HitPredict

Interactor 1: PKHA5 (Q9HAU0)
Pleckstrin homology domain-containing family A member 5 (PH domain-containing family A member 5) (Phosphoinositol 3-phosphate-binding protein 2) (PEPP-2)
Gene: PLEKHA5

Interactor 2: PKHA6 (Q9Y2H5)
Pleckstrin homology domain-containing family A member 6 (PH domain-containing family A member 6) (Phosphoinositol 3-phosphate-binding protein 3) (PEPP-3)
Gene: PLEKHA6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.80	0.625

Property	Details
Experiments	20936779
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~PH
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1116 Hs			1 1048
+	Hs
		1437663 PKHA5_HUMAN (1-1116): 0: 685: 100.00		PKHA5_HUMAN (1-1012): 6.39e-102: 347: 28.45
+	Hs
		1030696 PKHA5_HUMAN (1-1116): 0: 685: 100.00		ANK2_HUMAN (153-1043): 5.19e-51: 199: 11.56
+	Hs
		1433931 PKHA5_HUMAN (1-1116): 0: 685: 100.00		PKHA4_HUMAN (33-370): 2.09e-24: 112: 25.14
+	Hs
		1234823 PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40		PKHA7_HUMAN (1-952): 8.21e-87: 305: 24.40
+	Hs
		1234831 PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Hs
		1234956 PKHA7_HUMAN (2-1059): 1.41e-137: 446: 27.40		PKHA4_HUMAN (33-370): 2.09e-24: 112: 25.14
+	Hs
		1324038 RHG24_HUMAN (165-755): 1.4e-65: 238: 13.56		DOC10_HUMAN (60-641): 1.12e-60: 229: 12.58
+	Hs
		1434270 PKHA6_HUMAN (109-1116): 9.07e-88: 308: 28.41		PKHA4_HUMAN (33-370): 2.09e-24: 112: 25.14
+	Hs
		1324008 RHG24_HUMAN (165-755): 1.4e-65: 238: 13.56		RHG24_HUMAN (60-650): 1.04e-42: 169: 13.42
+	Hs
		643375 RHG24_HUMAN (165-755): 1.4e-65: 238: 13.56		OSBP1_HUMAN (62-484): 8.58e-37: 151: 15.09
+	Ce
		90589 C1P633_CAEEL (8-652): 1.85e-62: 233: 12.33		G5EE23_CAEEL (55-755): 1.4e-37: 155: 10.50
+	Ce
		90608 C1P635_CAEEL (8-652): 1.18e-59: 224: 12.56		G5EE23_CAEEL (55-755): 1.4e-37: 155: 10.50
+	Hs
		1140287 ACAP2_HUMAN (73-689): 4.4e-59: 220: 13.91		ACAP3_HUMAN (35-313): 6.74e-38: 155: 15.63
+	Hs
		1030662 ANK2_HUMAN (261-1106): 2.88e-56: 216: 10.80		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Dm
		119660 M9PB30_DROME (261-1108): 1.32e-81: 296: 12.01		M9PB30_DROME (655-1047): 4.09e-09: 63.2: 10.30
+	Hs
		1250722 MPRIP_HUMAN (79-765): 7.82e-54: 206: 12.95		MPRIP_HUMAN (2-252): 1.01e-36: 152: 22.53
+	Dm
		1268535 Q7KNQ9_DROME (45-401): 9.43e-52: 201: 16.37		Q9V9Q6_DROME (62-156): 1.89e-15: 82: 27.83