HitPredict

Interactor 1: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Interactor 2: SMC3 (Q9UQE7)
Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)
Gene: SMC3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12198550
Identification Methods	biochemical
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 488 Hs			1 1217
+	Hs
		334069 HDAC2_HUMAN (1-488): 0: 707: 100.00		SMC2_HUMAN (1-1217): 2.53e-73: 268: 18.97
+	Hs
		1110122 HDAC1_HUMAN (1-443): 0: 642: 90.07		SMC4_HUMAN (1-1206): 2.28e-77: 281: 16.77
+	Hs
		1417730 HDAC8_HUMAN (33-372): 1.02e-137: 403: 43.40		SMC3_HUMAN (1-1217): 1.79e-122: 410: 100.00
+	Hs
		1110225 HDAC1_HUMAN (1-443): 0: 642: 90.07		MYH4_HUMAN (354-1101): 2.04e-24: 113: 9.34
+	Hs
		563054 HDAC1_HUMAN (1-443): 0: 642: 90.07		MYH8_HUMAN (143-798): 1.72e-24: 113: 10.33
+	Hs
		1110177 HDAC1_HUMAN (1-443): 0: 642: 90.07		MYH2_HUMAN (549-1104): 4.41e-16: 86.3: 11.07
+	Hs
		556922 HDAC1_HUMAN (1-443): 0: 642: 90.07		MYH7_HUMAN (627-1126): 2.95e-15: 83.6: 13.49
+	Hs
		556850 HDAC1_HUMAN (1-443): 0: 642: 90.07		MYH1_HUMAN (660-1109): 2.27e-13: 77.4: 10.20
+	Hs
		1130176 HDAC8_HUMAN (33-372): 1.02e-137: 403: 43.40		SMC1A_HUMAN (2-1211): 1.12e-80: 291: 16.52
+	Sc
		864387 HOS1_YEAST (81-317): 4.84e-47: 171: 36.93		SMC3_YEAST (1-1217): 1.81e-84: 302: 29.72