HitPredict

Interactor 1: FAF2 (Q96CS3)
FAS-associated factor 2 (UBX domain-containing protein 3B) (UBX domain-containing protein 8)
Gene: FAF2

Interactor 2: DERL2 (Q9GZP9)
Derlin-2 (Degradation in endoplasmic reticulum protein 2) (DERtrin-2) (Der1-like protein 2) (F-LAN-1) (F-LANa)
Gene: DERL2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	22119785, 26186194, 26389662, 28514442, 33961781, 21909096, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005783 - endoplasmic reticulum GO:0030970 - retrograde protein transport, ER to cytosol GO:0036503 - ERAD pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 445 Hs			1 239
+	Hs
		1386347 FAF2_HUMAN (1-445): 1.33e-143: 419: 100.00		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15
+	Sc
		1046152 UBX2_YEAST (9-430): 9.08e-66: 222: 16.38		DFM1_YEAST (7-238): 2.3e-53: 177: 23.16
+	Hs
		1365053 UBXN4_HUMAN (268-442): 1.92e-23: 104: 17.05		DERL2_HUMAN (1-239): 7.9e-93: 274: 100.00
+	Sc
		797816 UBX2_YEAST (9-430): 9.08e-66: 222: 16.38		DER1_YEAST (13-212): 3.34e-45: 152: 21.29
+	Hs
		122641 UBXN8_HUMAN (260-443): 9.75e-35: 132: 17.94		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15
+	Sc
		798592 UBX7_YEAST (154-445): 4.28e-48: 172: 10.60		DFM1_YEAST (7-238): 2.3e-53: 177: 23.16
+	Hs
		1365049 UBXN4_HUMAN (268-442): 1.92e-23: 104: 17.05		DERL1_HUMAN (6-238): 1.01e-70: 218: 34.15