HitPredict

Interactor 1: IKKB (Q9VEZ5)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappaB kinase subunit beta) (EC 2.7.11.10) (Cactus kinase IKK) (IKK-like protein) (Immune response deficient protein 5) (Lipopolysaccharide-activated kinase) (DLAK)
Gene: IKKbeta

Interactor 2: IKKB (Q9VEZ5)
Inhibitor of nuclear factor kappa-B kinase subunit beta (I-kappaB kinase subunit beta) (EC 2.7.11.10) (Cactus kinase IKK) (IKK-like protein) (Immune response deficient protein 5) (Lipopolysaccharide-activated kinase) (DLAK)
Gene: IKKbeta

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 23749869, 19497884, 10636911
Identification Methods affinity chromatography technology, protein kinase assay, in-gel kinase assay
Interaction Type physical association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0002230 - positive regulation of defense response to virus by host
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 14 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 751
Dm

1 751
+ Hs
+ At
+ Hs
+ At
+ Gm
+ Mm
+ At
+ At
+ At
+ Zm
+ Mm
+ At
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs

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Last updated: 15 Jul 2024