HitPredict

Interactor 1: CYLD (Q9NQC7)
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)
Gene: CYLD

Interactor 2: RN114 (Q9Y508)
E3 ubiquitin-protein ligase RNF114 (EC 2.3.2.27) (RING finger protein 114) (RING-type E3 ubiquitin transferase RNF114) (Zinc finger protein 228) (Zinc finger protein 313)
Gene: RNF114

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29291351
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0008270 - zinc ion binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 956 Hs			1 228
+	Hs
		1382345 CYLD_HUMAN (1-956): 0: 1872: 100.00		RN166_HUMAN (2-227): 3.3e-58: 185: 40.69
+	Hs
		1447040 CYLD_HUMAN (1-956): 0: 1872: 100.00		TRAF6_HUMAN (19-179): 7.75e-28: 111: 20.48
+	Hs
		623558 CYLD_HUMAN (1-956): 0: 1872: 100.00		RO52_HUMAN (14-139): 1.06e-27: 111: 19.29
+	Hs
		1446981 CYLD_HUMAN (1-956): 0: 1872: 100.00		KCMF1_HUMAN (49-220): 5.74e-27: 108: 22.29
+	Hs
		1246164 CYLD_HUMAN (1-956): 0: 1872: 100.00		TRAF7_HUMAN (20-174): 5.34e-24: 101: 18.71
+	Hs
		1434408 CYLD_HUMAN (1-956): 0: 1872: 100.00		RNF41_HUMAN (20-120): 6.52e-14: 71.3: 26.61
+	Mm
		999852 CYLD_MOUSE (1-956): 0: 1825: 94.46		TRAF6_MOUSE (19-179): 8.23e-29: 114: 19.88