HitPredict

Interactor 1: SOCS3 (O14543)
Suppressor of cytokine signaling 3 (SOCS-3) (Cytokine-inducible SH2 protein 3) (CIS-3) (STAT-induced STAT inhibitor 3) (SSI-3)
Gene: SOCS3

Interactor 2: CUL5 (Q93034)
Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
Gene: CUL5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.689

Property	Details
Experiments	24438103, 30166453, 17135358, 15601820
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 225 Hs			1 780
+	Hs
		1263831 SOCS4_HUMAN (16-221): 1.2e-53: 179: 20.29		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		146692 SOCS7_HUMAN (13-221): 5.98e-51: 175: 24.17		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1265273 SOCS4_MOUSE (16-221): 3.49e-53: 178: 20.77		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193394 SOCS3_MOUSE (1-225): 1.12e-54: 176: 96.89		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		1257617 SOCS7_MOUSE (13-221): 4.57e-51: 175: 24.17		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		256856 SOCS5_HUMAN (23-221): 1.49e-47: 165: 21.00		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1322060 SOCS6_MOUSE (34-220): 9.75e-49: 168: 26.32		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		222648 SOCS5_MOUSE (23-221): 4.66e-47: 164: 21.00		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		146642 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		1274062 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Mm
		1143676 CISH_MOUSE (13-221): 1.36e-46: 156: 29.86		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Mm
		193366 SOCS2_MOUSE (3-221): 2.11e-46: 154: 28.31		CUL5_MOUSE (1-780): 0: 786: 98.46
+	Hs
		147544 SOCS6_HUMAN (15-220): 4.58e-39: 143: 22.64		CUL5_HUMAN (1-780): 0: 792: 100.00
+	Hs
		147421 SOCS3_HUMAN (1-225): 5.1e-54: 174: 100.00		CUL4B_HUMAN (16-780): 0: 736: 25.39
+	Hs
		411713 LCK_HUMAN (34-219): 9.16e-44: 155: 15.32		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		1042817 VAV3_HUMAN (24-202): 1.86e-41: 151: 14.53		CUL3_HUMAN (8-780): 0: 754: 22.96
+	Hs
		146625 SOCS2_HUMAN (3-221): 1.16e-46: 154: 28.31		CUL4A_HUMAN (16-780): 0: 744: 24.48
+	Hs
		1041477 CISH_HUMAN (13-221): 1.55e-45: 153: 30.62		CUL2_HUMAN (6-780): 0: 699: 26.36
+	Dm
		186280 O18683_DROME (18-158): 2.65e-38: 140: 17.02		CUL1_DROME (3-780): 0: 694: 25.99
+	Hs
		181856 SOCS1_HUMAN (19-221): 4.01e-37: 130: 25.98		CUL2_HUMAN (6-780): 0: 699: 26.36