HitPredict

Interactor 1: WASL (O00401)
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)
Gene: WASL

Interactor 2: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.819

Property	Details
Experiments	35271311, 22847007
Identification Methods	affinity chromatography technology, pull down, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Actin~WH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 505 Hs			1 375
+	Hs
		133664 WASL_HUMAN (378-485): 2.87e-29: 122: 100.00		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		215916 SYNJ1_HUMAN (4-500): 4.16e-62: 222: 14.85		ACTC_HUMAN (2-375): 0: 594: 94.39
+	Hs
		590291 MUC1_HUMAN (125-417): 5.87e-09: 60.8: 8.19		ACTBL_HUMAN (2-375): 0: 734: 91.44
+	Hs
		133652 WASL_HUMAN (378-485): 2.87e-29: 122: 100.00		ACTB_HUMAN (1-375): 0: 604: 98.93
+	Hs
		133658 WASL_HUMAN (378-485): 2.87e-29: 122: 100.00		ACTC_HUMAN (2-375): 0: 594: 94.39
+	Mm
		993108 EP400_MOUSE (196-504): 1.78e-18: 91.3: 15.39		ACTG_MOUSE (1-375): 0: 604: 100.00
+	Sc
		948703 LAS17_YEAST (21-499): 3.51e-21: 99: 19.34		ACT_YEAST (1-375): 0: 592: 89.07
+	Hs
		590266 MUC1_HUMAN (125-417): 5.87e-09: 60.8: 8.19		ACTA_HUMAN (2-375): 0: 594: 94.39