Protein: LAS17
Proline-rich protein LAS17

Gene: LAS17
Organism: Saccharomyces cerevisiae S288C
Interactions: 163
UniProt ID: Q12446

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005737 - cytoplasm
GO:0007015 - actin filament organization
GO:0030041 - actin filament polymerization
GO:0030479 - actin cortical patch

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

790593

VRP1
Verprolin

15

6

Small-scale

0.987

High

948703

ACT
Actin

11

8

Small-scale

0.978

High

736154

ARP2
Actin-related protein 2

11

11

Small-scale

0.977

High

865598

ARP3
Actin-related protein 3

7

12

Small-scale

0.957

High

1084920

LAS17
Proline-rich protein LAS17

4

8

Small-scale

0.887

High

814314

RV167
Reduced viability upon starvation protein 167

17

20

Small-scale

0.765

High

744949

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

15

7

Small-scale

0.764

High

805455

BZZ1
Protein BZZ1

9

20

Small-scale

0.760

High

850511

LSB3
LAS seventeen-binding protein 3

8

20

Small-scale

0.758

High

745064

YSC84
Protein YSC84

8

20

Small-scale

0.757

High

1046654

MYO5
Myosin-5

9

5

Small-scale

0.757

High

798174

ARPC1
Actin-related protein 2/3 complex subunit 1

7

11

Small-scale

0.744

High

1055186

PIN3
[PSI+] inducibility protein 3

6

20

Small-scale

0.738

High

779029

MYO3
Myosin-3

6

7

Small-scale

0.738

High

919312

LSB1
LAS seventeen-binding protein 1

5

20

Small-scale

0.725

High

864762

BBC1
Myosin tail region-interacting protein MTI1

5

7

Small-scale

0.718

High

818156

SHO1
High osmolarity signaling protein SHO1

4

1

Small-scale

0.703

High

751885

SLA2
Protein SLA2

4

5

High-throughput

0.700

High

809247

END3
Actin cytoskeleton-regulatory complex protein END3

4

10

High-throughput

0.700

High

922991

ARPC2
Actin-related protein 2/3 complex subunit 2

4

5

Small-scale

0.690

High

1052976

ARPC3
Actin-related protein 2/3 complex subunit 3

4

4

Small-scale

0.690

High

644861

CLH
Clathrin heavy chain

3

2

Small-scale

0.662

High

1050352

CYK2
Cytokinesis protein 2

3

20

Small-scale

0.660

High

672366

RV161
Reduced viability upon starvation protein 161

3

10

Small-scale

0.648

High

825857

ARPC5
Actin-related protein 2/3 complex subunit 5

3

2

Small-scale

0.636

High

673272

LSB5
LAS seventeen-binding protein 5

3

0

Small-scale

0.625

High

844719

LSB6
Phosphatidylinositol 4-kinase LSB6

3

0

Small-scale

0.615

High

678141

SYP1
Suppressor of yeast profilin deletion

2

4

Small-scale

0.614

High

750348

ARPC4
Actin-related protein 2/3 complex subunit 4

2

3

Small-scale

0.614

High

815619

RSP5
E3 ubiquitin-protein ligase RSP5

2

7

Small-scale

0.605

High

742735

HSP7F
Heat shock protein homolog SSE1

2

7

High-throughput

0.601

High

825442

PRK1
Actin-regulating kinase PRK1

2

4

Small-scale

0.595

High

592595

VATB
V-type proton ATPase subunit B

2

5

Small-scale

0.594

High

562975

CAPZB
F-actin-capping protein subunit beta

2

2

Small-scale

0.584

High

743368

FIMB
Fimbrin

2

3

Small-scale

0.584

High

918735

PIL1
Sphingolipid long chain base-responsive protein PIL1

2

1

Small-scale

0.584

High

510923

HSP77
Import motor subunit, mitochondrial

2

3

High-throughput

0.571

High

1084767

HSP42
Heat shock protein 42

2

0

Small-scale

0.569

High

458619

SEC4
Ras-related protein SEC4

1

5

Small-scale

0.549

High

481820

HSP73
Heat shock protein SSA3

1

4

Small-scale

0.536

High

738120

MYO4
Myosin-4

1

3

High-throughput

0.536

High

763269

SQT1
Ribosome assembly protein SQT1

1

4

High-throughput

0.536

High

803725

RPN1
26S proteasome regulatory subunit RPN1

1

3

High-throughput

0.536

High

711539

BEM1
Bud emergence protein 1

1

20

Small-scale

0.515

High

798434

RGD1
RHO GTPase-activating protein RGD1

1

5

High-throughput

0.508

High

1084923

ENT1
Epsin-1

1

2

High-throughput

0.508

High

646580

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.501

High

656919

KC12
Casein kinase I homolog 2

1

3

High-throughput

0.501

High

801966

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.501

High

453855

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.500

High

486364

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.500

High

486533

TBA3
Tubulin alpha-3 chain

1

3

High-throughput

0.500

