Protein: RN166
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)

Gene: RN166, RNF166
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q96A37

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006914 - autophagy
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1382356

UB2D4
Ubiquitin-conjugating enzyme E2 D4

3

20

High-throughput

0.861

High

1382358

RN114
E3 ubiquitin-protein ligase RNF114

2

20

High-throughput

0.811

High

982272

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

20

Small-scale

0.800

High

906732

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

20

High-throughput

0.791

High

1127749

HLTF
Helicase-like transcription factor

2

7

High-throughput

0.789

High

957639

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

High-throughput

0.783

High

1232900

XAF1
XIAP-associated factor 1

4

7

Small-scale

0.702

High

909365

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

20

High-throughput

0.698

High

957155

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

970887

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

20

High-throughput

0.698

High

1218739

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

20

High-throughput

0.698

High

1382330

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.698

High

1382337

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

20

High-throughput

0.698

High

1382342

RNF41
E3 ubiquitin-protein ligase NRDP1

1

19

High-throughput

0.698

High

1382343

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

1

20

High-throughput

0.698

High

1382344

TRI39
E3 ubiquitin-protein ligase TRIM39

1

18

High-throughput

0.698

High

507303

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

20

High-throughput

0.691

High

299782

MPDZ
Multiple PDZ domain protein

3

20

High-throughput

0.667

High

332427

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

3

High-throughput

0.667

High

767295

MERL
Merlin

3

8

High-throughput

0.667

High

1058906

ZO1
Tight junction protein 1

3

13

High-throughput

0.667

High

1085098

KIF1A
Kinesin-like protein KIF1A

3

9

High-throughput

0.667

High

1341082

INADL
InaD-like protein

3

20

High-throughput

0.667

High

1382340

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

3

3

High-throughput

0.667

High

242520

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.665

High

1382338

PAR12
Protein mono-ADP-ribosyltransferase PARP12

3

14

High-throughput

0.662

High

508394

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

20

High-throughput

0.647

High

1382329

RN166
E3 ubiquitin-protein ligase RNF166

1

19

Small-scale

0.647

High

639282

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

18

High-throughput

0.628

High

1382353

CLC4E
C-type lectin domain family 4 member E

2

3

High-throughput

0.628

High

1381176

UB2E3
Ubiquitin-conjugating enzyme E2 E3

1

20

High-throughput

0.625

High

1382333

UB2E2
Ubiquitin-conjugating enzyme E2 E2

1

20

High-throughput

0.625

High

1216186

DDI2
Protein DDI1 homolog 2

1

17

High-throughput

0.618

High

1382357

TRAF6
TNF receptor-associated factor 6

1

19

Small-scale

0.618

High

342999

HERC2
E3 ubiquitin-protein ligase HERC2

2

18

High-throughput

0.611

High

487616

PARP1
Poly [ADP-ribose] polymerase 1

2

18

High-throughput

0.611

High

883928

CENPF
Centromere protein F

2

20

High-throughput

0.611

High

1197046

AMOT
Angiomotin

2

18

High-throughput

0.611

High

1217032

HECD2
Probable E3 ubiquitin-protein ligase HECTD2

2

16

High-throughput

0.611

High

787572

TNR3
Tumor necrosis factor receptor superfamily member 3

3

20

High-throughput

0.609

High

1292499

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

3

3

High-throughput

0.609

High

1314092

AMOL1
Angiomotin-like protein 1

3

20

High-throughput

0.609

High

1382346

PAR11
Protein mono-ADP-ribosyltransferase PARP11

3

14

High-throughput

0.609

High

1382339

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

0

High-throughput

0.586

High

1382345

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

9

Small-scale

0.578

High

1231179

TRI68
E3 ubiquitin-protein ligase TRIM68

1

18

High-throughput

0.575

High

165813

TR13B
Tumor necrosis factor receptor superfamily member 13B

2

8

High-throughput

0.574

High

1348905

PLPR1
Phospholipid phosphatase-related protein type 1

2

3

High-throughput

0.574

High

1382352

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

1

High-throughput

0.574

High

1108004

SQSTM
Sequestosome-1

1

14

Small-scale

0.561

High

617454

DNLI1
DNA ligase 1

2

3

High-throughput

0.558

High

1276140

NUP54
Nucleoporin p54

2

5

High-throughput

0.558

High

