Protein: WASL
Actin nucleation-promoting factor WASL (Neural Wiskott-Aldrich syndrome protein) (N-WASP)

Gene: WASL
Organism: Homo sapiens
Interactions: 105
UniProt ID: O00401

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

133608

WIPF1
WAS/WASL-interacting protein family member 1

8

17

Small-scale

0.978

High

133653

CDC42
Cell division control protein 42 homolog

7

20

Small-scale

0.959

High

133674

WIPF2
WAS/WASL-interacting protein family member 2

6

12

High-throughput

0.954

High

65436

WIPF3
WAS/WASL-interacting protein family member 3

4

13

High-throughput

0.911

High

133689

RHOJ
Rho-related GTP-binding protein RhoJ

4

20

High-throughput

0.903

High

133657

ACTG
Actin, cytoplasmic 2

2

8

Small-scale

0.819

High

133652

ACTB
Actin, cytoplasmic 1

2

8

High-throughput

0.789

High

133656

GRB2
Growth factor receptor-bound protein 2

11

20

Small-scale

0.760

High

133635

NCK1
SH2/SH3 adapter protein NCK1

7

20

Small-scale

0.746

High

133610

NCK2
Cytoplasmic protein NCK2

6

20

High-throughput

0.739

High

133654

ARP3
Actin-related protein 3

2

12

Small-scale

0.727

High

133655

ARP2
Actin-related protein 2

2

11

Small-scale

0.727

High

133613

RNF8
E3 ubiquitin-protein ligase RNF8

5

4

High-throughput

0.720

High

133618

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.715

High

133664

ACTBL
Beta-actin-like protein 2

1

8

High-throughput

0.691

High

133662

CIP4
Cdc42-interacting protein 4

4

20

Small-scale

0.687

High

133636

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

Small-scale

0.680

High

133628

PROF1
Profilin-1

3

5

Small-scale

0.676

High

133604

SDCB1
Syntenin-1

3

3

High-throughput

0.675

High

133607

ARPC3
Actin-related protein 2/3 complex subunit 3

3

4

High-throughput

0.675

High

133658

ACTC
Actin, alpha cardiac muscle 1

1

5

High-throughput

0.665

High

133670

RHG12
Rho GTPase-activating protein 12

3

4

High-throughput

0.665

High

133697

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

3

20

Small-scale

0.658

High

133698

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

3

20

Small-scale

0.658

High

133619

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.653

High

133611

VINEX
Vinexin

3

20

Small-scale

0.643

High

133687

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

3

20

Small-scale

0.641

High

133625

CHLE
Cholinesterase

2

1

High-throughput

0.628

High

133663

ITSN1
Intersectin-1

2

20

Small-scale

0.628

High

133661

SRC8
Src substrate cortactin

2

20

Small-scale

0.624

High

133700

SNX9
Sorting nexin-9

2

17

Small-scale

0.619

High

133621

RASN
GTPase NRas

1

13

High-throughput

0.618

High

133684

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.618

High

133699

BAIP2
BAR/IMD domain-containing adapter protein 2

2

20

High-throughput

0.614

High

133605

ARC1B
Actin-related protein 2/3 complex subunit 1B

2

12

Small-scale

0.611

High

133666

DNMBP
Dynamin-binding protein

2

20

Small-scale

0.611

High

133615

SRBS2
Sorbin and SH3 domain-containing protein 2

2

20

High-throughput

0.606

High

133649

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

20

High-throughput

0.606

High

133651

ARPC4
Actin-related protein 2/3 complex subunit 4

2

3

High-throughput

0.606

High

133673

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

20

High-throughput

0.606

High

133692

ABI2
Abl interactor 2

2

20

High-throughput

0.606

High

126907

APBB1
Amyloid beta precursor protein binding family B member 1

2

1

High-throughput

0.585

High

133660

PTK6
Protein-tyrosine kinase 6

1

20

High-throughput

0.573

High

133686

CIB1
Calcium and integrin-binding protein 1

1

0

Small-scale

0.561

High

133650

CORO7
Coronin-7

1

8

Small-scale

0.561

High

133624

LCK
Tyrosine-protein kinase Lck

1

20

Small-scale

0.550

High

133642

TNNT3
Troponin T, fast skeletal muscle

1

1

High-throughput

0.541

High

133683

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

9

High-throughput

0.541

High

133688

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

9

High-throughput

0.541

High

133627

PDIA1
Protein disulfide-isomerase

1

6

High-throughput

0.536

High

