HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	25604459
Identification Methods	tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 530
+	Hs
		368984 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		261304 FLNB_HUMAN (28-2647): 0: 2710: 69.63		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		261174 FLNB_HUMAN (28-2647): 0: 2710: 69.63		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487127 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		1052915 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		521591 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		993279 ACTN3_HUMAN (30-460): 2.85e-118: 401: 25.28		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		211633 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369420 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368893 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		211456 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		521532 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		211472 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		957553 PGBM_HUMAN (181-1251): 3.53e-32: 140: 12.81		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Mm
		580490 ACTN2_MOUSE (6-459): 1.76e-121: 410: 23.62		ANDR_MOUSE (149-407): 1.53e-38: 152: 33.70
+	Hs
		211471 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59