HitPredict

Interactor 1: RING2 (Q9CQJ4)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING-type E3 ubiquitin transferase RING2)
Gene: Rnf2

Interactor 2: CBX6 (Q9DBY5)
Chromobox protein homolog 6
Gene: CBX6

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17296600
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	CBX7_C~RAWUL
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0016604 - nuclear body and 1 others more... GO:0031519 - PcG protein complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 336 Mm			1 414
+	Mm
		1247833 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		Q6TKP2_MOUSE (1-395): 8.36e-133: 398: 96.20
+	Hs
		338939 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX6_HUMAN (1-395): 5.26e-102: 310: 87.60
+	Mm
		1423710 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		CBX8_MOUSE (1-395): 7.47e-82: 257: 35.50
+	Hs
		1404773 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX8_HUMAN (1-395): 3.6e-79: 251: 33.91
+	Mm
		721344 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		CBX2_MOUSE (2-396): 1.28e-64: 217: 22.01
+	Hs
		338825 RING1_HUMAN (10-336): 3.77e-66: 215: 51.75		CBX6_HUMAN (1-395): 5.26e-102: 310: 87.60
+	Mm
		237306 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		CBX4_MOUSE (1-365): 1.49e-58: 201: 24.10
+	Dr
		1281810 RING2_DANRE (1-336): 1.12e-103: 309: 89.29		Q804D1_DANRE (1-387): 6.05e-61: 206: 24.74
+	Hs
		1132226 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX2_HUMAN (2-396): 1.15e-56: 196: 20.34
+	Hs
		129792 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX4_HUMAN (1-364): 3.13e-56: 196: 23.08
+	Mm
		205501 RING1_MOUSE (10-336): 9.03e-69: 222: 52.00		CBX8_MOUSE (1-395): 7.47e-82: 257: 35.50
+	Hs
		351400 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX7_HUMAN (1-173): 2.38e-36: 135: 41.04
+	Mm
		205487 RING1_MOUSE (10-336): 9.03e-69: 222: 52.00		CBX2_MOUSE (2-396): 1.28e-64: 217: 22.01
+	Mm
		1354000 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		CBX7_MOUSE (1-88): 6.25e-32: 120: 62.50
+	Hs
		1097516 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX3_HUMAN (9-72): 1.97e-23: 98.2: 37.50
+	Mm
		1423705 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		Q9DCC5_MOUSE (9-72): 1.97e-23: 98.2: 37.50
+	Mm
		654695 RING2_MOUSE (1-336): 1.6e-106: 316: 100.00		CBX3_MOUSE (9-72): 2.29e-23: 98.2: 35.94
+	Hs
		129723 RING1_HUMAN (10-336): 3.77e-66: 215: 51.75		CBX4_HUMAN (1-364): 3.13e-56: 196: 23.08
+	Hs
		1014184 RING2_HUMAN (1-336): 2.07e-106: 316: 99.70		CBX1_HUMAN (17-76): 6.67e-21: 91.5: 40.00
+	Mm
		205496 RING1_MOUSE (10-336): 9.03e-69: 222: 52.00		CBX7_MOUSE (1-88): 6.25e-32: 120: 62.50