HitPredict

Interactor 1: KMT2B (O08550)
Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.364) (Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
Gene: KMT2B

Interactor 2: NANOG (Q80Z64)
Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
Gene: NANOG

Species: Mus musculus

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23892456
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2713 Mm			1 305
+	Mm
		1194616 NSD2_MOUSE (809-1411): 1.4e-41: 171: 10.59		NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00
+	Dm
		1181739 TRR_DROME (1580-1788): 4.53e-58: 226: 30.30		Q7KS72_DROME (18-207): 8.44e-27: 109: 24.24
+	Dm
		1359818 Q9W1H0_DROME (949-1404): 2.23e-47: 190: 16.74		Q9V490_DROME (57-297): 1.43e-31: 125: 14.98
+	Mm
		788275 NSD2_MOUSE (809-1411): 1.4e-41: 171: 10.59		NKX25_MOUSE (13-216): 2.84e-33: 126: 22.41
+	Mm
		1142282 EZH2_MOUSE (2567-2695): 1.15e-16: 89: 39.54		NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00
+	Mm
		101829 F8WI37_MOUSE (1611-1691): 2.74e-12: 75.4: 30.49		NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00
+	Mm
		1194614 KMT2C_MOUSE (1611-1691): 2.74e-12: 75.4: 30.49		NANOG_MOUSE (1-305): 9.78e-60: 194: 100.00
+	Hs
		152588 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		PAX7_HUMAN (79-299): 1.61e-33: 130: 16.81
+	Hs
		152596 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80
+	Hs
		620175 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		PAX7_HUMAN (79-299): 1.61e-33: 130: 16.81
+	Hs
		679137 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		TLX1_HUMAN (29-215): 3.58e-34: 128: 22.80
+	Hs
		152615 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		LHX2_HUMAN (8-232): 1.48e-30: 120: 15.49
+	Hs
		152592 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69
+	Hs
		152612 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		LHX1_HUMAN (44-298): 6.25e-30: 118: 13.64
+	Hs
		641482 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		PAX6_HUMAN (37-288): 5.3e-30: 119: 15.69
+	Hs
		822650 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		LHX1_HUMAN (44-298): 6.25e-30: 118: 13.64
+	Hs
		152561 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		TLX2_HUMAN (60-158): 3.78e-27: 108: 30.39
+	Hs
		213358 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		TLX2_HUMAN (60-158): 3.78e-27: 108: 30.39
+	Hs
		152560 KMT2D_HUMAN (1601-1700): 1.2e-09: 66.6: 29.70		TLX3_HUMAN (89-153): 9.32e-09: 57.4: 43.08
+	Hs
		211919 KMT2C_HUMAN (1611-1691): 7.25e-09: 64.1: 31.71		TLX3_HUMAN (89-153): 9.32e-09: 57.4: 43.08