1382336

NUP58
Nucleoporin p58/p45

2

2

High-throughput

0.558

High

848161

MAGA1
Melanoma-associated antigen 1

1

11

Small-scale

0.552

High

1093680

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

3

High-throughput

0.541

High

249643

SNX3
Sorting nexin-3

1

2

High-throughput

0.536

High

858795

BRCC3
Lys-63-specific deubiquitinase BRCC36

1

4

High-throughput

0.536

High

892602

DNLI3
DNA ligase 3

1

1

High-throughput

0.536

High

1192954

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

17

High-throughput

0.536

High

1276601

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

14

High-throughput

0.536

High

1312891

PARP9
Protein mono-ADP-ribosyltransferase PARP9

1

17

High-throughput

0.536

High

1332297

BOLL
Protein boule-like

1

15

High-throughput

0.536

High

1382347

BMP2K
BMP-2-inducible protein kinase

1

9

High-throughput

0.536

High

715939

AQP1
Aquaporin-1

1

1

High-throughput

0.515

High

846411

MATR3
Matrin-3

1

10

High-throughput

0.515

High

1382349

BABA2
BRISC and BRCA1-A complex member 2

1

0

High-throughput

0.513

High

1350834

MAGE2
Melanoma-associated antigen E2

1

11

Small-scale

0.504

High

377115

GLHA
Glycoprotein hormones alpha chain

1

1

High-throughput

0.489

High

536283

PPAL
Lysosomal acid phosphatase

1

1

High-throughput

0.489

High

1022091

TSG6
Tumor necrosis factor-inducible gene 6 protein

1

2

High-throughput

0.489

High

1219814

PLPP4
Phospholipid phosphatase 4

1

3

High-throughput

0.489

High

1324245

ARM10
Armadillo repeat-containing protein 10

1

3

High-throughput

0.489

High

1382334

CC85A
Coiled-coil domain-containing protein 85A

1

2

High-throughput

0.489

High

288484

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

20

High-throughput

0.481

High

239166

ZNRD2
Protein ZNRD2

1

1

High-throughput

0.479

High

1022763

XIAP
E3 ubiquitin-protein ligase XIAP

1

17

Small-scale

0.479

High

1094947

TRAF3
TNF receptor-associated factor 3

1

15

Small-scale

0.479

High

1113932

CUL3
Cullin-3

1

20

High-throughput

0.479

High

1278059

MAVS
Mitochondrial antiviral-signaling protein

1

18

Small-scale

0.479

High

1096148

TADBP
TAR DNA-binding protein 43

1

20

High-throughput

0.470

High

251373

GMDS
GDP-mannose 4,6 dehydratase

1

0

High-throughput

0.458

High

1382332

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.458

High

222170

NCK2
Cytoplasmic protein NCK2

1

17

High-throughput

0.445

High

591427

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

2

High-throughput

0.445

High

1093156

STK4
Serine/threonine-protein kinase 4

1

18

High-throughput

0.445

High

1199182

PAR10
Protein mono-ADP-ribosyltransferase PARP10

1

14

High-throughput

0.445

High

1382341

SAV1
Protein salvador homolog 1

1

17

High-throughput

0.445

High

1382350

ARP3B
Actin-related protein 3B

1

18

High-throughput

0.445

High

1382351

MAGC2
Melanoma-associated antigen C2

1

11

Small-scale

0.439

High

916016

NUP98
Nuclear pore complex protein Nup98-Nup96

1

6

High-throughput

0.437

High

1041459

ACY1
Aminoacylase-1

1

1

High-throughput

0.437

High

1382354

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.437

High

442785

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.426

High

133677

WASL
Actin nucleation-promoting factor WASL

1

1

High-throughput

0.407

High

143750

WN10B
Protein Wnt-10b

1

1

High-throughput

0.407

High

340380

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.407

High

1358012

TM171
Transmembrane protein 171

1

1

High-throughput

0.407

High

1367870

ARC1A
Actin-related protein 2/3 complex subunit 1A

1

4

High-throughput

0.407

High

1382335

S35A5
UDP-sugar transporter protein SLC35A5

1

1

High-throughput

0.407

High

1382355

SL9A8
Sodium/hydrogen exchanger 8

1

1

High-throughput

0.407

High

1382359

LRRF2
Leucine-rich repeat flightless-interacting protein 2

1

12

High-throughput

0.407

High

1382331

CK024
Uncharacterized protein C11orf24

2

0

High-throughput

0.328

High

617719

XRCC1
DNA repair protein XRCC1

2

0

High-throughput

0.318

High

387630

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.279

Low

1181024

DB136
Defensin beta 136

1

0

High-throughput

0.279

Low

1314523

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

1382348

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.279

Low

1086280

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

1339124

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

261243

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

278927

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.232

Low

1337408

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025