Protein: VPS34
Phosphatidylinositol 3-kinase VPS34 (PI3-kinase VPS34) (PI3K VPS34) (PtdIns-3-kinase VPS34) (EC 2.7.1.137) (Carboxypeptidase Y-deficient protein 15) (Vacuolar protein sorting-associated protein 34) (Vacuolar protein-targeting protein 29)

Gene: VPS34
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P22543

Gene Ontology (top 5):
GO:0000045 - autophagosome assembly
GO:0000139 - Golgi membrane
GO:0000329 - fungal-type vacuole membrane
GO:0000407 - phagophore assembly site
GO:0000425 - pexophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

646630

VPS15
Serine/threonine-protein kinase VPS15

7

12

Small-scale

0.968

High

649848

BECN1
Vacuolar protein sorting-associated protein 30

8

8

Small-scale

0.751

High

649819

ATG14
Autophagy-related protein 14

8

0

Small-scale

0.714

High

649856

VPS38
Vacuolar protein sorting-associated protein 38

6

0

Small-scale

0.701

High

649855

ATG38
PtdIns3K complex I subunit atg38

3

0

Small-scale

0.643

High

376270

YPT1
GTP-binding protein YPT1

1

10

High-throughput

0.618

High

458535

SEC4
Ras-related protein SEC4

1

11

High-throughput

0.618

High

649793

VPS34
Phosphatidylinositol 3-kinase VPS34

1

13

High-throughput

0.618

High

649808

YPT7
Ypt/Rab-type GTPase YPT7

1

11

High-throughput

0.618

High

649812

VPS21
Vacuolar protein sorting-associated protein 21

1

20

High-throughput

0.618

High

649813

YPT52
GTP-binding protein YPT52

1

19

High-throughput

0.618

High

649823

YPT31
GTP-binding protein YPT31/YPT8

1

13

High-throughput

0.618

High

649837

YPT32
GTP-binding protein YPT32/YPT11

1

13

High-throughput

0.618

High

649839

ATG1
Serine/threonine-protein kinase ATG1

2

7

Small-scale

0.602

High

649857

ATG9
Autophagy-related protein 9

2

1

High-throughput

0.584

High

470737

GPA1
Guanine nucleotide-binding protein alpha-1 subunit

1

4

Small-scale

0.578

High

649810

PP2C3
Protein phosphatase 2C homolog 3

1

0

High-throughput

0.493

High

649828

VPS8
Vacuolar protein sorting-associated protein 8

1

0

Small-scale

0.493

High

649847

ATG21
Autophagy-related protein 21

1

1

Small-scale

0.481

High

564704

ATC1
Calcium-transporting ATPase 1

1

2

High-throughput

0.479

High

578870

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

582416

SEC23
Protein transport protein SEC23

1

1

High-throughput

0.479

High

616385

SEC18
Vesicular-fusion protein SEC18

1

8

High-throughput

0.479

High

633529

SAR1
Small COPII coat GTPase SAR1

1

12

High-throughput

0.479

High

644715

CLH
Clathrin heavy chain

1

5

High-throughput

0.479

High

646173

SLY1
Protein SLY1

1

1

High-throughput

0.479

High

649794

BET1
Protein transport protein BET1

1

2

High-throughput

0.479

High

649795

KC11
Casein kinase I homolog 1

1

11

High-throughput

0.479

High

649797

CDC48
Cell division control protein 48

1

6

High-throughput

0.479

High

649798

PEP3
Vacuolar membrane protein PEP3

1

3

High-throughput

0.479

High

649800

COPG
Coatomer subunit gamma

1

2

High-throughput

0.479

High

649801

VPS10
Vacuolar protein sorting/targeting protein VPS10

1

2

High-throughput

0.479

High

649805

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

649806

PEP12
Syntaxin PEP12

1

1

High-throughput

0.479

High

649807

SSO1
Protein SSO1

1

1

High-throughput

0.479

High

649809

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

649811

CASP
Protein CASP

1

10

High-throughput

0.479

High

649814

VPS24
Vacuolar protein-sorting-associated protein 24

1

2

High-throughput

0.479

High

649815

DID4
DOA4-independent degradation protein 4

1

2

High-throughput

0.479

High

649821

SDS24
Protein SDS24

1

1

High-throughput

0.479

High

649825

GOSR1
Golgi SNAP receptor complex member 1

1

2

High-throughput

0.479

High

649827

AKR1
Palmitoyltransferase AKR1

1

4

High-throughput

0.479

High

649829

SNF7
Vacuolar-sorting protein SNF7

1

3

High-throughput

0.479

High

649831

KC13
Casein kinase I homolog 3

1

17

High-throughput

0.479

High

649832

VAC8
Vacuolar protein 8

1

6

High-throughput

0.479

High

649834

ATC7
Phospholipid-transporting ATPase NEO1

1

1

High-throughput

0.479

High

649844

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.479

High

649845

DID2
Vacuolar protein-sorting-associated protein 46

1

2

High-throughput

0.479

High

649846

SED5
Integral membrane protein SED5

1

2

High-throughput

0.479

High

649849

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

3

High-throughput

0.479

High

649851

PDS5
Sister chromatid cohesion protein PDS5

1

1

High-throughput

0.479

High

649858

VAM3
Syntaxin VAM3

1

2

High-throughput

0.479

High

649859

NYV1
Vacuolar v-SNARE NYV1

1

1

High-throughput

0.479

High

556588

PEP5
E3 ubiquitin-protein ligase PEP5

1

0

High-throughput

0.458

High

638972

VPS1
Vacuolar protein sorting-associated protein 1

1

0

High-throughput

0.458

High

646212

SEC22
Protein transport protein SEC22

1

0

High-throughput

0.458

High

649796

BOS1
Protein transport protein BOS1

1

0

High-throughput

0.458

High

649804

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.458

High

649816

TVP38
Golgi apparatus membrane protein TVP38

1

0

High-throughput

0.458

High

649817

VPP2
V-type proton ATPase subunit a, Golgi isoform

1

0

High-throughput

0.458

High

649818

SFT2
Protein transport protein SFT2

1

0

High-throughput

0.458

High

649820

FTH1
Iron transporter FTH1

1

0

High-throughput

0.458

High

649826

SVP26
Protein SVP26

1

0

High-throughput

0.458

High

649830

SS120
Protein SSP120

1

0

High-throughput

0.458

High

649835

EMP47
Protein EMP47

1

0

High-throughput

0.458

High

649836

SFT1
Protein transport protein SFT1

1

0

High-throughput

0.458

High

649838

YIP1
Protein transport protein YIP1

1

0

High-throughput

0.458

High

649841

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

649842

PRA1
Prenylated Rab acceptor 1

1

0

High-throughput

0.458

High

649843

YIF1
Protein transport protein YIF1

1

0

High-throughput

0.458

High

649850

RCR2
Protein RCR2

1

0

High-throughput

0.458

High

649852

VTI1
t-SNARE VTI1

1

0

High-throughput

0.458

High

649853

ERV41
ER-derived vesicles protein ERV41

1

0

High-throughput

0.458

High

649860

YOP1
Protein YOP1

1

0

High-throughput

0.458

High

649861

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.458

High

523091

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

649803

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

649833

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

649799

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

649802

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.437

High

649854

ERP1
Protein ERP1

1

2

High-throughput

0.437

High

506431

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

649822

PHO89
Phosphate permease PHO89

1

0

High-throughput

0.249

Low

649824

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.249

Low

649840

PRM8
Pheromone-regulated membrane protein 8

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025