Protein: PJA1
E3 ubiquitin-protein ligase Praja-1 (Praja1) (EC 2.3.2.27) (RING finger protein 70) (RING-type E3 ubiquitin transferase Praja-1)

Gene: PJA1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q8NG27

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding
GO:0016567 - protein ubiquitination
GO:0030163 - protein catabolic process
GO:0061630 - ubiquitin protein ligase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

982252

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.865

High

1339816

PJA1
E3 ubiquitin-protein ligase Praja-1

3

16

Small-scale

0.845

High

957139

UB2D3
Ubiquitin-conjugating enzyme E2 D3

2

20

Small-scale

0.778

High

1339833

NSE3
Non-structural maintenance of chromosomes element 3 homolog

4

11

Small-scale

0.713

High

1339825

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

3

9

High-throughput

0.670

High

1339864

MAGD1
Melanoma-associated antigen D1

4

11

Small-scale

0.651

High

679375

DNJB2
DnaJ homolog subfamily B member 2

3

5

High-throughput

0.650

High

957630

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

20

Small-scale

0.647

High

995996

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

20

Small-scale

0.647

High

927072

ATX3
Ataxin-3

3

4

Small-scale

0.646

High

1313276

SMC5
Structural maintenance of chromosomes protein 5

2

6

High-throughput

0.628

High

1339852

DOCK5
Dedicator of cytokinesis protein 5

2

2

High-throughput

0.628

High

1218733

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.625

High

508302

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.618

High

1339840

RN126
E3 ubiquitin-protein ligase RNF126

1

11

High-throughput

0.618

High

1339828

FAF2
FAS-associated factor 2

3

13

High-throughput

0.609

High

1339829

AP2M1
AP-2 complex subunit mu

3

2

High-throughput

0.609

High

1339837

SMC6
Structural maintenance of chromosomes protein 6

3

9

Small-scale

0.609

High

1339827

SPSB4
SPRY domain-containing SOCS box protein 4

2

6

High-throughput

0.601

High

843787

HD
Huntingtin

2

1

Small-scale

0.584

High

1339826

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

Small-scale

0.579

High

1339821

HNRLL
Heterogeneous nuclear ribonucleoprotein L-like

2

4

High-throughput

0.574

High

1339832

MAGD4
Melanoma-associated antigen D4

2

11

High-throughput

0.574

High

1339843

LRC27
Leucine-rich repeat-containing protein 27

2

4

High-throughput

0.574

High

1339844

IQCN
IQ domain-containing protein N

2

1

High-throughput

0.574

High

1028822

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

10

Small-scale

0.561

High

1155561

EZH2
Histone-lysine N-methyltransferase EZH2

2

2

Small-scale

0.543

High

1339830

OTUB2
Ubiquitin thioesterase OTUB2

2

4

Small-scale

0.543

High

1115834

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

12

High-throughput

0.541

High

1132621

KIF22
Kinesin-like protein KIF22

1

2

High-throughput

0.541

High

1106213

MYO9B
Unconventional myosin-IXb

1

5

High-throughput

0.536

High

1326789

CBPA6
Carboxypeptidase A6

1

1

High-throughput

0.536

High

1339817

ARRD2
Arrestin domain-containing protein 2

1

5

High-throughput

0.536

High

1339820

SSH3
Protein phosphatase Slingshot homolog 3

1

2

High-throughput

0.536

High

1339842

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

1339847

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.536

High

905627

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.515

High

1014556

SMAD3
Mothers against decapentaplegic homolog 3

1

8

Small-scale

0.515

High

1339860

FBX10
F-box only protein 10

1

0

High-throughput

0.513

High

191924

MAGB4
Melanoma-associated antigen B4

1

11

Small-scale

0.501

High

583879

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

2

High-throughput

0.501

High

828227

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

4

High-throughput

0.501

High

853493

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

11

High-throughput

0.501

High

1005920

GTF2I
General transcription factor II-I

1

1

Small-scale

0.501

High

1025571

CDK16
Cyclin-dependent kinase 16

1

3

Small-scale

0.501

High

1258099

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

9

High-throughput

0.501

High

1339834

KCC1G
Calcium/calmodulin-dependent protein kinase type 1G

1

7

Small-scale

0.501

High

1339838

STAC
SH3 and cysteine-rich domain-containing protein

1

6

Small-scale

0.501

High

1339856

HOME2
Homer protein homolog 2

1

3

Small-scale

0.501

High

1339861

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

5

High-throughput

0.501

High

1339862

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

2

High-throughput

0.501

High

784664

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.494

High

1101856

SKP2
S-phase kinase-associated protein 2

1

3

High-throughput

0.489

High

1330812

TSYL6
Testis-specific Y-encoded-like protein 6

1

3

High-throughput

0.489

High

1339846

GHC2
Mitochondrial glutamate carrier 2

1

4

High-throughput

0.489

High

405514

KITH
Thymidine kinase, cytosolic

1

0

Small-scale

0.480

High

897056

MAP2
Methionine aminopeptidase 2

1

0

Small-scale

0.480

High

961194

FGF12
Fibroblast growth factor 12

1

0

Small-scale

0.480

High

1048320

LGUL
Lactoylglutathione lyase

1

0

Small-scale

0.480

High

1129558

ESPL1
Separin

1

0

High-throughput

0.480

High

1137404

SUZ12
Polycomb protein SUZ12

1

0

Small-scale

0.480

High

173103

XPO1
Exportin-1

1

3

High-throughput

0.479

High

211370

RFOX2
RNA binding protein fox-1 homolog 2

1

7

High-throughput

0.479

High

361309

SODC
Superoxide dismutase [Cu-Zn]