High

676491

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.500

High

803387

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

18

High-throughput

0.494

High

1040610

COFI
Cofilin

1

0

Small-scale

0.493

High

560581

GAL2
Galactose transporter

1

2

High-throughput

0.489

High

609252

CLC1
Clathrin light chain

1

2

High-throughput

0.489

High

613516

ADT3
ADP,ATP carrier protein 3

1

2

High-throughput

0.489

High

671397

PHO84
Inorganic phosphate transporter PHO84

1

3

High-throughput

0.489

High

733833

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

1

High-throughput

0.489

High

808978

HXT6
High-affinity hexose transporter HXT6

1

2

High-throughput

0.489

High

809004

HXT7
High-affinity hexose transporter HXT7

1

2

High-throughput

0.489

High

923298

YN94
Uncharacterized membrane glycoprotein YNR065C

1

1

High-throughput

0.489

High

1044895

YHM2
Citrate/oxoglutarate carrier protein

1

1

High-throughput

0.489

High

386924

TBB
Tubulin beta chain

1

0

High-throughput

0.479

High

408370

GAL1
Galactokinase

1

0

High-throughput

0.479

High

416495

HXKA
Hexokinase-1

1

0

High-throughput

0.479

High

746322

UGPA1
UTP--glucose-1-phosphate uridylyltransferase

1

0

High-throughput

0.479

High

393561

HSP82
ATP-dependent molecular chaperone HSP82

1

11

Small-scale

0.479

High

449201

CALM
Calmodulin

1

9

Small-scale

0.479

High

580286

HSC82
ATP-dependent molecular chaperone HSC82

1

11

Small-scale

0.479

High

587344

ABP1
Actin-binding protein

1

20

Small-scale

0.479

High

654754

SPA2
Protein SPA2

1

7

Small-scale

0.479

High

687097

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

4

Small-scale

0.479

High

703787

CAPZA
F-actin-capping protein subunit alpha

1

1

Small-scale

0.479

High

738519

NUP2
Nucleoporin NUP2

1

4

Small-scale

0.479

High

739100

PAN1
Actin cytoskeleton-regulatory complex protein PAN1

1

13

Small-scale

0.479

High

741194

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

1

High-throughput

0.479

High

743430

TOR2
Serine/threonine-protein kinase TOR2

1

4

Small-scale

0.479

High

758351

HSL1
Probable serine/threonine-protein kinase HSL1

1

2

Small-scale

0.479

High

762884

TOR1
Serine/threonine-protein kinase TOR1

1

4

Small-scale

0.479

High

763512

MDJ1
DnaJ homolog 1, mitochondrial

1

3

Small-scale

0.479

High

763705

GCS1
ADP-ribosylation factor GTPase-activating protein GCS1

1

6

Small-scale

0.479

High

777226

KES1
Oxysterol-binding protein homolog 4

1

3

Small-scale

0.479

High

790381

STT4
Phosphatidylinositol 4-kinase STT4

1

1

Small-scale

0.479

High

797168

AIM3
Altered inheritance of mitochondria protein 3

1

7

Small-scale

0.479

High

806394

KOG1
Target of rapamycin complex 1 subunit KOG1

1

5

Small-scale

0.479

High

815782

SAP1
Protein SAP1

1

4

Small-scale

0.479

High

822476

TBP6
Probable 26S proteasome subunit YTA6

1

4

Small-scale

0.479

High

824705

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

2

Small-scale

0.479

High

825346

SLM1
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM1

1

1

Small-scale

0.479

High

850401

YFI6
Uncharacterized protein YFR016C

1

5

Small-scale

0.479

High

918598

TWF1
Twinfilin-1

1

1

Small-scale

0.479

High

919283

YG3A
Uncharacterized protein YGR130C

1

7

Small-scale

0.479

High

925301

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

1

Small-scale

0.479

High

1046241

SEG1
Eisosome protein SEG1

1

1

Small-scale

0.479

High

1048247

AVO2
Target of rapamycin complex 2 subunit AVO2

1

4

Small-scale

0.479

High

1050325

EIS1
Eisosome protein 1

1

3

Small-scale

0.479

High

1052328

ENT2
Epsin-2

1

7

High-throughput

0.479

High

1055172

CORO
Coronin-like protein

1

5

Small-scale

0.479

High

1065067

SCP1
Transgelin

1

3

Small-scale

0.479

High

1084651

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

1

Small-scale

0.479

High

793467

ATR
Serine/threonine-protein kinase MEC1

1

4

High-throughput

0.470

High

806019

LIN1
Protein LIN1

1

1

High-throughput

0.464

High

1084924

VPS5
Vacuolar protein sorting-associated protein 5

1

7

High-throughput

0.464

High

652907

TRX2
Thioredoxin-2

1

0

Small-scale

0.458

High

728722

ACBP
Acyl-CoA-binding protein

1

0

Small-scale

