HitPredict

Interactor 1: ZNRF4 (Q8WWF5)
E3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
Gene: ZNRF4

Interactor 2: S12A6 (Q9UHW9)
Solute carrier family 12 member 6 (Electroneutral potassium-chloride cotransporter 3) (K-Cl cotransporter 3)
Gene: SLC12A6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.50	0.574

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 429 Hs			1 1150
+	Hs
		1359381 ZNRF4_HUMAN (1-429): 3.2e-135: 396: 100.00		S12A7_HUMAN (71-1150): 0: 1058: 69.37
+	Hs
		933446 RN149_HUMAN (95-390): 2.57e-64: 213: 18.61		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Hs
		933421 RNF43_HUMAN (116-427): 2.03e-45: 169: 17.42		S12A2_HUMAN (4-1150): 0: 715: 19.37
+	Hs
		912699 RN128_HUMAN (83-411): 1.14e-59: 202: 17.55		CTR2_HUMAN (229-668): 1.63e-93: 315: 15.46
+	Hs
		722540 RN149_HUMAN (95-390): 2.57e-64: 213: 18.61		CTR1_HUMAN (231-668): 7.06e-88: 299: 13.67
+	Hs
		1031821 RN149_HUMAN (95-390): 2.57e-64: 213: 18.61		LAT1_HUMAN (228-752): 4.38e-80: 273: 11.45
+	Hs
		1031865 RN122_HUMAN (233-371): 2.44e-25: 102: 19.42		LAT1_HUMAN (228-752): 4.38e-80: 273: 11.45