HitPredict

Interactor 1: HDAC1 (O09106)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: RERE (Q80TZ9)
Arginine-glutamic acid dipeptide repeats protein (Atrophin-2)
Gene: RERE

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14645126
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	ELM2~Hist_deacetyl
Common GO terms	GO:0000118 - histone deacetylase complex GO:0003682 - chromatin binding GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Mm			1 1558
+	Hs
		1038770 HDAC1_HUMAN (1-482): 0: 666: 99.38		RERE_HUMAN (29-1558): 0: 629: 93.95
+	Hs
		1270490 HDAC2_HUMAN (1-478): 0: 664: 86.13		RERE_HUMAN (29-1558): 0: 629: 93.95
+	Hs
		91458 HDAC1_HUMAN (1-482): 0: 666: 99.38		E7EQY4_HUMAN (104-630): 7.07e-160: 496: 23.69
+	Hs
		1038676 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA3_HUMAN (104-689): 1.01e-151: 477: 21.90
+	Mm
		140302 HDAC1_MOUSE (1-482): 0: 670: 100.00		MTA1_MOUSE (104-694): 2.3e-148: 473: 21.71
+	Hs
		1031849 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA1_HUMAN (104-694): 2.64e-149: 475: 21.16
+	Hs
		1270415 HDAC2_HUMAN (1-478): 0: 664: 86.13		MTA3_HUMAN (104-689): 1.01e-151: 477: 21.90
+	Hs
		1031919 HDAC2_HUMAN (1-478): 0: 664: 86.13		MTA1_HUMAN (104-694): 2.64e-149: 475: 21.16
+	Mm
		936419 HDAC2_MOUSE (1-478): 0: 663: 85.92		MTA1_MOUSE (104-694): 2.3e-148: 473: 21.71
+	Mm
		140317 HDAC1_MOUSE (1-482): 0: 670: 100.00		MTA2_MOUSE (104-794): 2.82e-126: 411: 20.45
+	Hs
		296017 HDAC1_HUMAN (1-482): 0: 666: 99.38		MTA2_HUMAN (104-794): 5.58e-125: 408: 20.59
+	Mm
		936428 HDAC2_MOUSE (1-478): 0: 663: 85.92		MTA2_MOUSE (104-794): 2.82e-126: 411: 20.45
+	Hs
		296092 HDAC2_HUMAN (1-478): 0: 664: 86.13		MTA2_HUMAN (104-794): 5.58e-125: 408: 20.59
+	Hs
		1038801 HDAC1_HUMAN (1-482): 0: 666: 99.38		RCOR1_HUMAN (284-534): 6.85e-48: 181: 19.61
+	Mm
		140301 HDAC1_MOUSE (1-482): 0: 670: 100.00		RCOR1_MOUSE (284-534): 3.49e-46: 176: 19.61
+	Hs
		1270515 HDAC2_HUMAN (1-478): 0: 664: 86.13		RCOR1_HUMAN (284-534): 6.85e-48: 181: 19.61
+	Mm
		936418 HDAC2_MOUSE (1-478): 0: 663: 85.92		RCOR1_MOUSE (284-534): 3.49e-46: 176: 19.61
+	Hs
		1038768 HDAC1_HUMAN (1-482): 0: 666: 99.38		RCOR3_HUMAN (286-799): 6.67e-40: 158: 14.10
+	Hs
		1270488 HDAC2_HUMAN (1-478): 0: 664: 86.13		RCOR3_HUMAN (286-799): 6.67e-40: 158: 14.10
+	Hs
		203227 HDAC1_HUMAN (1-482): 0: 666: 99.38		SYNJ1_HUMAN (1146-1544): 1.31e-14: 81.8: 9.22