HitPredict

Interactor 1: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Interactor 2: LIMD1 (Q9UGP4)
LIM domain-containing protein 1
Gene: LIMD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	20303269, 32707033, 24255178
Identification Methods	affinity chromatography technology, proximity labelling technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0046872 - metal ion binding GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1088 Hs			1 676
+	Hs
		1080797 LATS2_HUMAN (1-1088): 0: 983: 100.00		ZYX_HUMAN (107-663): 6.52e-65: 226: 23.63
+	Hs
		1294456 LATS2_HUMAN (1-1088): 0: 983: 100.00		AJUBA_HUMAN (184-668): 3.37e-59: 210: 31.32
+	Hs
		325930 LATS1_HUMAN (1-1083): 0: 734: 49.61		LIMD1_HUMAN (1-676): 1.67e-124: 386: 100.00
+	Hs
		63213 LATS2_HUMAN (1-1088): 0: 983: 100.00		WTIP_HUMAN (526-671): 6.74e-17: 85.5: 24.34
+	Hs
		325748 LATS1_HUMAN (1-1083): 0: 734: 49.61		ZYX_HUMAN (107-663): 6.52e-65: 226: 23.63
+	Hs
		325852 LATS1_HUMAN (1-1083): 0: 734: 49.61		AJUBA_HUMAN (184-668): 3.37e-59: 210: 31.32
+	Hs
		63200 LATS1_HUMAN (1-1083): 0: 734: 49.61		WTIP_HUMAN (526-671): 6.74e-17: 85.5: 24.34
+	Hs
		325743 LATS1_HUMAN (1-1083): 0: 734: 49.61		TRIP6_HUMAN (102-601): 1.09e-12: 72.8: 15.29
+	Dm
		1360821 WARTS_DROME (167-1039): 7.21e-137: 443: 39.71		AJUBA_DROME (141-673): 2.08e-69: 242: 32.27
+	Dm
		1210946 WARTS_DROME (167-1039): 7.21e-137: 443: 39.71		Q8I0G8_DROME (536-671): 1.04e-22: 104: 27.34
+	Dm
		1341739 WARTS_DROME (167-1039): 7.21e-137: 443: 39.71		Q9N675_DROME (536-671): 5.11e-22: 102: 27.34
+	Hs
		969104 KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92		PDLI5_HUMAN (182-669): 4.19e-29: 124: 13.09
+	Mm
		554924 KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92		PDLI5_MOUSE (219-669): 2.8e-25: 112: 12.78
+	Rn
		448415 KPCE_RAT (554-1010): 2.62e-128: 410: 29.49		PDLI5_RAT (219-669): 2.84e-24: 109: 13.22
+	Hs
		67850 KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73		ZN724_HUMAN (286-415): 1.72e-19: 94.9: 5.39
+	Mm
		554947 KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92		LDB3_MOUSE (46-524): 3.3e-10: 65.4: 12.24
+	Hs
		823386 ROCK1_HUMAN (640-1008): 1.28e-70: 260: 38.77		PAXI_HUMAN (537-674): 1.04e-25: 114: 25.33
+	Ce
		107594 ROCK_CAEEL (653-1006): 1.47e-65: 243: 37.19		G5EFG1_CAEEL (533-669): 8.55e-24: 108: 20.86