HitPredict

Interactor 1: UBE2C (O00762)
Ubiquitin-conjugating enzyme E2 C (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme C) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme C) (UbcH10) (Ubiquitin carrier protein C) (Ubiquitin-protein ligase C)
Gene: UBE2C

Interactor 2: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	27182664, 34642328, 16196087
Identification Methods	proximity labelling technology, pull down, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 179 Hs			1 685
+	Hs
		475586 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476604 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475501 UB2D1_HUMAN (31-176): 2.07e-79: 234: 36.30		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		476218 UB2E2_HUMAN (2-175): 2.69e-78: 233: 33.52		UBC_HUMAN (1-685): 0: 846: 100.00
+	Hs
		475550 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		UBC_HUMAN (1-685): 0: 846: 100.00
+	Xl
		919927 UB2D2_XENLA (31-176): 3.22e-80: 236: 34.93		Q7SY79_XENLA (77-685): 0: 744: 99.84
+	Dm
		639414 UBCD1_DROME (31-176): 7.64e-79: 232: 36.30		Q9W418_DROME (229-685): 0: 557: 99.78
+	At
		1091932 UBC28_ARATH (31-177): 1.09e-79: 235: 35.37		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		715116 UBC8_ARATH (31-177): 2.91e-79: 233: 35.37		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		715132 UBC9_ARATH (31-177): 1.82e-78: 232: 34.69		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		715147 UBC10_ARATH (31-177): 2.34e-78: 231: 34.01		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	At
		715157 UBC11_ARATH (31-177): 2.75e-78: 231: 35.37		UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63
+	Hs
		895773 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		RS27A_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Hs
		70479 UB2E3_HUMAN (6-175): 6.95e-77: 230: 34.71		B2RDW1_HUMAN (609-684): 7.23e-41: 148: 100.00
+	Rn
		88580 UB2D1_RAT (31-176): 2.07e-79: 234: 36.30		UBC_RAT (1-108): 1.27e-29: 127: 90.74
+	Mm
		476737 UB2D3_MOUSE (31-176): 2.12e-78: 231: 34.93		UBC_MOUSE (1-108): 9.43e-30: 127: 90.74
+	Hs
		171490 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBD_HUMAN (155-304): 5.41e-28: 112: 32.05
+	Hs
		397879 UB2D3_HUMAN (31-176): 2.12e-78: 231: 34.93		ISG15_HUMAN (228-380): 1.72e-28: 113: 32.69
+	Hs
		474984 UB2D2_HUMAN (31-176): 3.22e-80: 236: 34.93		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70
+	Hs
		475249 UB2D4_HUMAN (31-176): 1.99e-80: 236: 37.67		UBB_HUMAN (1-77): 7.83e-26: 108: 98.70