Protein: CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD)

Gene: CYLD
Organism: Mus musculus
Interactions: 26
UniProt ID: Q80TQ2

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005813 - centrosome
GO:0005819 - spindle
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

509132

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related 1; Ubiquitin-related 2]

2

4

Small-scale

0.768

High

1225654

SQSTM
Sequestosome-1

4

4

Small-scale

0.687

High

999852

TRAF6
TNF receptor-associated factor 6

3

11

Small-scale

0.657

High

1281917

BCL3
B-cell lymphoma 3 protein homolog

2

3

Small-scale

0.608

High

1281913

ITCH
E3 ubiquitin-protein ligase Itchy

2

2

Small-scale

0.601

High

312504

NEMO
NF-kappa-B essential modulator

2

3

Small-scale

0.584

High

1281914

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

Small-scale

0.561

High

1193799

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.536

High

440282

LCK
Proto-oncogene tyrosine-protein kinase LCK

1

2

Small-scale

0.515

High

313451

CASP8
Caspase-8

1

2

Small-scale

0.501

High

997256

TBA1A
Tubulin alpha-1A chain

1

6

Small-scale

0.500

High

370856

FOS
Protein c-Fos

1

1

Small-scale

0.479

High

946717

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

Small-scale

0.479

High

1188371

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1221519

TRAF3
TNF receptor-associated factor 3

1

8

Small-scale

0.479

High

1221634

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

3

Small-scale

0.479

High

1223473

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

1281911

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.479

High

1281912

TRI47
E3 ubiquitin-protein ligase TRIM47

1

3

Small-scale

0.479

High

1281918

HDAC6
Protein deacetylase HDAC6

1

1

Small-scale

0.479

High

432094

JUN
Transcription factor Jun

1

0

Small-scale

0.458

High

838307

STAT3
Signal transducer and activator of transcription 3

1

0

Small-scale

0.458

High

1190022

NTRK1
High affinity nerve growth factor receptor

1

3

Small-scale

0.437

High

1223591

DLG4
Disks large homolog 4

1

2

High-throughput

0.437

High

1281916

SRCN1
SRC kinase signaling inhibitor 1

1

0

High-throughput

0.426

High

1281915

DLGP1
Disks large-associated protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025