HitPredict

Interactor 1: ACKR2 (O00590)
Atypical chemokine receptor 2 (C-C chemokine receptor D6) (Chemokine receptor CCR-10) (Chemokine receptor CCR-9) (Chemokine-binding protein 2) (Chemokine-binding protein D6)
Gene: ACKR2

Interactor 2: CCL4 (P13236)
C-C motif chemokine 4 (G-26 T-lymphocyte-secreted protein) (HC21) (Lymphocyte activation gene 1 protein) (LAG-1) (MIP-1-beta(1-69)) (Macrophage inflammatory protein 1-beta) (MIP-1-beta) (PAT 744) (Protein H400) (SIS-gamma) (Small-inducible cytokine A4) (T-cell activation protein 2) (ACT-2) [Cleaved into: MIP-1-beta(3-69)]
Gene: CCL4

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	9405404
Identification Methods	competition binding
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006954 - inflammatory response GO:0006955 - immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 384 Hs			1 92
+	Hs
		561029 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL4_HUMAN (1-92): 8.25e-38: 123: 100.00
+	Hs
		598256 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CL3L1_HUMAN (1-92): 5.98e-38: 123: 58.70
+	Hs
		906964 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL13_HUMAN (1-91): 7.32e-37: 121: 39.56
+	Hs
		906961 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL14_HUMAN (1-92): 2.02e-35: 117: 43.01
+	Hs
		518820 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL3_HUMAN (1-92): 6.07e-35: 116: 57.61
+	Hs
		906959 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL7_HUMAN (17-90): 1.31e-29: 103: 37.33
+	Hs
		562840 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL2_HUMAN (1-90): 1.12e-28: 100: 36.26
+	Hs
		906958 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL18_HUMAN (1-92): 1.1e-28: 100: 43.48
+	Hs
		562882 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL5_HUMAN (1-92): 1.15e-27: 97.7: 45.65
+	Hs
		906962 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL15_HUMAN (1-90): 3.06e-27: 97.3: 37.62
+	Hs
		906842 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL11_HUMAN (1-91): 5.59e-27: 96.2: 40.22
+	Hs
		907075 CCR8_HUMAN (13-361): 2.73e-97: 295: 33.24		CCL18_HUMAN (1-92): 1.1e-28: 100: 43.48
+	Hs
		124865 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL24_HUMAN (1-90): 1.21e-24: 90.8: 29.67
+	Hs
		906965 CCR3_HUMAN (20-360): 2.6e-99: 300: 36.71		CCL26_HUMAN (23-90): 2.63e-24: 89.2: 47.06
+	Hs
		518813 CXCR5_HUMAN (25-354): 1.96e-88: 273: 31.11		CCL3_HUMAN (1-92): 6.07e-35: 116: 57.61
+	Hs
		648028 CCR8_HUMAN (13-361): 2.73e-97: 295: 33.24		CCL1_HUMAN (1-89): 1.42e-25: 92.7: 32.58
+	Hs
		907077 CCR8_HUMAN (13-361): 2.73e-97: 295: 33.24		CCL17_HUMAN (7-90): 3.89e-24: 88.8: 29.76
+	Hs
		191478 CCR8_HUMAN (13-361): 2.73e-97: 295: 33.24		CCL16_HUMAN (1-91): 1.41e-23: 88.1: 39.36
+	Hs
		191475 CXCR5_HUMAN (25-354): 1.96e-88: 273: 31.11		CCL16_HUMAN (1-91): 1.41e-23: 88.1: 39.36
+	Hs
		855285 XCR1_HUMAN (11-342): 2.15e-90: 277: 34.94		XCL1_HUMAN (1-91): 1.31e-20: 80.4: 28.57