HitPredict

Interactor 1: EHD2 (Q9NZN4)
EH domain-containing protein 2 (PAST homolog 2)
Gene: EHD2

Interactor 2: EPN1 (Q9Y6I3)
Epsin-1 (EH domain-binding mitotic phosphoprotein) (EPS-15-interacting protein 1)
Gene: EPN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21115825
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006897 - endocytosis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 576
+	Mm
		1194350 EHD2_MOUSE (1-543): 0: 837: 96.69		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		1331796 EHD1_HUMAN (1-538): 0: 820: 70.63		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Mm
		1194352 EHD1_MOUSE (1-538): 0: 819: 70.26		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		1328941 EHD2_HUMAN (1-543): 0: 838: 100.00		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Ce
		1259347 Q8WSP1_CAEEL (1-540): 0: 791: 60.15		Q9BI72_CAEEL (1-477): 2.39e-73: 243: 32.72
+	Mm
		1206518 EHD2_MOUSE (1-543): 0: 837: 96.69		EPN3_MOUSE (1-571): 2.38e-50: 185: 37.05
+	Hs
		1328938 EHD1_HUMAN (1-538): 0: 820: 70.63		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Mm
		1265097 EHD1_MOUSE (1-538): 0: 819: 70.26		EPN3_MOUSE (1-571): 2.38e-50: 185: 37.05
+	Hs
		1244792 REPS2_HUMAN (398-532): 1.26e-34: 140: 31.39		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Mm
		1194353 ITSN1_MOUSE (444-532): 3.01e-27: 118: 36.67		EPN1_MOUSE (1-576): 1.93e-88: 286: 94.44
+	Hs
		787913 EPS15_HUMAN (451-541): 3.38e-13: 74.7: 26.09		EPN4_HUMAN (3-561): 1.44e-89: 290: 24.14
+	Hs
		787997 EPS15_HUMAN (451-541): 3.38e-13: 74.7: 26.09		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		1353935 EP15R_HUMAN (453-541): 3.2e-09: 61.6: 27.78		EPN1_HUMAN (1-576): 4.42e-90: 290: 100.00
+	Hs
		307533 ITSN1_HUMAN (444-532): 7.23e-28: 120: 36.67		EPN2_HUMAN (1-566): 6.51e-54: 195: 38.02
+	Sc
		692257 PAN1_YEAST (381-528): 2.88e-17: 87.8: 23.49		ENT1_YEAST (3-228): 6.81e-62: 212: 36.73
+	Sc
		692249 PAN1_YEAST (381-528): 2.88e-17: 87.8: 23.49		ENT2_YEAST (3-538): 7.67e-59: 208: 19.59
+	Hs
		787969 EPS15_HUMAN (451-541): 3.38e-13: 74.7: 26.09		EPN3_HUMAN (1-571): 3.16e-55: 199: 40.16
+	Hs
		203228 ITSN1_HUMAN (444-532): 7.23e-28: 120: 36.67		SYNJ1_HUMAN (246-573): 8.14e-20: 96.3: 14.11
+	Rn
		1126747 Q5JC29_RAT (451-541): 4.49e-12: 70.8: 25.00		SYNJ1_RAT (246-575): 3.51e-15: 81.2: 14.67