Protein: HDAC8
Histone deacetylase 8 (HD8) (EC 3.5.1.98) (Protein deacetylase HDAC8) (EC 3.5.1.-) (Protein decrotonylase HDAC8) (EC 3.5.1.-)

Gene: HDAC8
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9BY41

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000228 - nuclear chromosome
GO:0004407 - histone deacetylase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

998767

H31
Histone H3.1

1

18

Small-scale

0.647

High

1162030

H31T
Histone H3.1t

1

18

Small-scale

0.618

High

980270

H4
Histone H4

2

13

Small-scale

0.595

High

543594

ERR1
Steroid hormone receptor ERR1

1

20

Small-scale

0.536

High

271293

CPNE3
Copine-3

1

3

High-throughput

0.536

High

336480

SVIL
Supervillin

1

3

High-throughput

0.536

High

916035

NUP98
Nuclear pore complex protein Nup98-Nup96

1

4

High-throughput

0.536

High

1130176

SMC1A
Structural maintenance of chromosomes protein 1A

1

10

High-throughput

0.536

High

1325386

STAG2
Cohesin subunit SA-2

1

2

High-throughput

0.536

High

1417725

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.536

High

1417730

SMC3
Structural maintenance of chromosomes protein 3

1

10

High-throughput

0.536

High

470337

NEP
Neprilysin

1

0

High-throughput

0.513

High

1281686

ZSCA2
Zinc finger and SCAN domain-containing protein 2

1

0

High-throughput

0.513

High

1349295

MDM1
Nuclear protein MDM1

1

0

High-throughput

0.513

High

414552

P53
Cellular tumor antigen p53

1

7

Small-scale

0.501

High

605801

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

Small-scale

0.501

High

175190

SC16A
Protein transport protein Sec16A

1

6

High-throughput

0.489

High

447851

TPM3
Tropomyosin alpha-3 chain

1

7

High-throughput

0.489

High

995470

TPM4
Tropomyosin alpha-4 chain

1

6

High-throughput

0.489

High

1216688

CROCC
Rootletin

1

20

High-throughput

0.489

High

1417726

ADDG
Gamma-adducin

1

1

High-throughput

0.489

High

270270

MTG16
Protein CBFA2T3

1

9

Small-scale

0.479

High

320769

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.479

High

461894

HS90A
Heat shock protein HSP 90-alpha

1

11

Small-scale

0.479

High

593202

CREB1
Cyclic AMP-responsive element-binding protein 1

1

5

Small-scale

0.479

High

761856

HSP74
Heat shock 70 kDa protein 4

1

16

Small-scale

0.479

High

786821

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

8

Small-scale

0.479

High

827914

STAT3
Signal transducer and activator of transcription 3

1

12

Small-scale

0.479

High

957504

UBC12
NEDD8-conjugating enzyme Ubc12

1

7

High-throughput

0.479

High

1046414

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.479

High

1055269

MTG8
Protein CBFA2T1

1

12

Small-scale

0.479

High

1157906

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.479

High

1288976

EST1A
Telomerase-binding protein EST1A

1

2

Small-scale

0.479

High

1417727

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1417728

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1417729

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

2

Small-scale

0.479

High

1417731

DCAF1
DDB1- and CUL4-associated factor 1

1

9

Small-scale

0.479

High

996528

ACTS
Actin, alpha skeletal muscle

1

7

Small-scale

0.437

High

1396796

SNX27
Sorting nexin-27

1

7

High-throughput

0.437

High

1129730

MDC1
Mediator of DNA damage checkpoint protein 1

1

8

Small-scale

0.408

High

1163609

RTN1
Reticulon-1

1

0

Small-scale

0.261

Low


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Last updated: 11Aug2025