HitPredict

Interactor 1: PJA1 (Q8NG27)
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)
Gene: PJA1

Interactor 2: SMC6 (Q96SB8)
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)
Gene: SMC6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.50	0.609

Property	Details
Experiments	30185588, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 643 Hs			1 1091
+	Hs
		1313276 PJA1_HUMAN (1-643): 2.66e-162: 481: 100.00		SMC5_HUMAN (5-1069): 4.07e-69: 254: 15.73
+	Hs
		923629 TTC3_HUMAN (29-635): 1e-85: 295: 12.34		SMC6_HUMAN (1-1091): 5.62e-114: 381: 100.00
+	Hs
		587595 TTC3_HUMAN (29-635): 1e-85: 295: 12.34		DESP_HUMAN (282-987): 4.88e-26: 118: 9.16
+	Hs
		587822 RNF12_HUMAN (1-641): 1e-52: 193: 12.73		DESP_HUMAN (282-987): 4.88e-26: 118: 9.16
+	Hs
		1414947 RN126_HUMAN (545-639): 7.45e-30: 121: 40.00		SMC3_HUMAN (127-1042): 6.74e-48: 188: 12.77
+	Hs
		773046 RNF12_HUMAN (1-641): 1e-52: 193: 12.73		MYH9_HUMAN (572-986): 3.44e-17: 89.7: 11.33
+	Hs
		1450914 RNF12_HUMAN (1-641): 1e-52: 193: 12.73		MYH2_HUMAN (500-964): 3.79e-17: 89.4: 8.13
+	Hs
		773289 RNF12_HUMAN (1-641): 1e-52: 193: 12.73		MYH10_HUMAN (115-543): 7.87e-14: 78.5: 10.62
+	Hs
		302360 RNF8_HUMAN (377-639): 8.53e-35: 139: 17.23		DESP_HUMAN (282-987): 4.88e-26: 118: 9.16