0.458

High

748106

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

797206

OPY1
Pleckstrin homology domain protein OPY1

1

0

Small-scale

0.458

High

797227

SHE3
SWI5-dependent HO expression protein 3

1

0

Small-scale

0.458

High

863192

YPP1
Cargo-transport protein YPP1

1

0

Small-scale

0.458

High

864409

BIT61
Target of rapamycin complex 2 subunit BIT61

1

0

Small-scale

0.458

High

919454

PBP1
PAB1-binding protein 1

1

0

Small-scale

0.458

High

924931

APP1
Phosphatidate phosphatase APP1

1

0

Small-scale

0.458

High

1055895

BSP1
F-actin capping regulator BSP1

1

0

Small-scale

0.458

High

1062804

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

Small-scale

0.458

High

1063932

CUE5
Ubiquitin-binding protein CUE5

1

0

Small-scale

0.458

High

1064625

AB140
tRNA(Thr)

1

0

Small-scale

0.458

High

735589

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

3

High-throughput

0.457

High

367158

ATPB
ATP synthase subunit beta, mitochondrial

1

5

High-throughput

0.457

High

453000

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.457

High

554981

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.457

High

613652

ADT2
ADP,ATP carrier protein 2

1

2

High-throughput

0.457

High

661703

MPCP
Mitochondrial phosphate carrier protein

1

1

High-throughput

0.457

High

740240

RPN2
26S proteasome regulatory subunit RPN2

1

2

High-throughput

0.457

High

525630

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

546844

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

577359

NSP1
Nucleoporin NSP1

1

3

Small-scale

0.437

High

708600

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

758493

SEG2
Eisosome protein SEG2

1

1

Small-scale

0.437

High

808742

ITS3
Phosphatidylinositol 4-phosphate 5-kinase MSS4

1

1

Small-scale

0.437

High

811442

CAJ1
Protein CAJ1

1

5

Small-scale

0.437

High

871865

SEC16
COPII coat assembly protein SEC16

1

1

Small-scale

0.437

High

917650

MLC1
Myosin light chain 1

1

6

Small-scale

0.437

High

1084443

YP150
Putative serine/threonine-protein kinase YPL150W

1

2

Small-scale

0.437

High

1084921

OSH2
Oxysterol-binding protein homolog 2

1

2

Small-scale

0.437

High

805808

NSG1
Protein NSG1

2

0

High-throughput

0.307

High

1084703

RBD2
Rhomboid-type serine protease 2

2

0

High-throughput

0.307

High

737997

KRE6
Beta-glucan synthesis-associated protein KRE6

1

0

Small-scale

0.305

High

1010282

PEX13
Peroxisomal membrane protein PEX13

1

0

High-throughput

0.296

High

735772

VA0D
V-type proton ATPase subunit d

1

0

High-throughput

0.279

Low

738349

RPN12
26S proteasome regulatory subunit RPN12

1

0

High-throughput

0.279

Low

626935

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.261

Low

1033911

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.261

Low

1084922

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.261

Low

561098

PCY1
Choline-phosphate cytidylyltransferase

1

0

Small-scale

0.249

Low

721121

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

0

Small-scale

0.249

Low

779457

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

Small-scale

0.249

Low

791995

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

Small-scale

0.249

Low

805741

NDT80
Meiosis-specific transcription factor NDT80

1

0

Small-scale

0.249

Low

817780

TSC11
Target of rapamycin complex 2 subunit TSC11

1

0

Small-scale

0.249

Low

864285

TAX4
Protein TAX4

1

0

Small-scale

0.249

Low

919658

YG5L
Uncharacterized protein YGR266W

1

0

Small-scale

0.249

Low

1043498

EFR3
Protein EFR3

1

0

Small-scale

0.249

Low

1043965

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

1049978

IVY1
Protein IVY1

1

0

Small-scale

0.249

Low

1052359

MSC3
Meiotic sister-chromatid recombination protein 3

1

0

Small-scale

0.249

Low

1052542

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

Small-scale

0.249

Low

1060652

VPS13
Intermembrane lipid transfer protein VPS13

1

0

Small-scale

0.249

Low

1065133

TCO89
Target of rapamycin complex 1 subunit TCO89

1

0

Small-scale

0.249

Low

1084406

PER33
Pore and endoplasmic reticulum protein of 33 kDa

1

0

High-throughput

0.249

Low

571858

SNA3
Protein SNA3

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025