133691

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

7

High-throughput

0.536

High

133648

DSCR6
Protein ripply3

1

0

High-throughput

0.518

High

133643

ACY2
Aspartoacylase

1

0

High-throughput

0.513

High

133680

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

133603

BIN1
Myc box-dependent-interacting protein 1

1

20

Small-scale

0.501

High

133609

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

1

20

Small-scale

0.501

High

133612

PR40A
Pre-mRNA-processing factor 40 homolog A

1

20

High-throughput

0.501

High

133623

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

133629

HS90A
Heat shock protein HSP 90-alpha

1

11

Small-scale

0.501

High

133630

HS90B
Heat shock protein HSP 90-beta

1

11

Small-scale

0.501

High

133631

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.501

High

133665

FBP1L
Formin-binding protein 1-like

1

20

Small-scale

0.501

High

133685

FNBP1
Formin-binding protein 1

1

20

Small-scale

0.501

High

133696

ITBP2
Integrin beta-1-binding protein 2

1

2

High-throughput

0.494

High

133602

IPO5
Importin-5

1

3

High-throughput

0.481

High

133614

FCSD2
F-BAR and double SH3 domains protein 2

1

20

High-throughput

0.481

High

133620

HPT
Haptoglobin

1

2

High-throughput

0.481

High

133647

ANM2
Protein arginine N-methyltransferase 2

1

2

High-throughput

0.481

High

133669

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

20

High-throughput

0.481

High

133694

ITSN2
Intersectin-2

1

16

High-throughput

0.481

High

133640

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

Small-scale

0.480

High

133606

ARPC2
Actin-related protein 2/3 complex subunit 2

1

5

Small-scale

0.479

High

133617

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

7

High-throughput

0.479

High

133622

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

133633

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

133637

ITA2
Integrin alpha-2

1

5

Small-scale

0.479

High

133641

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

133644

CRK
Adapter molecule crk

1

20

Small-scale

0.479

High

133645

YAP1
Transcriptional coactivator YAP1

1

17

High-throughput

0.479

High

133646

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

High-throughput

0.479

High

133659

SQSTM
Sequestosome-1

1

7

High-throughput

0.479

High

133667

TRI67
Tripartite motif-containing protein 67

1

15

High-throughput

0.479

High

133668

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

133671

BICD2
Protein bicaudal D homolog 2

1

14

High-throughput

0.479

High

133679

SH3K1
SH3 domain-containing kinase-binding protein 1

1

20

High-throughput

0.479

High

133682

BICD1
Protein bicaudal D homolog 1

1

11

High-throughput

0.479

High

133693

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

133695

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

133701

DC1L1
Cytoplasmic dynein 1 light intermediate chain 1

1

2

High-throughput

0.479

High

133690

ZN395
Zinc finger protein 395

1

0

High-throughput

0.460

High

133639

EF1D
Elongation factor 1-delta

1

0

High-throughput

0.458

High

133675

ROBO4
Roundabout homolog 4

1

7

Small-scale

0.457

High

133634

CD44
CD44 antigen

1

2

Small-scale

0.445

High

133638

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

9

Small-scale

0.445

High

133676

OSTF1
Osteoclast-stimulating factor 1

1

20

High-throughput

0.439

High

104808

APRIO
Alternative prion protein

1

9

High-throughput

0.437

High

133626

GELS
Gelsolin

1

0

Small-scale

0.426

High

133672

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

3269

A0A0S2Z4D7
NCK adaptor protein 1 isoform 2

1

20

High-throughput

0.417

High

95921

E7ERP6
NCK adaptor protein 2

1

20

High-throughput

0.417

High

133616

FKBP9
Peptidyl-prolyl cis-trans isomerase FKBP9

1

2

High-throughput

0.407

High

133677

RN166
E3 ubiquitin-protein ligase RNF166

1

1

High-throughput

0.407

High

133681

ATG4C
Cysteine protease ATG4C

2

0

High-throughput

0.328

High

133632

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

133678

P33MX
Putative monooxygenase p33MONOX

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025