Protein: PYRG1
CTP synthase 1 (EC 6.3.4.2) (CTP synthetase 1) (UTP--ammonia ligase 1)

Gene: PYRG1, CTPS1
Organism: Homo sapiens
Interactions: 144
UniProt ID: P17812

Gene Ontology (top 5):
GO:0003883 - CTP synthase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571065

PYRG2
CTP synthase 2

6

9

High-throughput

0.946

High

570964

PYRG1
CTP synthase 1

3

9

High-throughput

0.861

High

345866

MYC
Myc proto-oncogene protein

4

1

High-throughput

0.686

High

528497

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.662

High

571006

CUL3
Cullin-3

2

5

High-throughput

0.611

High

571039

CSN5
COP9 signalosome complex subunit 5

2

3

High-throughput

0.611

High

571019

TIGD3
Tigger transposable element-derived protein 3

2

1

High-throughput

0.574

High

570982

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

3

High-throughput

0.571

High

570991

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

2

4

Small-scale

0.571

High

571053

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

2

4

Small-scale

0.571

High

226461

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

571062

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

2

0

High-throughput

0.559

High

272485

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

571017

FTM
Protein fantom

2

0

High-throughput

0.547

High

571044

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

234900

SNX3
Sorting nexin-3

1

1

High-throughput

0.536

High

545753

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

3

High-throughput

0.536

High

570987

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

571004

CUL1
Cullin-1

1

5

High-throughput

0.536

High

571005

CUL2
Cullin-2

1

5

High-throughput

0.536

High

571007

CUL4B
Cullin-4B

1

5

High-throughput

0.536

High

571026

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

571034

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

571040

CUL5
Cullin-5

1

5

High-throughput

0.536

High

571027

LCA5
Lebercilin

2

1

High-throughput

0.521

High

156598

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

0

High-throughput

0.513

High

542993

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

570974

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

570977

VATE1
V-type proton ATPase subunit E 1

1

0

High-throughput

0.513

High

570990

CF298
Cilia- and flagella-associated protein 298

1

0

High-throughput

0.513

High

571012

NEDD8
NEDD8

1

0

High-throughput

0.513

High

571033

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.513

High

571047

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

571052

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.513

High

570968

1433T
14-3-3 protein theta

1

5

High-throughput

0.501

High

570980

CCNF
Cyclin-F

1

0

High-throughput

0.493

High

571074

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.493

High

571028

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.489

High

133873

DDX3X
ATP-dependent RNA helicase DDX3X

1

2

Small-scale

0.479

High

232779

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

294339

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

354282

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

384223

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

488120

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.479

High

503396

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

569144

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

570966

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

570971

PML
Protein PML

1

3

High-throughput

0.479

High

570972

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.479

High

570986

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

570992

1433G
14-3-3 protein gamma

1

5

High-throughput

0.479

High

570993

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

570994

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.479

High

570997

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

571008

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

571010

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

571011

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

High-throughput

0.479

High

571022

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

571035

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

571037

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

571049

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

571054

WWTR1
WW domain-containing transcription regulator protein 1

1

1

High-throughput

0.479

High

571057

TXNIP
Thioredoxin-interacting protein

1

1

Small-scale

0.479

High

571059

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

571061

BRD7
Bromodomain-containing protein 7

1

1

High-throughput

0.479

High

160368

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

224296

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

242974

EDF1
Endothelial differentiation-related factor 1

1

0

High-throughput

0.458

High

275535

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.458

High

298130

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

304022

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

322156

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

326422

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

329142

F107A
Actin-associated protein FAM107A

1

0

High-throughput

0.458

High

570965

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

570967

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

570973

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

570975

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

570978

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

570979

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

570981

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

570985

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

570988

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

0

High-throughput

0.458

High

570989

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

570995

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

570996

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

570998

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

570999

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

571000

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

571002

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

571003

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

571014

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.458

High

571016

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

571018

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

571020

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

571023

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

571025

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

571030

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.458

High

571032

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

571041

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

571043

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.458

High

571045

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

571051

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

571060

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

571063

ANLN
Anillin

1

0

High-throughput

0.458

High

571064

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

571066

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

571067

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

571068

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

571070

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

571073

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

305953

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

570970

GRN
Progranulin

1

1

High-throughput

0.445

High

571056

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

571058

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

4

High-throughput

0.445

High

378996

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

551898

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

570969

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

570976

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

570983

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.437

High

571001

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.437

High

571013

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

571024

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

571036

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

571038

DPF3
Zinc finger protein DPF3

1

1

Small-scale

0.437

High

571046

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

571055

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

571071

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

373644

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

571015

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

571031

RN169
E3 ubiquitin-protein ligase RNF169

1

0

Small-scale

0.426

High

571075

CSAG2
Chondrosarcoma-associated gene 2/3 protein

1

0

High-throughput

0.426

High

570984

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

571050

RM20
Large ribosomal subunit protein bL20m

1

0

High-throughput

0.279

Low

571048

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.269

Low

282305

NEBL
Nebulette

1

0

High-throughput

0.249

Low

571009

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

571029

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

571042

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.249

Low

571069

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

Small-scale

0.249

Low

571072

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

320972

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.232

Low

571021

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024