1

2

Small-scale

0.515

High

316734

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.513

High

451564

CLCA
Clathrin light chain A

1

0

High-throughput

0.513

High

573487

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.513

High

672310

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

778295

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.513

High

927879

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

0

High-throughput

0.513

High

1014290

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.513

High

1016518

TWF1
Twinfilin-1

1

0

High-throughput

0.513

High

1335705

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.513

High

1223318

CJ067
Uncharacterized protein C10orf67, mitochondrial

1

0

Small-scale

0.504

High

669561

OAS2
2'-5'-oligoadenylate synthase 2

1

0

Small-scale

0.493

High

174152

SPTC1
Serine palmitoyltransferase 1

1

1

High-throughput

0.489

High

1335694

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

Small-scale

0.484

High

360435

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

11

Small-scale

0.481

High

419051

TPM3
Tropomyosin alpha-3 chain

1

2

Small-scale

0.481

High

427665

ANXA2
Annexin A2

1

2

Small-scale

0.481

High

451316

TPM1
Tropomyosin alpha-1 chain

1

2

Small-scale

0.481

High

456443

PPBI
Intestinal-type alkaline phosphatase

1

1

Small-scale

0.481

High

875335

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.481

High

932054

TPM4
Tropomyosin alpha-4 chain

1

2

Small-scale

0.481

High

1064166

TNIP1
TNFAIP3-interacting protein 1

1

4

Small-scale

0.481

High

1293397

PDLI5
PDZ and LIM domain protein 5

1

2

Small-scale

0.481

High

1330512

CHM4B
Charged multivesicular body protein 4b

1

2

Small-scale

0.481

High

1335707

TACC3
Transforming acidic coiled-coil-containing protein 3

1

1

Small-scale

0.481

High

453622

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

Small-scale

0.479

High

509987

VDR
Vitamin D3 receptor

1

4

Small-scale

0.479

High

599735

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

3

Small-scale

0.479

High

714077

HS71L
Heat shock 70 kDa protein 1-like

1

8

Small-scale

0.479

High

800079

VDAC2
Voltage-dependent anion-selective channel protein 2

1

1

High-throughput

0.479

High

879555

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.479

High

929067

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

978898

TF65
Transcription factor p65

1

1

Small-scale

0.479

High

1071843

TMED2
Transmembrane emp24 domain-containing protein 2

1

4

High-throughput

0.479

High

1135340

ATD3B
ATPase family AAA domain-containing protein 3B

1

10

Small-scale

0.479

High

1166177

OLFM4
Olfactomedin-4

1

3

Small-scale

0.479

High

1222103

S15A3
Solute carrier family 15 member 3

1

1

Small-scale

0.479

High

1223391

TRI22
E3 ubiquitin-protein ligase TRIM22

1

14

Small-scale

0.479

High

1235875

S15A4
Solute carrier family 15 member 4

1

1

Small-scale

0.479

High

1302993

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

Small-scale

0.479

High

1313362

TRAF4
TNF receptor-associated factor 4

1

10

Small-scale

0.479

High

1318854

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

Small-scale

0.479

High

1335692

ATD3A
ATPase family AAA domain-containing protein 3A

1

7

Small-scale

0.479

High

1335695

HSPB8
Heat shock protein beta-8

1

2

Small-scale

0.479

High

1335704

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

1335708

NEMO
NF-kappa-B essential modulator

1

3

Small-scale

0.479

High

1064307

ACAP1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1

1

2

Small-scale

0.462

High

773576

RL13A
Large ribosomal subunit protein uL13

1

0

Small-scale

0.460

High

869420

HAP1
Huntingtin-associated protein 1

1

0

Small-scale

0.460

High

1051469

DCTN1
Dynactin subunit 1

1

0

Small-scale

0.460

High

1059274

GOGB1
Golgin subfamily B member 1

1

0

Small-scale

0.460

High

1217027

LUR1L
Leucine rich adaptor protein 1-like

1

0

Small-scale

0.460

High

1305162

CCL13
C-C motif chemokine 13

1

0

Small-scale

0.460

High

1335700

WBP11
WW domain-binding protein 11

1

0

Small-scale

0.460

High

925634

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

Small-scale

0.458

High

1044886

AAMP
Angio-associated migratory cell protein

1

0

Small-scale

0.458

High

1335691

DUOX2
Dual oxidase 2

1

0

Small-scale

0.458

High

1335696

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.458

High

1204907

TRI50
E3 ubiquitin-protein ligase TRIM50

1

13

Small-scale

0.457

High

1318350

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

18

Small-scale

0.457

High

81638

B7Z6G4
cDNA FLJ53193, highly similar to Homo sapiens caldesmon 1

1

2

High-throughput

0.445

High

91439

E7EQ72
Transmembrane p24 trafficking protein 2

1

4

High-throughput

0.445

High

441678

MYL3
Myosin light chain 3

1

3

High-throughput

0.445

High

1127480

Q5JSD2
Voltage-dependent anion-selective channel protein 2

1

1

High-throughput

0.445

High

1298404

AP4AT
AP-4 complex accessory subunit Tepsin

1

0

Small-scale

0.426

High

1286538

ENTR1
Endosome-associated-trafficking regulator 1

1

0

Small-scale

0.299

High

1298524

DOCK7
Dedicator of cytokinesis protein 7

1

0

Small-scale

0.275

Low

1122637

LARGN
Protein Largen

1

0

Small-scale

0.251

Low

1174421

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

0

Small-scale

0.251

Low

1237818

NAT16
Probable N-acetyltransferase 16

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024