HitPredict

Interactor 1: GNB5 (O14775)
Guanine nucleotide-binding protein subunit beta-5 (Gbeta5) (Transducin beta chain 5)
Gene: GNB5

Interactor 2: GBG4 (P50150)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene: GNG4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	8636150
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	G-gamma~WD40
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0007186 - G protein-coupled receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 395 Hs			1 75
+	Hs
		154672 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33
+	Mm
		837708 GNB5_MOUSE (1-395): 6.78e-115: 342: 99.24		GBG4_MOUSE (1-75): 4.88e-30: 102: 98.67
+	Hs
		154670 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47
+	Hs
		154700 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG8_HUMAN (7-75): 3.45e-25: 90.1: 60.87
+	Hs
		154646 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG7_HUMAN (8-75): 1.85e-24: 88.2: 60.29
+	Hs
		154673 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG5_HUMAN (8-75): 8.6e-21: 78.9: 45.59
+	Hs
		154698 GNB5_HUMAN (1-395): 3.65e-115: 342: 100.00		GBG13_HUMAN (13-75): 6.79e-18: 71.6: 34.92
+	Dm
		669788 GBB2_DROME (51-394): 1.66e-106: 319: 35.17		GBGE_DROME (15-75): 4.34e-16: 67: 31.15
+	Hs
		560864 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG4_HUMAN (1-75): 1.41e-30: 103: 100.00
+	Hs
		560872 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG3_HUMAN (1-75): 7.91e-30: 102: 69.33
+	Hs
		560868 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47
+	Hs
		560895 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG8_HUMAN (7-75): 3.45e-25: 90.1: 60.87
+	Hs
		229235 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG7_HUMAN (8-75): 1.85e-24: 88.2: 60.29
+	Hs
		560893 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG12_HUMAN (7-75): 1.55e-23: 85.9: 56.52
+	Hs
		560865 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG10_HUMAN (8-75): 1.32e-21: 80.9: 48.53
+	Hs
		560873 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG5_HUMAN (8-75): 8.6e-21: 78.9: 45.59
+	Hs
		560871 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG1_HUMAN (15-74): 8.79e-19: 73.9: 36.67
+	Hs
		560892 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG13_HUMAN (13-75): 6.79e-18: 71.6: 34.92
+	Hs
		150112 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBGT2_HUMAN (16-74): 1.31e-15: 65.8: 37.29
+	Hs
		560869 GBB3_HUMAN (13-309): 4.32e-60: 199: 16.89		GBG11_HUMAN (14-74): 1.57e-15: 65.8: 36.07