Protein: SDS3
Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)

Gene: SDS3, SUDS3
Organism: Homo sapiens
Interactions: 122
UniProt ID: Q9H7L9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0006338 - chromatin remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1110085

HDAC1
Histone deacetylase 1

9

10

Small-scale

0.975

High

1403022

SIN3A
Paired amphipathic helix protein Sin3a

8

9

Small-scale

0.970

High

1368126

HDAC2
Histone deacetylase 2

6

10

Small-scale

0.940

High

274382

SIN3B
Paired amphipathic helix protein Sin3b

5

9

Small-scale

0.933

High

282310

SAP30
Histone deacetylase complex subunit SAP30

3

3

High-throughput

0.861

High

1430811

ING2
Inhibitor of growth protein 2

3

13

Small-scale

0.861

High

1435857

BRMS1
Breast cancer metastasis-suppressor 1

2

6

Small-scale

0.817

High

1208645

BRM1L
Breast cancer metastasis-suppressor 1-like protein

2

6

High-throughput

0.754

High

1435868

ING1
Inhibitor of growth protein 1

1

15

High-throughput

0.691

High

1435856

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

6

Small-scale

0.680

High

1066493

RBBP4
Histone-binding protein RBBP4

3

5

High-throughput

0.675

High

1050752

MAD1
Max dimerization protein 1

3

9

High-throughput

0.667

High

1159007

RBBP7
Histone-binding protein RBBP7

3

5

High-throughput

0.667

High

1308323

LACC1
Purine nucleoside phosphorylase LACC1

3

1

High-throughput

0.667

High

1435858

SHCAF
SIN3-HDAC complex-associated factor

3

2

Small-scale

0.667

High

998030

CSK21
Casein kinase II subunit alpha

2

4

High-throughput

0.634

High

1252857

ZN704
Zinc finger protein 704

2

2

High-throughput

0.628

High

1414386

PHF23
PHD finger protein 23

2

1

High-throughput

0.628

High

1195601

ARI4B
AT-rich interactive domain-containing protein 4B

2

4

Small-scale

0.584

High

1357153

GATD1
GATA zinc finger domain-containing protein 1

2

2

High-throughput

0.584

High

1429905

SP130
Histone deacetylase complex subunit SAP130

2

7

Small-scale

0.584

High

343809

LDOC1
Protein LDOC1

2

0

High-throughput

0.580

High

1390717

DYL2
Dynein light chain 2, cytoplasmic

2

0

High-throughput

0.576

High

1415801

MAD3
Max dimerization protein 3

2

9

High-throughput

0.574

High

242942

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

1402586

SRPK1
SRSF protein kinase 1

1

1

High-throughput

0.550

High

1247083

U17L2
Ubiquitin carboxyl-terminal hydrolase 17

1

0

Small-scale

0.537

High

502130

H2AZ
Histone H2A.Z

1

2

High-throughput

0.536

High

625629

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

711792

ARI4A
AT-rich interactive domain-containing protein 4A

1

4

High-throughput

0.536

High

959656

MAX
Protein max

1

7

High-throughput

0.536

High

1017493

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.536

High

1029760

FOXK2
Forkhead box protein K2

1

8

High-throughput

0.536

High

1123118

FHL2
Four and a half LIM domains protein 2

1

2

High-throughput

0.536

High

1307260

TF2LX
Homeobox protein TGIF2LX

1

8

High-throughput

0.536

High

1428247

TGIF2
Homeobox protein TGIF2

1

7

High-throughput

0.536

High

1435863

LHX3
LIM/homeobox protein Lhx3

1

1

High-throughput

0.536

High

1435865

DAXX
Death domain-associated protein 6

1

1

High-throughput

0.536

High

634639

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

905488

HCFC1
Host cell factor 1

1

0

Small-scale

0.513

High

1023888

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1403315

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

0

High-throughput

0.513

High

936213

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.493

High

1435864

DKK2
Dickkopf-related protein 2

1

2

High-throughput

0.489

High

951856

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

1209665

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

143260

NFIB
Nuclear factor 1 B-type

1

6

High-throughput

0.479

High

155355

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

1

High-throughput

0.479

High

168327

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.479

High

194351

R113A
E3 ubiquitin-protein ligase RNF113A

1

1

High-throughput

0.479

High

210349

PHF1
PHD finger protein 1

1

3

High-throughput

0.479

High

225112

TLX3
T-cell leukemia homeobox protein 3

1

4

High-throughput

0.479

High

243737

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

9

High-throughput

0.479

High

248350

HBP1
HMG box-containing protein 1

1

10

High-throughput

0.479

High

260462

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

285477

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

316994

MTA2
Metastasis-associated protein MTA2

1

6

High-throughput

0.479

High

339859

KLF8
Krueppel-like factor 8

1

12

High-throughput

0.479

High

