HitPredict

Interactor 1: HIPPO (Q8T0S6)
Serine/threonine-protein kinase hippo (EC 2.7.11.1) (Drosophila homolog of MST1 and MST2) (STE20-like kinase MST) (dMST)
Gene: hpo

Interactor 2: Q9VCQ7 (Q9VCQ7)
LD40758p (Ras association family member)
Gene: Rassf

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	20797625, 24114784, 25484297, 17174922, 22215676, 32213597, 15710747, 38944040
Identification Methods	affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 669 Dm			1 806
+	Hs
		728442 AKT1_HUMAN (5-360): 4.63e-132: 399: 19.89		RASF1_HUMAN (557-801): 1.54e-82: 269: 20.78
+	Hs
		728350 AKT1_HUMAN (5-360): 4.63e-132: 399: 19.89		RASF5_HUMAN (555-801): 9.2e-68: 232: 20.97
+	Hs
		1096437 PAK1_HUMAN (2-317): 1.59e-115: 358: 35.85		LASP1_HUMAN (2-188): 2.88e-44: 162: 18.04
+	Hs
		1096513 PAK1_HUMAN (2-317): 1.59e-115: 358: 35.85		LIMA1_HUMAN (3-138): 1.59e-29: 127: 23.13
+	Hs
		897634 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF2_HUMAN (550-802): 5.62e-105: 327: 31.42
+	Hs
		897635 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF2_HUMAN (550-802): 5.62e-105: 327: 31.42
+	Hs
		1093130 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF6_HUMAN (550-801): 4.29e-98: 311: 29.55
+	Hs
		1097690 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF6_HUMAN (550-801): 4.29e-98: 311: 29.55
+	Hs
		1093176 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF4_HUMAN (550-802): 8.65e-87: 279: 32.30
+	Hs
		1097735 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF4_HUMAN (550-802): 8.65e-87: 279: 32.30
+	Hs
		1093192 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF1_HUMAN (557-801): 1.54e-82: 269: 20.78
+	Hs
		1097750 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF1_HUMAN (557-801): 1.54e-82: 269: 20.78
+	Hs
		1093142 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF3_HUMAN (524-802): 8.13e-79: 255: 18.44
+	Hs
		1097699 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF3_HUMAN (524-802): 8.13e-79: 255: 18.44
+	Mm
		1204188 STK4_MOUSE (543-661): 2.85e-17: 87: 29.03		RASF5_MOUSE (555-801): 7.47e-71: 240: 23.86
+	Hs
		1093150 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		RASF5_HUMAN (555-801): 9.2e-68: 232: 20.97
+	Hs
		1097712 STK3_HUMAN (399-661): 1.31e-16: 85.2: 16.85		RASF5_HUMAN (555-801): 9.2e-68: 232: 20.97
+	Hs
		1093113 STK4_HUMAN (547-661): 1.38e-17: 88.2: 31.30		CSRP2_HUMAN (3-184): 3.58e-38: 142: 18.18