1

1

Small-scale

0.479

High

775212

FUS
RNA-binding protein FUS

1

9

Small-scale

0.479

High

783343

TRI23
E3 ubiquitin-protein ligase TRIM23

1

17

High-throughput

0.479

High

931199

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

1

1

High-throughput

0.479

High

1107943

SQSTM
Sequestosome-1

1

4

High-throughput

0.479

High

1162651

DGKD
Diacylglycerol kinase delta

1

2

Small-scale

0.479

High

1339620

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

1339824

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

8

Small-scale

0.479

High

1339850

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1339858

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

785847

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

Small-scale

0.458

High

791027

TALDO
Transaldolase

1

0

High-throughput

0.458

High

1290318

MORC1
MORC family CW-type zinc finger protein 1

1

0

High-throughput

0.458

High

209619

SERA
D-3-phosphoglycerate dehydrogenase

1

2

Small-scale

0.457

High

285374

EED
Polycomb protein EED

1

5

Small-scale

0.457

High

462523

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

Small-scale

0.457

High

1091862

ABR
Active breakpoint cluster region-related protein

1

2

Small-scale

0.457

High

1094311

LCP2
Lymphocyte cytosolic protein 2

1

2

Small-scale

0.457

High

1139179

JOS1
Josephin-1

1

4

High-throughput

0.457

High

1164316

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

1

2

Small-scale

0.457

High

1334105

TXND5
Thioredoxin domain-containing protein 5

1

6

Small-scale

0.457

High

1339819

DDX54
ATP-dependent RNA helicase DDX54

1

7

Small-scale

0.457

High

1339831

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.457

High

1339835

TSSK3
Testis-specific serine/threonine-protein kinase 3

1

2

Small-scale

0.457

High

1339836

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

13

High-throughput

0.457

High

1339848

ATX3L
Ataxin-3-like protein

1

4

High-throughput

0.457

High

1339859

NAGK
N-acetyl-D-glucosamine kinase

1

2

Small-scale

0.457

High

576469

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

4

High-throughput

0.457

High

1339839

SPSB2
SPRY domain-containing SOCS box protein 2

1

6

High-throughput

0.445

High

1315159

ZN440
Zinc finger protein 440

1

0

High-throughput

0.438

High

366424

FA12
Coagulation factor XII

1

2

High-throughput

0.437

High

675089

TNR6
Tumor necrosis factor receptor superfamily member 6

1

4

High-throughput

0.437

High

1096110

TADBP
TAR DNA-binding protein 43

1

7

Small-scale

0.437

High

1177973

MOONR
Protein moonraker

1

2

High-throughput

0.437

High

1178261

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

1249035

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

1339853

MYO10
Unconventional myosin-X

1

5

Small-scale

0.437

High

1243633

S27A1
Long-chain fatty acid transport protein 1

1

3

High-throughput

0.407

High

1334298

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

2

High-throughput

0.407

High

1339857

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

3

0

Small-scale

0.355

High

1339854

CHRC1
Chromatin accessibility complex protein 1

2

0

High-throughput

0.328

High

360204

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.282

High

1339845

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.282

High

1339849

RIBC2
RIB43A-like with coiled-coils protein 2

1

0

High-throughput

0.282

High

289363

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.279

Low

892979

ENTP1
Ectonucleoside triphosphate diphosphohydrolase 1

1

0

High-throughput

0.279

Low

1233767

CNDH2
Condensin-2 complex subunit H2

1

0

High-throughput

0.279

Low

340653

STABP
STAM-binding protein

1

0

High-throughput

0.261

Low

388863

A2GL
Leucine-rich alpha-2-glycoprotein

1

0

Small-scale

0.261

Low

425828

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

Small-scale

0.261

Low

1093482

COASY
Bifunctional coenzyme A synthase

1

0

Small-scale

0.261

Low

1159312

TAF9
Transcription initiation factor TFIID subunit 9

1

0

Small-scale

0.261

Low

1238657

TM214
Transmembrane protein 214

1

0

Small-scale

0.261

Low

1329586

NATD1
Protein NATD1

1

0

Small-scale

0.261

Low

1339818

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

Small-scale

0.261

Low

1339823

STAM1
Signal transducing adapter molecule 1

1

0

High-throughput

0.261

Low

1339851

RNZ1
Zinc phosphodiesterase ELAC protein 1

1

0

Small-scale

0.261

Low

1339863

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

Small-scale

0.261

Low

1326193

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.249

Low

1339822

ATLA1
Atlastin-1

1

0

Small-scale

0.249

Low

1339841

SFXN3
Sideroflexin-3

1

0

High-throughput

0.249

Low

1339855

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025