352246

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

474295

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

519566

MYBB
Myb-related protein B

1

1

High-throughput

0.479

High

520378

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

548609

MPRI
Cation-independent mannose-6-phosphate receptor

1

1

High-throughput

0.479

High

662279

PAX7
Paired box protein Pax-7

1

5

High-throughput

0.479

High

703381

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

9

High-throughput

0.479

High

775913

HNF1B
Hepatocyte nuclear factor 1-beta

1

6

High-throughput

0.479

High

980330

H4
Histone H4

1

2

High-throughput

0.479

High

1049203

RON
Macrophage-stimulating protein receptor

1

1

High-throughput

0.479

High

1067722

EP300
Histone acetyltransferase p300

1

5

High-throughput

0.479

High

1086820

BPTF
Nucleosome-remodeling factor subunit BPTF

1

5

High-throughput

0.479

High

1088021

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.479

High

1088565

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.479

High

1094738

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.479

High

1095103

KLF10
Krueppel-like factor 10

1

9

High-throughput

0.479

High

1102654

MTA1
Metastasis-associated protein MTA1

1

6

High-throughput

0.479

High

1115435

CUL4B
Cullin-4B

1

1

Small-scale

0.479

High

1118684

KLF9
Krueppel-like factor 9

1

12

High-throughput

0.479

High

1132981

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.479

High

1135277

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

11

High-throughput

0.479

High

1137525

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

1152743

ELF2
ETS-related transcription factor Elf-2

1

6

High-throughput

0.479

High

1155777

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

1216630

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1295306

P66A
Transcriptional repressor p66-alpha

1

3

High-throughput

0.479

High

1312692

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

1351163

SP7
Transcription factor Sp7

1

13

High-throughput

0.479

High

1351288

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

9

High-throughput

0.479

High

1357126

ZN296
Zinc finger protein 296

1

4

High-throughput

0.479

High

1361013

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.479

High

1392571

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1396132

Z512B
Zinc finger protein 512B

1

1

High-throughput

0.479

High

1398771

PWP2A
PWWP domain-containing protein 2A

1

2

High-throughput

0.479

High

1401050

PHF12
PHD finger protein 12

1

10

High-throughput

0.479

High

1401395

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1405434

FEV
Protein FEV

1

7

High-throughput

0.479

High

1413343

MTA3
Metastasis-associated protein MTA3

1

6

High-throughput

0.479

High

1416911

KLF16
Krueppel-like factor 16

1

11

High-throughput

0.479

High

1421343

BC11B
B-cell lymphoma/leukemia 11B

1

4

High-throughput

0.479

High

1430822

BC11A
BCL11 transcription factor A

1

4

High-throughput

0.479

High

1434974

SOX17
Transcription factor SOX-17

1

8

High-throughput

0.479

High

1435862

MBD2
Methyl-CpG-binding domain protein 2

1

3

High-throughput

0.479

High

1435869

BRPF3
Bromodomain and PHD finger-containing protein 3

1

1

High-throughput

0.479

High

1435870

MTF2
Metal-response element-binding transcription factor 2

1

3

High-throughput

0.479

High

129438

MEN1
Menin

1

0

High-throughput

0.458

High

693366

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

Small-scale

0.458

High

994799

YBOX1
Y-box-binding protein 1

1

0

High-throughput

0.458

High

995274

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1129751

MDC1
Mediator of DNA damage checkpoint protein 1

1

0

High-throughput

0.458

High

1146478

KS6A2
Ribosomal protein S6 kinase alpha-2

1

0

High-throughput

0.458

High

1157933

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.458

High

1244833

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1276795

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1435859

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1435861

ZN219
Zinc finger protein 219

1

0

High-throughput

0.458

High

1435866

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

318879

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.437

High

1419418

RHBT2
Rho-related BTB domain-containing protein 2

1

3

High-throughput

0.437

High

1435867

HMGX4
HMG domain-containing protein 4

1

8

High-throughput

0.437

High

1063620

GOGA2
Golgin subfamily A member 2

2

0

High-throughput

0.316

High

1348960

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1435860

RM22
Large ribosomal subunit protein uL22m

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025