Interactor 1: C1TC (Q922D8)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: Mthfd1
Interactor 2: C1TC (Q922D8)
C-1-tetrahydrofolate synthase, cytoplasmic (C1-THF synthase) [Cleaved into: C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed] [Includes: Methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9); Formyltetrahydrofolate synthetase (EC 6.3.4.3)]
Gene: Mthfd1
Species: Mus musculus
Source: biogrid
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.38 | 1.00 | 0.618 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 28130547 |
| Identification Methods | cross-linking study |
| Interaction Type | physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | FTHFS~FTHFS, THF_DHG_CYH~THF_DHG_CYH, THF_DHG_CYH~THF_DHG_CYH_C, THF_DHG_CYH_C~THF_DHG_CYH_C |
| Common GO terms | GO:0000105 - L-histidine biosynthetic process GO:0001780 - neutrophil homeostasis GO:0001843 - neural tube closure GO:0004329 - formate-tetrahydrofolate ligase activity GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity and 15 others more... |
| Homologous interactions | 6 |
Homologous interactions
Color coding for hit scores 
|
|
|||||||||||||
| + | Sc |   |
|
|||||||||||
| + | Sc | |
|
|||||||||||
| + | Cj | |
|
|||||||||||
| + | Hs | |
|
|||||||||||
| + | Sc | |
|
|||||||||||
| + | Sp | |
|
|||||||||||
Service provided by Combinatics, Japan
Last updated: 11Aug2025
