HitPredict

Interactor 1: BIN1 (O08539)
Myc box-dependent-interacting protein 1 (Amphiphysin II) (Amphiphysin-like protein) (Bridging integrator 1) (SH3 domain-containing protein 9)
Gene: BIN1

Interactor 2: DYN2 (P39054)
Dynamin-2 (EC 3.6.5.5) (Dynamin UDNM)
Gene: Dnm2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	37139790, 23640057
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005768 - endosome GO:0005874 - microtubule GO:0048488 - synaptic vesicle endocytosis GO:0098793 - presynapse
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 588 Mm			1 870
+	Hs
		138464 BIN1_HUMAN (1-587): 5.5e-159: 469: 94.44		DYN2_HUMAN (1-870): 0: 1090: 98.16
+	Mm
		147411 BIN1_MOUSE (1-588): 8.65e-171: 499: 100.00		DYN1_MOUSE (1-868): 0: 1042: 77.74
+	Mm
		147426 BIN1_MOUSE (1-588): 8.65e-171: 499: 100.00		DYN3_MOUSE (1-870): 0: 1021: 78.17
+	Rn
		148402 BIN1_RAT (1-588): 4.03e-169: 495: 99.15		DYN1_RAT (1-847): 0: 1021: 78.71
+	Hs
		138481 BIN1_HUMAN (1-587): 5.5e-159: 469: 94.44		DYN1_HUMAN (1-847): 0: 1028: 79.18
+	Mm
		810550 AMPH_MOUSE (9-574): 9.99e-98: 314: 43.12		DYN2_MOUSE (1-870): 0: 1100: 100.00
+	Rn
		148389 AMPH_RAT (9-547): 3.27e-97: 312: 45.04		DYN2_RAT (1-870): 0: 1097: 99.66
+	Hs
		896800 DNMBP_HUMAN (17-584): 3.23e-77: 268: 14.14		DYN2_HUMAN (1-870): 0: 1090: 98.16
+	Mm
		810531 AMPH_MOUSE (9-574): 9.99e-98: 314: 43.12		DYN1_MOUSE (1-868): 0: 1042: 77.74
+	Mm
		1274568 AMPH_MOUSE (9-574): 9.99e-98: 314: 43.12		DYN3_MOUSE (1-870): 0: 1021: 78.17
+	Rn
		148388 AMPH_RAT (9-547): 3.27e-97: 312: 45.04		DYN1_RAT (1-847): 0: 1021: 78.71
+	Hs
		1050693 DNMBP_HUMAN (17-584): 3.23e-77: 268: 14.14		DYN1_HUMAN (1-847): 0: 1028: 79.18
+	Hs
		1251281 DNMBP_HUMAN (17-584): 3.23e-77: 268: 14.14		DYN3_HUMAN (1-870): 0: 1019: 79.32
+	Hs
		883030 AMPH_HUMAN (84-588): 6.68e-22: 102: 18.84		DYN2_HUMAN (1-870): 0: 1090: 98.16
+	Hs
		1050729 CABIN_HUMAN (266-535): 3.28e-25: 113: 13.50		DYN1_HUMAN (1-847): 0: 1028: 79.18
+	Hs
		883038 AMPH_HUMAN (84-588): 6.68e-22: 102: 18.84		DYN1_HUMAN (1-847): 0: 1028: 79.18
+	Hs
		883070 AMPH_HUMAN (84-588): 6.68e-22: 102: 18.84		DYN3_HUMAN (1-870): 0: 1019: 79.32
+	Sc
		639018 RV167_YEAST (16-442): 3.9e-55: 195: 13.59		VPS1_YEAST (7-739): 0: 696: 37.39