Protein: MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)]

Gene: MTD2L, MTHFD2L
Organism: Homo sapiens
Interactions: 17
UniProt ID: Q9H903

Gene Ontology (top 5):
GO:0004477 - methenyltetrahydrofolate cyclohydrolase activity
GO:0004487 - methylenetetrahydrofolate dehydrogenase (NAD+) activity
GO:0004488 - methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

569337

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

2

6

High-throughput

0.811

High

1412498

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

2

0

High-throughput

0.585

High

884234

SRP09
Signal recognition particle 9 kDa protein

2

1

High-throughput

0.574

High

1287735

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

879756

MAPK2
MAP kinase-activated protein kinase 2

1

1

High-throughput

0.489

High

1356541

RAB2B
Ras-related protein Rab-2B

1

2

High-throughput

0.489

High

1431044

RNAS7
Ribonuclease 7

1

1

High-throughput

0.489

High

1436741

ZHX2
Zinc fingers and homeoboxes protein 2

1

1

High-throughput

0.489

High

521947

H14
Histone H1.4

1

1

High-throughput

0.437

High

1214626

HENMT
Small RNA 2'-O-methyltransferase

2

0

High-throughput

0.328

High

1292673

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

1392914

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

219232

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.279

Low

1279824

BTLA
B- and T-lymphocyte attenuator

1

0

High-throughput

0.279

Low

1387800

MUCL1
Mucin-like protein 1

1

0

High-throughput

0.279

Low

1436740

MTL5
Tesmin

1

0

High-throughput

0.279

Low

370116

CYTS
Cystatin-S

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025