Protein: SMC6
Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6)

Gene: SMC6
Organism: Homo sapiens
Interactions: 88
UniProt ID: Q96SB8

Gene Ontology (top 5):
GO:0000217 - DNA secondary structure binding
GO:0000722 - telomere maintenance via recombination
GO:0000724 - double-strand break repair via homologous recombination
GO:0000775 - chromosome, centromeric region
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1313360

SMC5
Structural maintenance of chromosomes protein 5

8

17

Small-scale

0.970

High

1357653

NSE1
Non-structural maintenance of chromosomes element 1 homolog

7

3

Small-scale

0.966

High

1398156

NSE3
Non-structural maintenance of chromosomes element 3 homolog

6

9

Small-scale

0.736

High

1402677

NSE4A
Non-structural maintenance of chromosomes element 4 homolog A

5

11

Small-scale

0.723

High

1322859

EID3
EP300-interacting inhibitor of differentiation 3

5

11

Small-scale

0.716

High

1397722

ZN597
Zinc finger protein 597

4

3

High-throughput

0.691

High

1311919

SLF2
SMC5-SMC6 complex localization factor protein 2

3

1

Small-scale

0.683

High

1398147

NSE2
E3 SUMO-protein ligase NSE2

3

6

Small-scale

0.675

High

1402672

STN1
CST complex subunit STN1

3

1

High-throughput

0.667

High

1180068

PWP3A
PWWP domain-containing DNA repair factor 3A

3

0

High-throughput

0.646

High

1330825

TSYL6
Testis-specific Y-encoded-like protein 6

2

4

High-throughput

0.628

High

1336971

SIMC1
SUMO-interacting motif-containing protein 1

2

1

High-throughput

0.628

High

1402664

SMC6
Structural maintenance of chromosomes protein 6

1

16

Small-scale

0.618

High

1026516

HSF1
Heat shock factor protein 1

2

2

High-throughput

0.611

High

1088986

TP53B
TP53-binding protein 1

2

13

High-throughput

0.611

High

1339837

PJA1
E3 ubiquitin-protein ligase Praja-1

3

9

Small-scale

0.609

High

1402675

TUFT1
Tuftelin

3

2

High-throughput

0.609

High

998712

H31
Histone H3.1

2

19

High-throughput

0.584

High

246109

KIF1B
Kinesin-like protein KIF1B

1

12

High-throughput

0.536

High

630003

BTF3
Transcription factor BTF3

1

5

High-throughput

0.536

High

716609

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.536

High

807959

SMBP2
DNA-binding protein SMUBP-2

1

1

High-throughput

0.536

High

854244

KI67
Proliferation marker protein Ki-67

1

14

High-throughput

0.536

High

923629

TTC3
E3 ubiquitin-protein ligase TTC3

1

12

High-throughput

0.536

High

1015287

ERH
Enhancer of rudimentary homolog

1

1

High-throughput

0.536

High

1017588

ZBED6
Zinc finger BED domain-containing protein 6

1

1

High-throughput

0.536

High

1204445

ESCO1
N-acetyltransferase ESCO1

1

8

High-throughput

0.536

High

1244781

CC174
Coiled-coil domain-containing protein 174

1

1

High-throughput

0.536

High

1331957

ASCC1
Activating signal cointegrator 1 complex subunit 1

1

3

High-throughput

0.536

High

1361739

DGCR8
Microprocessor complex subunit DGCR8

1

1

High-throughput

0.536

High

1402665

SLF1
SMC5-SMC6 complex localization factor protein 1

1

17

High-throughput

0.536

High

1402666

IFT27
Intraflagellar transport protein 27 homolog

1

2

High-throughput

0.536

High

1402669

KLC2
Kinesin light chain 2

1

2

High-throughput

0.536

High

1402671

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.536

High

1402673

ELP3
Elongator complex protein 3

1

1

High-throughput

0.536

High

1402676

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.536

High

243708

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.515

High

1100638

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

1

High-throughput

0.515

High

1120300

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

14

High-throughput

0.515

High

869076

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.513

High

1402678

SPN90
NCK-interacting protein with SH3 domain

1

0

High-throughput

0.513

High

663826

LAMA2
Laminin subunit alpha-2

1

2

High-throughput

0.489

High

907932

PLXA3
Plexin-A3

1

3

High-throughput

0.489

High

1231781

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

2

High-throughput

0.489

High

1251327

B3GLT
Beta-1,3-glucosyltransferase

1

2

High-throughput

0.489

High

1402674

TM165
Putative divalent cation/proton antiporter TMEM165

1

1

High-throughput

0.489

High

129353

MEN1
Menin

1

5

High-throughput

0.479

High

260339

BRD4
Bromodomain-containing protein 4

1

17

High-throughput

0.479

High

412475

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.479

High

474229

NFIC
Nuclear factor 1 C-type

1

5

High-throughput

0.479

High

589474

RFA2
Replication protein A 32 kDa subunit

1

8

High-throughput

0.479

High

696284

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

714368

PML
Protein PML

1

20

High-throughput

0.479

High

768958

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.479

High

799420

BRCA1
Breast cancer type 1 susceptibility protein

1

16

High-throughput

0.479

High

1005003

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1017142

H33
Histone H3.3

1

19

High-throughput

0.479

High

1087964

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1107123

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1115015

CUL4A
Cullin-4A

1

16

High-throughput

0.479

High

1129708

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1133620

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1276678

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

1385605

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1402679

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1402683

ALK
ALK tyrosine kinase receptor

1

19

Small-scale

0.479

High

1402684

TIM
Protein timeless homolog

1

3

Small-scale

0.479

High

1402681

TNIK
TRAF2 and NCK-interacting protein kinase

1

14

High-throughput

0.457

High

372916

MYC
Myc proto-oncogene protein

1

18

High-throughput

0.445

High

414459

P53
Cellular tumor antigen p53

1

3

High-throughput

0.445

High

346219

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.437

High

1094474

IFT88
Intraflagellar transport protein 88 homolog

1

8

High-throughput

0.437

High

1255173

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.437

High

1339432

NBEA
Neurobeachin

1

9

High-throughput

0.437

High

1402670

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.437

High

1402682

HECD1
E3 ubiquitin-protein ligase HECTD1

1

11

High-throughput

0.437

High

1402687

SAR1B
Small COPII coat GTPase SAR1B

1

3

High-throughput

0.437

High

104298

F5H6C2
Intraflagellar transport 88

1

2

High-throughput

0.407

High

458932

HEXB
Beta-hexosaminidase subunit beta

1

0

High-throughput

0.279

Low

1120490

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.279

Low

1402667

MAK16
Protein MAK16 homolog

1

0

High-throughput

0.279

Low

1402668

T126A
Transmembrane protein 126A

1

0

High-throughput

0.279

Low

1402680

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

1402685

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.279

Low

1402686

IFT25
Intraflagellar transport protein 25 homolog

1

0

High-throughput

0.279

Low

1402688

CEPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.279

Low

339304

CV031
Uncharacterized protein C22orf31

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025